检索结果-南通市图书馆

Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer’s disease

引用

Neural Regeneration Research 2023年第1期18卷 226-232页

作者： Lin Wang Bi-Qiang Zhou Ying-Hong Li Qian-Qian Jiang Wei-Hong Cong Ke-Ji Chen Xiao-Min Wen Zheng-Zhi Wu The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhen Institute of GeriatricsShenzhenGuangdong ProvinceChina The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhenGuangdong ProvinceChina China Academy of Chinese Medical Sciences Xiyuan HospitalBeijingChina School of Chinese Medicine Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that berberine has neuroprotective effects against Alzheimer’s disease,including antagonizing tau phosphorylation,and inhibiting acetylcholinesterase activity and neural cell ***,its low bioavailability and adverse reactions with conventional administration limit its clinical *** this study,we prepared berberine nanoliposomes using liposomes characterized by low toxicity,high entrapment efficiency,and biodegradability,and modified them with ***-modified berberine nanoliposomes had uniform particle size and high entrapment *** used the lactoferrin-modified berberine nanoliposomes to treat a mouse model of Alzheimer’s disease established by injection of amyloid-beta 1-42 into the lateral ***-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus,reduced tau over-phosphorylation in the cerebral cortex,and improved mouse *** findings suggest that modification with lactoferrin can enhance the neuroprotective effects of berberine nanoliposomes in Alzheimer’s disease.

关键词： acetylcholinesterase Alzheimer’s disease apoptosis berberine brain targeting lactoferrin nanoliposomes neuroprotective effects Tau phosphorylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Near-infrared light(NIR)-responsive nanoliposomes combining photodynamic therapy and chemotherapy for breast tumor control

引用

Chinese Chemical Letters 2022年第4期33卷 1923-1926页

作者： Guangzhao Lu Xiqing Gao He Zhang Yeye Zhang Yuan Yu Zhiguo Sun Wei Li Wei Wu Ying Lu Hao Zou Department of Pharmaceutical Sciences School of PharmacyNaval Medical UniversityShanghai 200433China Department of Pharmacy Zhongshan HospitalFudan UniversityShanghai 200032China Laboratory of Nano Biomedicine&International Joint Cancer Institute Naval Medical UniversityShanghai 200433China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 200032China

Light-responsive carriers have been used for the controlled release of antitumor drugs in recent ***, most light-responsive vectors require high-energy ultraviolet or visible light to achieve local drug release, and ultraviolet light would cause cellular damage. Near-infrared light has a deeper tissuepenetration depths and minimal harm to tissues, but it is difficult to cleave the chemical bond *** aim of this study is to develop a novel near-infrared light-responsive carrier for local release of antitumor drugs. Unsaturated phospholipids can be oxidized by singlet oxygen to achieve liposomal drug release, and singlet oxygen can be produced by photosensitizer under light irradiation. A new near-infrared light-responsive nanoliposome was designed that imparts light-triggered local drug release. nanoliposomes, which were composed of matrix phospholipids and unsaturated phospholipids, were prepared by ammonium sulfate gradient method, and loaded with antitumor drug doxorubicin(DOX) and photosensitizer 1,4,8,11,15,18,22,25-octabutoxypalladium phthalocyanine. Under near-infrared light, photosensitizers could produce singlet oxygen and damage tumor cells by photodynamic therapy. Simultaneously, the unsaturated phospholipids were oxidized by singlet oxygen and result in DOX release, causing sustained cell damage by chemotherapy. Near-infrared light-responsive nanoliposomes exhibit enhanced anticancer activity owing to combined treatment of photodynamic therapy and chemotherapy. A new platform is thus offered for designing effective intracellular drug-release systems, holding great promise for future cancer therapy.

关键词： Near-infrared light Unsaturated phospholipids nanoliposomes Photosensitizer Singlet oxygen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle

引用

Bioactive Materials 2023年第2期20卷 166-178页

作者： Shuming Sun Han Liu Yan Hu Yanpeng Wang Mingri Zhao Yijun Yuan Yafei Han Yingying Jing Jin Cui Xiaoxiang Ren Xiao Chen Jiacan Su Molecular Biology Research Center Center for Medical GeneticsHunan Province Key Laboratory of Basic and Applied HematologySchool of Life SciencesCentral South UniversityChangsha410078China Institute of Translational Medicine Shanghai UniversityShanghai200444China Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsh1Hunan410013China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan410082China Department of Orthopedics Traum1 Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China

Skeletal muscle disorders have posed great threats to *** delivery of drugs and oligonucleotides to skeletal muscle is *** can improve targeting *** this study,for the first time,the human skeletal muscle-specific ssDNA aptamers(HSM01,etc.)were selected and identified with Systematic Evolution of Ligands by Exponential Enrichment(SELEX).The HSM01 ssDNA aptamer preferentially interacted with human skeletal muscle cells in *** in vivo study using tree shrews showed that the HSM01 ssDNA aptamer specifically targeted human skeletal muscle ***,the ability of HSM01 ssDNA aptamer to target skeletal muscle cells was not affected by the formation of a disulfide bond with nanoliposomes in vitro or in vivo,suggesting a potential new approach for targeted drug delivery to skeletal muscles via ***,this newly identified ssDNA aptamer and nanoliposome modification could be used for the treatment of human skeletal muscle diseases.

关键词： Aptamer SELEX Human skeletal muscle Target delivery nanoliposomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than Doxil?

引用

Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 385-396页

作者： Ruoshi Zhang Yingxi Zhang Yue Zhang Xin Wang Xuanming Gao Yuyan Liu Xuanbo Zhang Zhonggui He Dun Wang Yongjun Wang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China

Although the appearance of Doxil alleviated the cardiotoxicity of DOX, the progression-free survival of patients was not prolonged compared with traditional medication regimens, and side effects such as hand-foot syndrome has occurred. In order to solve this dilemma, we have designed a novel co-delivery strategy to construct a co-loaded liposome of berberine(BER) and doxorubicin(DOX), which was called Lipo Be Do. The optimal synergistic ratio of the two drugs was screened by cell cytotoxicity experiments in vitro, and the optimal attenuation ratio was further determined by in vivo cardiac H&E staining pathological sections. The optimal combination treatment caused a robust increase in apoptotic cells of 4T1, as compared to drug alone treatment. The prepared co-loaded liposome, Lipo Be Do, had high encapsulation efficiency and good stability. The nanoliposome carrier controlled the biological fate of the drugs and maintained a pre-defined optimal ratio in vivo. The Lipo Be Do significantly inhibited tumor growth in 4T1 murine mammary carcinoma model compared with Doxil(P < 0.05), and completely overcame the myocardial rupture toxicity caused by Doxil in mice. Our co-loaded liposome delivery platform technology provided a new direction for the clinical treatment of triple-negative breast cancer and the safe application of DOX.

关键词： Berberine Doxorubicin nanoliposomes Remote loading Combination therapy Cardiotoxity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential of pectin-chitosan based composite films embedded with quercetin-loaded nanofillers to control meat associated spoilage bacteria

引用

Food Bioscience 2023年第3期53卷 655-666页

作者： Syed Muhammad Afroz Ali Taskeen Niaz Anas Munir Ramla Shahid Saima Shabbir Tayyaba Noor Muhammad Imran Department of Biosciences Faculty of SciencesCOMSATS University IslamabadPark RoadIslamabadPakistan Department of Materials Science and Engineering Institute of Space TechnologyIslamabad44000Pakistan School of Chemical and Materials Engineering(SCME) National University of Sciences and Technology(NUST)IslamabadPakistan

Increasing consumer demands for healthy,minimally processed,contamination-free food with extended shelf life have exerted pressure on the food industry to search for more effective and biodegradable packaging materials against spoilage ***-chitosan based nanocomposite films were developed and evaluated for the impacts of antimicrobial-loaded nanofillers[quercetin-loaded nano-liposomes(QNLs)]on the physico-mechanical,thermal,and antibacterial properties against meat-associated spoilage *** were observed with an average size of 191±7 nm by dynamic light scattering with a negative zeta-potential value of-37±5.7 *** electron microscopy revealed round and smooth surface morphology of *** spectroscopic analyses confirmed the encapsulation of quercetin in liposomes via weak electrostatic or hydrophobic *** addition of nanofillers in composite films increased the tensile strength(9.74±0.26 MPa)and Young’s modulus(24.17±0.64 MPa)of the nano-active films as compared to active films(2.49±0.02 MPa and 5.04±0.04 MPa),***,opacity(3.10±0.04)and moisture content(31.03%±1.81%)values of nano-active films were lesser as compared to non-active films(5.35%±0.07%and 84.24%±0.45%respectively)owing to the hydrophobic nature of *** analyses performed by TGA and DSC confirmed the thermal stability of nano-active ***-active films exhibited excellent antimicrobial potential(spot-on-lawn and quantitative food application assays)against multidrug-resistant meat pathogens including Escherichia coli,Listeria monocytogenes and Salmonella ***,pectin-chitosan based nano-active films have promising applications for the preservation of meat products from spoilage bacteria.

关键词： Nano-active packaging Pectin Chitosan Quercetin nanoliposomes Antimicrobial films

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A nano-enhanced vaccine for metastatic melanoma immunotherapy

引用

Cancer Drug Resistance 2022年第3期5卷 829-845页

作者： Katelyn E.Salotto Walter C.Olson Jr Karlyn E.Pollack Anuradha Illendula Elishama Michel Sydney Henriques Todd Fox Susan Walker Marya Dunlap-Brown Craig L.Slingluff Jr Mark Kester Helena W.Snyde School of Engineering and Applied Sciences University of VirginiaVirginiaVA 22904USA Department of Surgery School of MedicineUniversity of VirginiaVirginiaVA 22903USA Department of Dermatology School of MedicineUniversity of VirginiaVirginiaVA 22903USA Department of Pharmacology School of MedicineUniversity of VirginiaVirginiaVA 22903USA University of Virginia nanoSTAR Institute VirginiaVA 22903USA Molecular Immunologic&Translational Sciences(MITS)Core School of MedicineUniversity of VirginiaVirginiaVA 22903USA Department of Materials Science School of Engineering and Applied SciencesUniversity of VirginiaVirginiaVA 22903USA

Aim:Despite the huge advancements in cancer therapies and treatments over the past decade,most patients with metastasized melanoma still die from the *** poor prognosis largely results from resistance to conventional chemotherapies and other cytotoxic *** have previously identified 6 antigenic peptides derived from melanomas that have proven efficacious for activating CD4+T cells in clinical trials for *** aim was to improve pharmacodynamics,pharmacokinetic and toxicological parameters by individually encapsulating each of the 6 melanoma helper peptides within their own immunogenic ***:We modified these liposomes as necessary to account for differences in the peptides’chemical properties,resulting in 3 distinct *** further enhance immunogenicity,we also incorporated KDO2,a TLR4 agonist,into the lipid bilayer of all nanoliposome *** then conducted in vivo imaging studies in mice and ex vivo cell studies from 2 patient samples who both strongly expressed one of the identified ***:We demonstrate that these liposomes,loaded with the different melanoma helper peptides,can be readily mixed together and simultaneously delivered without toxicity in *** liposomes are capable of being diffused to the secondary lymphoid organs very quickly and for at least 6 *** addition,we show that these immunogenic liposomes enhance immune responses to specific peptides ex ***:Lipid-based delivery systems,including nanoliposomes and lipid nanoparticles,have now been validated for pharmacological(small molecules,bioactive lipids)and molecular(mRNA,siRNA)therapeutic ***,the utility of these formulations as cancer vaccines,delivering antigenic peptides,has not yet achieved the same degree of commercial ***,we describe the novel and successful development of a nanoliposome-based cancer vaccine for *** vaccines help to circumvent drug resistance by increasing a

关键词： nanoliposomes nanoscale drug delivery cancer vaccines metastasized melanoma peptides melanoma drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antimicrobial activity of drug-loaded nanoparticles on Enterococcus faecalis in vitro

Antimicrobial activity of drug-loaded nanoparticles on Enter...

引用

中华口腔医学会第14次全国口腔医学学术会议（2012年会）

作者： Hu Rui School of Stomatology,Central South University,Changsha,Hunan Province,China (410008)

Objective:The study was aimed to compare the antimicrobial activity of Erythromycin nano-hydroxyapatite microspheres(nHA-PHBV-PEG-EM), Erythromycin nanoliposome(EMNP) and Calcium hydroxide(Ca(OH)2) on

关键词： enterococcusfaecalis erythromycin nano-hydroxyapatite nanoliposomes antimicrobial activity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain

Nasal delivery of nanoliposome-encapsulated ferric ammonium ...

引用

中国神经科学学会第十二届全国学术会议

作者： Xue-Ling GUO Hong ZHENG Yue-Tong GUO Yan WANG Gregory J.ERSON Yun-Zhe CI Peng YU Lina GENG Yan-Zhong CHANG Laboratory of Molecular Iron Metabolism Key laboratory of Animal PhysiologyBiochemistry and Molecular Biology of Hebei Province College of Life Sciences Hebei Normal University College of Chemistry and Material Science Hebei Normal University

Background Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow efficient iron delivery to the brain due to the presence of the blood-brain barrier. So an easily delivered iron formulation with high absorption efficiency potentially could find widespread application in iron deficient infants. Methods FAC nanoliposomes（FAC-LIP） were prepared with ethanol injection method, and then characterized with ultraviolet spectrophotometry, transmission electron microscopy and dynamic light scatting. After nasal delivery of FAC-LIP, the brain iron contents were detected with micro-X-ray fluorescence, inductively coupled plasma mass spectroscopy, western blotting method, and the side effects were examined with TUNEL, quantitative real-time PCR and biochemical analysis. Results In this study, we have developed and characterized a nanovesicular formulation of ferric ammonium citrate（ferric ammonium citrate nanoliposomes, FAC-LIP） and have shown that it can increase brain iron levels in rats following nasal administration. FAC was incorporated into liposomes with high efficiency（97%） and the liposomes were small（40 nm） and stable. Following intranasal delivery in rats, FAC-LIP significantly increased the iron content in the olfactory bulb, cerebral cortex, striatum, cerebellum and hippocampus, and was more efficient at doing so than FAC alone. No signs of apoptosis or abnormal cell morphology were observed in the brain following FAC-LIP administration, and there were no significant changes in the levels of SOD and MDA, except in the cerebellum and hippocampus. No obvious morphological changes were observed in lung epithelial cells or tracheal mucosa after nasal delivery, suggesting that the formulation was not overtly toxic. Conclusions In this study, nanoscale FAC-LIP proved an effective system delivering iron to the brain, with high

关键词： Nasal delivery FAC nanoliposomes ICP-MS Mmicro-X-ray fluorescence

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：