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natamycin in the treatment of fungal keratitis : a systematic review and Meta-analysis

International Journal of Ophthalmology(English edition) 2015年第3期8卷 597-602页

作者： Sheng Qiu Gui-Qiu Zhao Jing Lin Xue Wang Li-Ting Hu Zhao-Dong Du Qian Wang Cheng-Cheng Zhu Department of Ophthalmology Medical College Qingdao University Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To review published clinical studies examining the effect of natamycin in the treatment of fungal ***: We selected the publications in CENTRAL,MEDLINE, EMBASE, CNKI, and CBM. This study systematically reviewed published randomized controlled trials(RCTs) that compared natamycin to other antifungal agents, and conducted feasible Meta-analysis of efficacy results using Revman 5.2 ***: We included seven trials which were mainly carried out in developing countries of Asia, with five trials conducted in India, one each in China and Bangladesh. A total of 804 participants were randomized to following comparisons: 2% econazole versus 5%natamycin showed little difference in the effects of treatment of fungal keratitis [RR =0.99, 95% confidence interval(CI), 0.8 to 1.21]; chlorhexidine gluconate versus5% natamycin indicated that the results on healing of the ulcer at 21 d was less conclusive(RR=0.77, 95% CI, 0.55 to 1.08; I2=0%); 1% voriconazole versus 5% natamycin suggested that natamycin treatment appeared to be significantly better outcomes than voriconazole(regression coefficient =-0.18 log MAR; 95% CI,-0.30 to-0.05; P =0.006), especially in Fusarium cases(regression coefficient=-0.41 log MAR; 95% CI,-0.61 to-0.20; P natamycin versus fluconazole showed a significant difference in cure rate(χ2=5.048, P natamycin group was more effective than fluconazole in average period of therapy(t =7.94, P natamycin was a preferable choice in the treatment of fungal keratitis, especially in the early period of Fusarium cases.

关键词： eye infection fungal natamycin Metaanalysis

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Evaluation of natamycin in commercial dairy products by a green capillary zone electrophoresis method and confirmation with a Liquid Chromatography-Mass Spectrometry

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Food Bioscience 2022年第6期50卷 1047-1056页

作者： Senem Şanlı Sinem Kılıçarslan NurullahŞanlı Department of Chemistry Faculty of Science and ArtsUşak UniversityUŞAKTurkey Department of Food Engineering ChemistryFaculty of EngineeringUşak UniversityUŞAKTurkey Department of Chemistry and Physics Roger Williams UniversityOne Old Ferry RoadBristolRI02809USA

In the present study,a simple,rapid,sensitive,robust,convenient,economical and environmentally friendly Capillary Zone Electrophoresis(CZE)method based on the use of non-toxic chemicals was developed to monitor the concentrations of natamycin,which is used to prevent mold and yeast that may occur in cheese crust,cheese crumb,yogurt and ***,a LC-ESI-MS method was developed and used for confirmation as *** validated methods produced excellent results in terms of linearity(R2>0.999)and recovery values(ranging from 99.06%to 100.54%)and successfully applied for the analysis of natamycin,according to European regulations and Turkish Food Codex in 14 different brands of ayran,17 different brands of yogurt and 12 different brands of Kashar cheese collected from local *** demonstrated flexibility,sensitivity and selectivity,accuracy,robustness,and low *** developed CZE method is very advantageous because it is environmentally friendly and economical due to the analysis time and the absence of organic *** addition,the reliability of the study was increased by using the internal standard and possible errors were *** CZE and LC-MS methods provided good results for natamycin analysis and these methods can be used for natamycin analysis in dairy products and possible ***,embracing the primary concepts of green chemistry,the proposed technique can be taken into consideration friendly to the nature,sustainable and“reagent-free”.These assays are easily applicable as quality control methods for natural products and pharmaceuticals containing natamycin.

关键词： natamycin Capillary zone electrophoresis Green chemistry LC-ESI-MS Dairy Cheese Yogurt Pharmaceuticals

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Antifungal efficacy of natamycin in experimental fusarium solani keratitis

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 143-146页

作者： Xian-Hui Dong Wei-Juan Gao and Xiao-Ping He Laboratory of Spinal Cord Injury and Rehabilitation of Chengde Medical University Chengde 067000 Hebei Province China

AIM: To evaluate the efficacy of topical administration natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinical safety. METHODS: Fusarium solani was induced in the right eye of 30 New Zealand rabbits. Forty-eight hours after inoculation, the animals were divided into 3 different treatment groups, 10 rabbit eyes of each group: Group 1 (natamycin) treated with topical natamycin, group 2 (Natacyn) treated with topical Natacyn, group 3 (control) treated with topical saline solution. The eyes of each group was examined clinically with slit lamp using ulcer scoring system on day 4, 10, 15, and 21 for status of healing, corneal vascularisation, iritis, hypopyon and macular nebula. The findings were recorded on day 10 and day 21. RESULTS: Ulcer score on day 10, day 15, day 21: The score of natamycin group are 1.45 +/- 0.16, 1.08 +/- 0.11, 0.70 +/- 0.40. The score of Natacyn group are 1.35 +/- 0.12, 1.10 +/- 0.12, 0.65 +/- 0.35. the score of control group are 1.30 +/- 0.08, 3.63 +/- 0.28, 3.80 +/- 0.16. natamycin group and Natacyn group were different from control group (P natamycin group and Natacyn group. Status of healing on day 10 and day 21: The cure rate of the natamycin group is 90% on day 10, and 100% on day 21. The cure rate of the Natacyn group is 80% on day 10, and 100% on day *** group and Natacyn group were different from control group (Pnatamycin group and Natacyn group. Corneal vascularisation, iritis, hypopyon and macular nebula on day 10 and day 21: in natamycin group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 2,0,0,2. In Natacyn group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 1,0,0,2. In control group, the number of the eyes which have Corner vascularisati

关键词： fusarium solan fungal keratitis natamycin natacyn

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Space-flight Mutation of Streptomyces gilvosporeus for Enhancing natamycin Production

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Chinese Journal of Chemical Engineering 2007年第5期15卷 720-724页

作者：梁景乐林建平徐志南苏薇岑沛霖 Institute of Bioengineering College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China Shandong Lukang Pharmaceutical Co. Jining 272021 China

Mutants of the strain producing natamycin, Streptomyces gilvosporeus, were obtained after space-flight mutation. With respect to the sand spores and slant spores, the mutation ratios were up to 67.6% and 78.3% and the survival ratio was 43.1% and 3.0%, respectively. An improved mutant producing natamycin, S. gilvosporeus LK-45, was screened, which showed natamycin productivity of 1420mg·L^-1. A mutant resistant to 2-deoxy glucose, *** LK-119, was further obtained using a＇rational screening procedure. The natamycin productivity of 1940mg·L^-1 was achieved when glucose was used as the carbon source.

关键词： space-flight mutation Streptomyces gilvosporeus natamycin rational screening 2-deoxy glucose

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Application of a chitosan coating as a carrier for natamycin to maintain the storage quality of ground cherry(Physalis pubescens L.)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 807-815页

作者： Xiao-lei HAO Jiao-jiao ZHANG Xi-hong LI Wei WANG College of Food Engineering and Biotechnology Tianjin University of Science and TechnologyTianjin 300457China

Ground cherry(Physalis pubescens L.) is a kind of berry fruit favored by consumers in China; however, this fruit is particularly vulnerable to physiological senescence and pathogen attack during the traditional cold storage period. In order to maintain storage quality, a 1.5%(w/w) chitosan(CS) water solution containing 50 mg/L of natamycin(NA) was introduced. After all treatments were completed, the fruit was stored at 0°C and sampled every 10 d. At each sampling date, the following tests were performed: mold and yeast analyses; enzyme activity and content analyses which included superoxide dismutase(SOD), ascorbate peroxidase(APX), and malondialdehyde(MDA); and color analysis. In addition, a sensory evaluation was carried out for quality assessment at the end of the storage period. The results showed that the application of a chitosan coating combined with natamycin(CSNA) enhanced the activity of superoxide dismutase(SOD) and ascorbate peroxidase(APX), reduced the physiological rate of senescence, and inhibited pathogen attack. Thus, CSNA treatment can maintain ground cherries at an acceptable level of storage quality for 50 d.

关键词： Chitosan coating natamycin Storage quality Physalis pubescens L

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natamycin及其在食品中应用的研究

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食品科技 2000年第6期25卷 43-44页

作者：汤凤霞乔长晟宋卫东宁夏农学院食品系银川750105 北京奥内特乳品有限公司 101101

介绍了 natamycin的性质、特点、防腐作用及其在食品中的应用。

关键词： natamycin 真菌应用生物防腐剂食品抑菌作用

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natamycin的生物学性质及其在乳品工业中的应用

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食品科技 2007年第4期32卷 4-6页

作者：王喜波刘杨姜云庆东北农业大学食品学院哈尔滨150030 东北农业大学国际文化教育学院哈尔滨150030

阐述了Streptomyces natalensis次级代谢产物——natamycin的生物学性质、抑菌机理、安全性及其在乳制品中应用的最新研究进展。natamycin抑制(杀灭)真菌具有广谱、高效的特点,是一种极具发展潜力的天然生物食品防腐剂。

关键词： natamycin 防腐剂乳酪酸奶

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Development and Characterisation of natamycin Mini-Matrices Prepared by Hot-Melt Extrusion for Vaginal Delivery

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Journal of Materials Science and Chemical Engineering 2018年第3期6卷 47-54页

作者： Betül Rumeysa Temel Isik Ozgüney Department of Pharmaceutical Technology Faculty of PharmacyEge UniversityIzmirTurkey Department of Pharmaceutical Technology Faculty of PharmacyIzmir Katip Celebi UniversityIzmirTurkey

In this study, bioadhesive mini-matrices of natamycin were prepared for vaginal application by hot-melt extrusion. In addition, melt viscosity measurements, thermogravimetric analysis, in vitro drug release studies and in vitro mucoadhesion test were performed. High molecular weight grades of KlucelTM hydroxypropylcellulose were used as a thermoplastic polymer. TEC and PEG 400 were chosen as plasticizer. According to the obtained results of melt viscosity measurements, the maximum torque of extrudates prepared using PEG 400 increased with increasing drug loading. The thermo-gravimetric analyses showed that natamycin is stable up to 198℃ and this result gives the opportunity to hot melt extrussion process at 90℃. In vitro drug release results showed that the release was extended up to 72 hours and drug release rate increased with increasing drug loading. In respect to the in vitro mucoadhesion test results, the values of work of mucoadhesion were found high as 771,977 ***, 753,199 ***, 686,356 *** for the prepared hot melt extruded mini-matrices. Our results showed that the developed formulations were found worthy of further studies.

关键词： Hot Melt Extrusion natamycin Controlled Release Bioadhesive Vaginal Delivery

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抗菌素natamycin对酵母菌生长的影响

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中国农业大学学报 2004年第1期9卷 96-99页

作者：梁建芬李勇中国农业大学食品科学与营养工程学院北京100083

考察了natamycin对酵母菌生长繁殖的影响 ,确定了其最低抑菌浓度及最佳添加时间。结果表明 :natamycin对酵母的生长繁殖有明显的抑制作用 ,其最小抑菌浓度为 2 5 μg·mL-1;其抑菌效果与其浓度成正相关 ,与加入natamycin时酵母菌的初... 详细信息

考察了natamycin对酵母菌生长繁殖的影响 ,确定了其最低抑菌浓度及最佳添加时间。结果表明 :natamycin对酵母的生长繁殖有明显的抑制作用 ,其最小抑菌浓度为 2 5 μg·mL-1;其抑菌效果与其浓度成正相关 ,与加入natamycin时酵母菌的初始活菌数成负相关 ;在酵母菌生长延迟期加入natamycin抑菌效果明显好于稳定期加入。

关键词：抗菌素 natamycin 酵母菌生长繁殖最低抑菌浓度最佳添加时间食品添加剂

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The Fluorescence Immunochromatographic Strips for natamycin and Its Application in Food Safety Detection

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Agricultural Biotechnology 2019年第6期8卷 104-105页

作者： Wei ZHENG Yongfeng LIU Yafei XU Zhijun QIU Xinyue LI Beilun Customs Ningbo 315000China Zhenhai District Agricultural Technology Extension Station Ningbo 315000China

A fluorescence immunochromatographic strip was developed in this study for natamycin detection in food. The results showed that the best amount of labeled antibody was 10 μg, for every 50 μl of fluorescent microspheres with a 2.5%(w/v) concentration. This labeled antibody was diluted for 10 times, and the diluted solution was dispensed into conjugate pad at the amount of 3 μl/cm. The concentrations of natamycin labeled BSA for test line and goat anti-mouse IgG for control line were 2.0 and 1 mg/ml, respectively, which performed best. With the best conditions, the limit of detection was 1 ng/ml, the linearity ranged from 2 to 100 ng/ml, the recovery was about 80% to 120%, and the CV was below 23%.

关键词： Food safety detection natamycin Fluorescence immunochromatographic assay

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