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Rosai-Dorfman disease with lung involvement in a 10-year-old patient:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4285-4293页

作者： Guo-Jing Wu Bo-Bo Li Ren-Liang Zhu Chao-Jie Yang Wen-Yong Chen The Second Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Otolaryngology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Rosai-Dorfman disease(RDD)is a rare benign proliferative disease whose etiology is not clear and may be related to infection or unexplained immune *** authors present a case of RDD with lung involvement in a 10-year-old *** SUMMARY A 10-year-old girl found that her left cervical lymph nodes were enlarged for more than 7 mo,and the largest range was about 6.5 cm×5.9 cm×8.1 *** magnetic resonance imaging showed multiple masses in the left neck,with low signal intensity on T1-weighted images and high signal intensity on T2-weighted images.A malignant tumor,with a high possibility of lymph node metastasis,was initially *** the same time,lung computed tomography showed multiple nodules of different sizes scattered on both sides of the lung,with uniform internal ***,a possible metastatic tumor was ***,RDD was diagnosed by pathology and *** to the antibiogram,clindamycin was administered for 2 wk,and prednisone acetate was administered for 7 *** months later,the ulcer in the left neck was better than before,but the imaging showed that the lesion was not *** The diagnosis of RDD cannot be made by a single tool and its treatment is a longterm exploratory ***-up is necessary.

关键词： Rosai-Dorfman disease Cervical lymphadenopathy neck mass Lung Case report

Laparoscopic Omohyoid Muscle Transection Surgery： A Novel Procedure Against Omohyoid Muscle Syndrome

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Chinese Medical Journal 2016年第5期129卷 604-605页

作者： Zhi-Peng Sun Yu-Bing Zhu Neng-Wei Zhang Department of General Surgery Beijing Shijitan Hospital Capital Medical University Peking University Ninth School of Clinical Medicine. Beiiino 100038. China Department of Ontology Surgery Beijing Shijitan Hospital Capital Medical University Peking University Ninth School of Clinical Medicine Beijing 100038 China

Omohyoid muscle syndrome （OMS）, also called omohyoid sling syndrome, is a rare disease. The first OMS case was reported in 1980. OMS is presented by a mass without pain on the neck when the patient swallows and disa... 详细信息

关键词： Laparoscopic Surgery Omohyoid Muscle Syndrome neck mass

Update on current diagnosis and management of anaplastic thyroid carcinoma

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World Journal of Clinical Oncology 2023年第12期14卷 570-583页

作者： Efstathios T Pavlidis Ioannis N Galanis Theodoros E Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Well-differentiated thyroid carcinoma has a favorable prognosis with a 5-year survival rate of over 95%.However,the undifferentiated or anaplastic type accounting for<0.2%,usually in elderly individuals,exhibits a dismal prognosis with rapid growth and disappointing *** is the most aggressive form of thyroid carcinoma,with a median survival of 5 mo and poor quality of life(airway obstruction,dysphagia,hoarseness,persistent pain).Early diagnosis and staging are *** tools include biopsy(fine needle aspiration,core needle,open surgery),high-resolution ultrasound,computed tomography,magnetic resonance imaging,[(18)F]fluoro-D-glucose positron emission tomography/computed tomography,liquid biopsy and *** BRAF gene(BRAF-V600E and BRAF wild type)is the most often found molecular *** include the genes RET,KRAS,HRAS,and *** management policy is based on surgery,even debulking,chemotherapy(cisplatin or doxorubicin),radiotherapy(adjuvant or definitive),targeted biological agents and *** last two options constitute novel hopeful management modalities improving the overall survival in these otherwise condemned ***-programmed death-ligand 1 antibody immunotherapy,stem cell targeted therapies,nanotechnology achievements and artificial intelligence implementation provide novel promising *** mutations determine molecular pathways,thus indicating novel treatment strategies such as anti-BRAF,anti-vascular endothelial growth factor-A,and anti-epidermal growth factor *** with the combination of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib has been approved by the Food and Drug Administration in cases with BRAF-V600E gene mutations and is currently the standard *** neoadjuvant treatment followed by surgery ensures a twoyear overall survival of 80%.Prognostic factors for improved outcomes have been found to be younger age,earlier tumor stage and radiation thera

关键词： Thyroid diseases Thyroid cancers Anaplastic carcinoma Undifferentiated carcinoma neck mass Aggressive malignancies

An overview of the contemporary diagnosis and management approaches for anaplastic thyroid carcinoma

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World Journal of Clinical Oncology 2024年第6期15卷 674-676页

作者： Shu-Yue Zhou Lian-Xiang Luo The First Clinical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina The Marine Biomedical Research Institute Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina

Thyroid carcinoma is a complex disease with several types,the most common being well-differentiated and *** latter,“undifferentiated carcinoma”,also known as anaplastic thyroid carcinoma(ATC),is a highly aggr-essive malignant tumor accounting for less than 0.2%of all thyroid carcinomas and carries a poor prognosis with a median survival of 5 *** gene mutations are the most common molecular factor associated with this type of thyroid *** advances in targeted biological agents,immuno-therapy,stem cell therapy,nanotechnology,the dabrafenib/trametinib com-bination therapy,immune checkpoint inhibitors(ICI)and artificial intelligence offer novel treatment *** combination therapy of dabrafenib and tra-metinib is the current standard treatment for patients with BRAF-V600E gene ***,the dabrafenib/trametinib combination therapy,ICI,used alone or in combination with targeted therapies have raised some hopes for improving the prognosis of this deadly *** age,earlier tumor stage and radiotherapy are all prognostic factors for improved ***,therapeutic regimens should be tailored to the individual patient based on surveillance and epidemiological data,and a multidisciplinary approach is ess-ential.

关键词： Thyroid diseases Thyroid cancers Anaplastic carcinoma Undifferentiated carcinoma neck mass Aggressive malignancies