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Engineering natural molecule-triggered genetic control systems for tunable gene-and cell-based therapies

Synthetic and Systems Biotechnology 2023年第3期8卷 416-426页

作者： Xinyi Wang Xuantong Zhou Liping Kang Yuqin Lai Haifeng Ye Synthetic Biology and Biomedical Engineering Laboratory Biomedical Synthetic Biology Research CenterShanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityDongchuan Road 500Shanghai 200241China

The ability to precisely control activities of engineered designer cells provides a novel strategy for modern precision *** adjustable gene-and cell-based precision therapies are recognized as next generation ***,the translation of these controllable therapeutics into clinical practice is severely hampered by the lack of safe and highly specific genetic switches controlled by triggers that are nontoxic and side-effect ***,natural products derived from plants have been extensively explored as trigger molecules to control genetic switches and synthetic gene networks for multiple *** controlled genetic switches could be further introduced into mammalian cells to obtain synthetic designer cells for adjustable and fine tunable cell-based precision *** this review,we introduce various available natural molecules that were engineered to control genetic switches for controllable transgene expression,complex logic computation,and therapeutic drug delivery to achieve precision *** also discuss current challenges and prospects in translating these natural molecule-controlled genetic switches developed for biomedical applications from the laboratory to the clinic.

关键词： Mammalian synthetic biology natural molecules Genetic switches Gene-and cell-based therapy Precision medicine

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natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

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Acta Pharmaceutica Sinica B 2021年第10期11卷 2995-3014页

作者： Arun Upadhyay Department of Biochemistry Central University of Rajasthan 305817India

Cells have different sets of molecules for performing an array of physiological *** acids have stored and carried the information throughout evolution,whereas proteins have been attributed to performing most of the cellular *** perform these functions,proteins need to have a unique conformation and a definite *** attributes are achieved by a highly coordinated protein quality control(PQC)system comprising chaperones to fold the proteins in a proper threedimensional structure,ubiquitin-proteasome system for selective degradation of proteins,and autophagy for bulk clearance of cell *** kinds of stresses and perturbations may lead to the weakening of these protective cellular machinery,leading to the unfolding and aggregation of cellular proteins and the occurrence of numerous pathological ***,modulating the expression and functional efficiency of molecular chaperones,E3 ubiquitin ligases,and autophagic proteins may diminish cellular proteotoxic load and mitigate various pathological *** medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating these pathways and reestablishing the lost proteostasis inside the cells to combat disease *** present article summarizes various similar reports and highlights the importance of the molecules obtained from natural sources in disease therapeutics.

关键词： Proteostasis Proteinopathies Chaperones Ubiquitin proteasome system Autophagy Cancer Neurodegeneration Ageing natural molecules Drug discovery

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Potential therapeutic effects of polyphenols in Parkinson's disease:in vivo and in vitro pre-clinical studies

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Neural Regeneration Research 2021年第2期16卷 234-241页

作者： Claudio Giuliano Silvia Cerri Fabio Blandini Laboratory of Cellular and Molecular Neurobiology IRCCS Mondino FoundationPaviaItaly

Parkinson's disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor *** the years,several factors have been discovered to play a role in the pathogenesis of this disease,in particular,neuroinflammation and oxidative *** date,the pharmacological treatments used in Parkinson's disease are exclusively *** this reason,in recent years,the research has been directed towards the discovery and study of new natural molecules to develop potential neuroprotective therapies against Parkinson's *** this context,natural polyphenols have raised much attention for their important anti-inflammatory and antioxidant properties,but also for their ability to modulate protein *** this review,we propose to summarize the relevant in vivo and in vitro studies concerning the potential therapeutic role of natural polyphenols in Parkinson's disease.

关键词： alpha-synuclein anti-inflammatory antioxidants natural molecules neuroprotection Parkinson's disease polyphenols syntomatic effect

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