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nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

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Bioactive Materials 2022年第2期7卷 109-123页

作者： Yide He Zhe Li Xin Ding Boya Xu Jinjin Wang Yi Li Fanghao Chen Fanhui Meng Wen Song Yumei Zhang State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases Department of ProsthodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Huaian Stomatological Hospital NanjingChina State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases Department of PeriodontologySchool of StomatologyThe Fourth Military Medical UniversityXi’anChina State Key Laboratory of Military Stomatology Department of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina

Macrophages and osteoclasts are both derived from monocyte/macrophage lineage,which plays as the osteoclastic part of bone *** they are regulated by bone implant surface nanoarchitecture and involved in osseointegration,the beneath mechanism has not been simultaneously analyzed in a given surface model and their communication with osteoblasts is also ***,the effect of implant surface topography on monocyte/macrophage lineage osteoclastogenesis and the subsequent effect on osteogenesis are systematically *** nanoporous surface is fabricated on titanium implant by etching and anodizing to get the nanotubes *** early bone formation around implant is significantly accelerated by the nanoporous surface in ***,the macrophage recruitment and osteoclast formation are increased and decreased ***,the integrin mediated FAK phosphorylation and its downstream MAPK pathway(p-p38)are significantly downregulated by the nanoporous surface,which account for the inhibition of *** addition,the nanoporous surface can alleviate the inhibition of osteoclasts on osteogenesis by changing the secretion of clastokines,and accelerate bone regeneration by macrophage cytokine *** conclusion,these data indicate that physical topography of implant surface is a critical factor modulating monocyte/macrophage lineage commitment,which provides theoretical guidance and mechanism basis for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis.

关键词： nanoporous implant Osteogenesis Osteoclastogenesis FAK phosphorylation MAPK

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