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Cytotoxicity and in vivo Toxicological Screening of a Polyherbal Product,nefang

Cytotoxicity and in vivo Toxicological Screening of a Polyhe...

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第十四届全国中药和天然药物学术研讨会

作者： Protus Arrey Tarkang Gabriel A.Agbor Faith A.Okalebo Anastasia N.Guantai Institute of Medical Research and Medicinal Plants Studies (IMPM) Cameroon University of Nairobi Kenya

nefang is a polyherbal product composed of Mangifera indica（bark and leaf）,Psidium guajava,Carica papaya,Cymbopogon citratus,Citrus sinensis and Ocimum gratissimum（leaves）.It is often used in Cameroon traditional medicine as an *** studies have demonstrated its in vitro antiplasmodial activity,synergistic interactions between its constituents[1],antioxidant properties[2]and in vivo antiplasmodial efficacy（unpublished）.This study aimed at evaluating its cytotoxicity and in vivo *** screening was evaluated on Hep G2 hepatoma and U20 S osteosarcoma epithelial cell lines[3,4].Systemic acute oral toxicity was assessed in Swiss albino mice,while repeated dose（28 and 90 days） toxicity were studied in wistar rats at doses of 250,500 and 1000 mgkg-1 body weight[5].Physiological,biochemical and hematological parameters were analysed to determine its effects on the liver,kidney,lipid profile,nitrogen balance,glycemic levels and the hematological *** analysed using the one way ANOVA followed by Neuman-Keuls multiple comparison *** showed no significant cytotoxic *** and repeated dose oral toxicity produced no observed adverse effects at a dose ＞5 g/kg as well as on the liver,kidney and lipid profiles ***-acute administration of nefang significantly（p＜0.05） lowered the GLU levels more than *** also observed a dose-dependent significant（p＜0.05） increase in white and red blood cells count,hemoglobin,hematocrit and platelet *** findings suggest that nefang is relatively safe when administered orally after short or prolonged periods,at sub-therapeutic and therapeutic *** these doses,it exhibited potentials at maintaining the integral functioning of the liver,kidney and boosting the immune *** also showed good potentials at maintaining a good nitrogen balance and hypoglycemic *** study demonstrated the safety of nefang,thus upholding knowledge on its folk use and suggest

关键词： nefang medicinal plants cytotoxicity in vivo toxicity hepatotoxicity renal toxicity.

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