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Characterization on Modification and Biocompatibility of PCL Scaffold Prepared with near-field direct-writing Melt Electrospinning

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Chemical Research in Chinese Universities 2021年第3期37卷 578-583页

作者： CHEN Zhijun HAO Ming QIAN Xiaoming CHEN Wenyang ZENG Ming HUANG Juan LI Ruixin FAN Jintu LIU Yanbo School of Textile Science and Engineering State Key Laboratory of Separation Membranes and Membrane ProcessesTiangong UniversityTianjin300387P.R.China School of Textile Science and Engineering Key Laboratory of Textile Fiber and ProductMinistry of EducationWuhan Textile UniversityWuhan430200P.R.China Central Laboratory Tianjin300041P.R.China Tianjin Stomatological Hospital Tianjin Key Laboratory of Oral and Maxillofacial Function ReconstructionTianjin300041P.R.China

In this study,orthogonal experiments were designed to explore the optimal process parameters for preparing polycaprolactone(PCL)scaffolds by the near-field direct-writing melt electrospinning(NFDWMES)*** on the optimal process parameters,the PCL scaffolds with different thicknesses,gaps and structures were manufactured and the corresponding hydrophilicities were *** PCL scaffolds were modified by chitosan(CS)and hyaluronic acid(HA)to improve biocompatibility and *** Fourier transform infrared spectroscopy(FTIR)analysis and antibacterial experimental results show that the chitosan and hyaluronic acid adhere to the surface of PCL scaffolds,suggesting that the modification plays a positive role in biocompatibility and antibacterial *** PCL scaffolds were then employed as a carrier to culture *** morphology and distribution of the cells observed by a fluorescence microscope demonstrate that the modified PCL scaffolds have good biocompatibility,and the porous structure of the scaffolds is conducive to adhesion and deep growth of cells.

关键词： Melt electrospinning near-field direct-writing Tissue engineering scaffold Polycaprolactone Modification

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