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Activation of MAPK-mediated immunity by phosphatidic acid in response to positive-strand RNA viruses

Plant Communications 2024年第1期5卷 84-100页

作者： Jiayu Lin Jinpeng Zhao Linlin Du Pengkun Wang Bingjian Sun Chao Zhang Yan Shi Honglian Li Hangjun Sun The Engineering Research Center for Plant Health Protection Technology in Henan Province College of Plant ProtectionHenan Agricultural UniversityZhengzhouHenan 450046China

Increasing evidence suggests that mitogen-activated protein kinase(MAPK)cascades play a crucial role in plant defense against ***,the mechanisms that underlie the activation of MAPK cascades in response to viral infection remain *** this study,we discovered that phosphatidic acid(PA)repre-sents a major class of lipids that respond to Potato virus Y(PVY)at an early stage of *** identified nbplda1(Nicotiana benthamiana phospholipase Da1)as the key enzyme responsible for increased PA levels during PVY infection and found that it plays an antiviral role.6K2 of PVY interacts with nbplda1,lead-ing to elevated PA *** addition,nbplda1 and PA are recruited by 6K2 to membrane-bound viral repli-cation *** the other hand,6K2 also induces activation of the MAPK pathway,dependent on its interaction with nbplda1 and the derived *** binds to WIPK/SIPK/NTF4,prompting their phosphoryla-tion of ***,spraying with exogenous PA is sufficient to activate the MAPK ***-down of the MEK2-WIPK/SIPK-WRKY8 cascade resulted in enhanced accumulation of PVY genomic RNA.6K2 of Turnip mosaic virus and p33 of Tomato bushy stunt virus also interacted with nbplda1 and induced the activation of MAPK-mediated *** of function of nbplda1 inhibited virus-induced activation of MAPK cascades and promoted viral RNA ***,activation of MAPK-mediated immunity by nbplda1-derived PA is a common strategy employed by hosts to counteract positive-strand RNA virus infection.

关键词： Potato virus Y PVY positive-strand RNA virus +RNA virus phosphatidic acid PA nbplda1 MAPK WIPK/SIPK

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