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Medical Review 2023年第4期3卷 305-320页

作者： Xiangyu Zhao Minghao Lin Xiaojun Huang Peking University People's Hospital Peking University Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationNational Clinical Research Center for Hematologic DiseaseBeijingChina

natural killer(NK)cells possess innate abilities to effectively eliminate cancer cells.However,because of difficulties of proliferation and easy to be induced dysfunction in the setting of cancer post NK cell therapy,the curative effect of NK cell infusion has been constrained and not been widely applicable in clinical practice.The rapid development of biotechnology has promoted the development of NK cell therapy for cancer treatment.In this review,we will provide a comprehensive analysis of the current status and future prospects of NK cell therapy for cancer,focusing on the biological characteristics of NK cells,as well as strategies to enhance their targeting capabilities and overcome tumor immune suppression within the microenvironment.

关键词： natural killer cell therapy hematological malignancies solid tumors CAR-NK cell therapy

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Pandemic COVID-19:Current status and challenges of antiviral therapies

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Genes & Diseases 2020年第4期7卷 502-519页

作者： Winglam Chan Betsy He Xiong Wang Ming-Liang He Department of Biomedical Sciences City University of Hong KongHong KongChina Rensselaer Polytechnic Institute TroyNYUSA CityU Shenzhen Research Institute NanshanShenzhenChina

The pandemic COVID-19,caused by a new coronavirus SARS-CoV-2 infection,has infected over 12 million individuals and caused more than 55,200 death worldwide.Currently,there is no specific drug to treating this disease.Here we summarized the mechanisms of antiviral therapies and the clinic findings from different countries.Antiviral chemotherapies have been conducted by in multiple cohorts in different counties.Although FDA has fast approved remdesivir for treating COVID-19,it only speeds up recovery from COVID-19 with mildly reduced mortality.The chloroquine was suggested a potential drug against SARS-CoV-2 infection due to its in vitro antiviral effects,it is imperative high-quality data from worldwide clinical trials are necessitated for an approved therapy.In terms of hydroxychloroquine(HCQ)therapy,although WHO has stopped all the clinic trials due to its strong side-effects in COVID patients,large scale clinical trials with a long-term outcome follow-up may warrant HCQ and azithromycin combination in combating the virus.Convalescent plasma(CP)therapy suggested its safety use in SARS-CoV-2 infection;but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human origin.Further research should be conducted to define the exact mechanism of SARS-CoV-2 pathogenesis,suitable animal models or ex vivo human lung tissues aid in studying replication,transmission and spread of the novel viruses,thereby facilitating highly effective therapies.

关键词： Chloroquine Convalescent plasma therapy COVID-19 Hydroxychloroquine Ivermectin natural killer cell therapy Remdesivir SARS-CoV-2

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