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Science China Chemistry 2021年第12期64卷 2218-2229页

作者： Jiamin Ye Qinrui Fu Luntao Liu Lanlan Chen Xuan Zhang Qingqing Li Zhi Li Lichao Su Rong Zhu Jibin Song Huanghao Yang MOE Key Laboratory for Analytical Science of Food Safety and Biology Ministry of EducationCollege of ChemistryFuzhou UniversityFuzhou350108China

Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in ***,access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force,preventing their deep penetration into the tissues of the tumors,and hindering the use of PA and US for deep tumor *** concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids,thereby conducting assigned ***,US-propelled Janus mesoporous SiO_(2)partially coated gold nanorods(Au NR-mSiO_(2))were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas *** US irradiation,2,2-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)loaded in mSiO_(2)(Au NR-mSiO_(2)/AIPH)generated N_(2)microbubbles with high efficiency to achieve nanomotor *** to the deep penetration of US,the nanomotors exhibited a capability to travel deep within sites of tumors,providing enhanced PA/US imaging inside the ***,the nanomotor based cancer therapy was demonstrated through synergistic N_(2)gas and sonodynamic *** US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors.

关键词： nanomotor NIR-Ⅱphotoacoustic imaging ultrasound sonodynamic therapy gas therapy

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Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2924-2936页

作者： Wenqi Yu Ruyi Lin Xueqin He Xiaotong Yang Huilin Zhang Chuan Hu Rui Liu Yuan Huang Yi Qin Huile Gao Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China Department of Orthopedics Zhuhai HospitalJinan UniversityZhuhai People’s HospitalGuangdong 519000China

Solid tumors always exhibit local hypoxia,resulting in the high metastasis and inertness to *** of hypoxic tumor microenvironment(TME)is considered a potential therapy compared to directly killing tumor ***,the insufficient oxygen delivery to deep tumor and the confronting Warburg effect"compromise the efficacy of hypoxia ***,we construct a cascade enzyme-powered nanomotor(NM-si),which can simultaneously provide sufficient oxygen in deep tumor and inhibit the aerobic glycolysis to potentiate anti-metastasis in ***(Cat)and glucose oxidase(GOx)are co-adsorbed on our previously reported CAuNCs@HA to form self-propelled nanomotor(NM),with hexokinase-2(HK-2)siRNA further condensed(NM-si).The persistent production of oxygen bubbles from the cascade enzymatic reaction propels NM-si to move forward autonomously and in a controllable direction along H_(2)O_(2) gradient towards deep tumor,with hypoxia successfully alleviated in the *** autonomous movement also facilitates NM-si with lysosome escaping for efficient HK-2 knockdown to inhibit *** vivo results demonstrated a promising anti-metastasis effect of commercially available albumin-bound paclitaxel(PTX@HSA)after pre-treated with NM-si for TME *** cascade enzyme-powered nanomotor provides a potential prospect in reversing the hypoxic TME and metabolic pathway for reinforced anti-metastasis of chemotherapy.

关键词： nanomotor Microenvironment modulation Hypoxia Aerobic glycolysis Triple negative breast cancer Anti-metastasis Enzyme-powered Chemotherapy

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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean Carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

Designing bioactive micro-/nanomotors for engineered regeneration

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Engineered Regeneration 2021年第1期2卷 109-115页

作者： Lijun Cai Dongyu Xu Hanxu Chen Li Wang Yuanjin Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China

Micro/nanoscale motors(MNMs)have been regarded as promising tools in the field of engineered regeneration due to unique property of autonomous ***,a review on the advancements of MNMs in the area of engineered regeneration is presented,covering aspects from their propulsion mechanisms to their frontiers in engineered regeneration,listing the revolutionary applications in biosensing,medical imaging,drug delivery and tissue ***,challenges and future directions of MNMs are finally discussed on the basis of the achievements.

关键词： Micromotor nanomotor Engineered regeneration Propulsion mechanisms

Artificial nanomotors: Fabrication, locomotion characterization, motion manipulation, and biomedical applications

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Interdisciplinary Materials 2022年第2期1卷 256-280页

作者： Liangmeng Wang Xiaomeng Hao Zhixue Gao Zili Yang Yi Long Ming Luo Jianguo Guan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of TechnologyWuhanPeople's Republic of China School of Materials Science&Engineering Nanyang Technological UniversitySingaporeSingapore

Artificial nanomotors are nanoscale machines capable of converting surrounding other energy into mechanical motion and thus entering the tissues and cells of *** hold great potential to revolutionize the diagnosis and treatment of diseases by actively targeting the lesion location,though there are many new challenges that arise with decreasing the size to *** review sum-marizes and comments on the state-of-the-art artificial nanomotors with ad-vantages and *** starts with the fabrication methods,including common physical vapor deposition and colloidal chemistry methods,followed by the locomotion characterization and motion ***,the in vitro and in vivo biomedical applications are introduced in *** challenges and future prospects are discussed at the end.

关键词： biomedical application fabrication locomotion characterization motion manipulation nanomotor

One-dimensional micro/nanomotors for biomedicine:delivery,sensing and surgery

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Biomaterials Translational 2020年第1期1卷 18-32页

作者： Jiawang Guo Yuan Lin The State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin ProvinceChina.

The rapid development of artificial micro/nanomachines brings promising strategies to overcome challenges in biomedicine,including delivery,sensing and ***-dimensional(1D)micro/nanomotors are one of the most attractive micro/nanomachines due to their high specific surface area,powerful impetus and weak rotation *** this review,different propulsion mechanisms and motion control strategies of 1D micro/nanomotors are summarized,and recent efforts towards their fabrication methods and biomedical applications are *** envision the multidisciplinary research efforts in the field of 1D micro/nanomotors will pave their way to practical applications in bioimaging and biomedicine.

关键词： biomedicine micromotor nanomotor one-dimensional

Recent progress on the design and fabrication of micromotors and their biomedical applications

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Bio-Design and Manufacturing 2018年第4期1卷 225-236页

作者： Wensen Jiangl Liang Ma Xiaobin Xul School of Materials Science and Engineering Tongji UniversityShanghai 201804China State Key Laboratory of Fluid Power and Mechatronic Systems &School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China

The advancement in the micro-/nanofabrication techniques has greatly facilitated the development of micromotors.A variety of micromotors have been invented with powerful functions,which have attracted a broad range of interests from chemistry, physics,mechanics,biology and *** this paper,we reviewed recent progress in micromotors and highlighted representative *** mechanisms of micromotors by internal and external energy sources were *** described general fabrication strategies of the popular micromotors (wire,tubular,helical and Janus)including bottom-up and top-down *** the application section,we primarily focused on the biological applications,such as biological cargo delivery, biosensing and *** last,we discussed the current challenges and provided future prospects.

关键词： Micromotor nanomotor Electric tweezers Drug delivery Nanorobot Micromachine

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The prototypes of nanozyme-based nanorobots

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Biophysics Reports 2020年第6期6卷 223-244页

作者： Jiaying Xie Yiliang Jin Kelong Fan Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of Sciences School of Future Technology University of Chinese Academy of Sciences Academy of Medical Sciences Zhengzhou University

Artificial nanorobot is a type of robots designed for executing complex tasks at nanoscale. The nanorobot system is typically consisted of four systems, including logic control, driving, sensing and functioning. Considering the subtle structure and complex functionality of nanorobot, the manufacture of nanorobots requires designable, controllable and multi-functional nanomaterials. Here, we propose that nanozyme is a promising candidate for fabricating nanorobots due to its unique properties,including flexible designs, controllable enzyme-like activities, and nano-sized physicochemical characters. Nanozymes may participate in one system or even combine several systems of nanorobots. In this review, we summarize the advances on nanozyme-based systems for fabricating nanorobots, and prospect the future directions of nanozyme for constructing nanorobots. We hope that the unique properties of nanozymes will provide novel ideas for designing and fabricating nanorobotics.

关键词： Logic gate Nanozyme Nanorobot nanomotor Motion control

Tracking the Rotational Dynamics of Single Nanorods with Surface Plasmon Resonance Microscopy

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Tracking the Rotational Dynamics of Single Nanorods with Sur...