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Preparation and evaluation of mucoadhesive bio-flexy films from Cocos nucifera biopolymer using tiagabine moiety

Precision Medicine Research 2021年第4期3卷 4-15页

作者： Sugandha Varshney N.V.Satheesh Madhav Guru Nanak College of Pharmaceutical Sciences BanshiwalaJhajraDehradunUttarakhand248007India Formulation Research Development Vital Therapeutics and FormulationsPvt.Ltd.Telangana500003India

This research work deals with formulation and evaluation of nanosized tiagabine loaded bio-flexy films consisting of Cocos nucifera biopolymer(isolated from coconut kernels).Prepared formulations were administered through soft palatal route for brain targeting for epilepsy *** palate,part of oral mucosa serves as novel drug delivery platform and mucoadhesive site for systemic drug *** provides sustained and controlled drug delivery system,does not interfere with patient’s regular activities like talking,eating,drinking,*** bypasses first-pass metabolism in the liver,reduces dose frequency and minimizes drug’s side ***,anticonvulsant drug possesses t1/2:7-9 h(low);Protein binding:96%;Water solubility:22 mg/L,acts as selective gamma amino butyric acid(GABA)reuptake *** nucifera biopolymer used as bio-excipient to prepare bio-flexy films due to its biodegradability,biocompatibility,non-toxicity,non-irritantancy on soft palatal surface along with inbuilt filmability,mucoadhesive *** drug loaded bio-flexy films were formulated using standard solvent casting ***-flexy films were prepared using varying ratios of nanosized tiagabine:isolated Cocos nucifera biopolymer(FCT1-FCT6).These prepared formulations were compared with same ratios of nanosized tiagabine:sodium carboxyl methyl cellulose standard polymer flexy films(FET1-FET6).The%yield of Cocos nucifera biopolymer was found to be 10.2±0.04%.Thickness of nanosized tiagabine loaded bio-flexy films containing Cocos nucifera biopolymer(FCT1-FCT6)was ranging from 0.026±0.04 mm to 0.040±0.02 mm;Folding endurance:84-107;Surface pH:7.01±0.04 to 7.01±0.02;Weight uniformity:0.012±0.04 to 0.020±0.02;Drug content uniformity:69.5±0.35%to 72.9±0.26%;Swelling percentage:65±0.5%to 73±0.2%;Percentage moisture uptake(PTU):2.0±0.14%to 2.8±0.12%;Mucoadhesivity:20-90 min;Mucoretentivity:60-180 *** drug release pattern for formulations FCT1-FCT6 containing Cocos nuci

关键词： nanosized tiagabine Soft palatal delivery Mucoadhesive Cocos nucifera Biopolymer Bio-flexy films

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