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Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 143-148页

作者： Yang LU Shou-ying DU Xiao-lan CHEN Qing WU Xiao SONG Bing XU Yong-song ZHAI Department of Industrial Pharmacy School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Department of Chinese Pharmacy Guiyang College of Traditional Chinese Medicine Guiyang 550002 China

Both geniposide （Ge） and natural borneol （NB） are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography （HPLC） after intranasal administration of Ge （4 mg/kg） alone and combined with different doses （0.08, 0.8, and 8 mg/kg） of NB. The intravenous administration was given as a reference （4 mg/kg of Ge and 8 mg/kg of NB）. Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter （3-5 min vs. 40 min）; the peak concentration became higher （1.32-4.25 IJg/ml vs. 0.67 ug/ml）; and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.

关键词： Geniposide natural borneol Intranasal administration Intravenous administration Pharmacokinetics

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Research of Supercritical CO₂ Fluid Refined natural borneol

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American Journal of Plant Sciences 2016年第13期7卷 1794-1801页

作者： Hongcheng He Layun Deng Kedan He Qianwen Chen Hunan Academy of Forestry Changsha China Department of Chemistry Centre College Danville USA College of Materials Science and Engineering Central South University of Forestry & Technology Changsha China

In this study, with borneol fragments in the crystallized mother liquor of natural borneol used as the raw materials, supercritical carbon dioxide method is adopted for refining to get high purity borneol. The result of the experiment shows that the yield and purity are excellent with an extraction pressure of 11 MPa, an extracting temperature of 40°C, a carbon dioxide flow rate of 25 L·h-1 and an extraction time of 20 minutes. After detected by gas chromatography, the purity of the crystallization products could reach 96%.

关键词： natural borneol Supercritical Carbon Dioxide Purification Process

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