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Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer treatment.However,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas therapy.In this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine scaffold.Under the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation energy.We also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target mitochondria.Under an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL imaging.Collectively,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite nanogenerator Gas therapy In vivo

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Piezoelectric nanogenerator Based on Electrospun Cellulose Acetate/Nanocellulose Crystal Composite Membranes for Energy Harvesting Application

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Chemical Research in Chinese Universities 2022年第4期38卷 1005-1011页

作者： SUN Bolun CHAO Danming WANG Ce Alan G.MacDiarmid Institute Jilin UniversityChangchun130012P.R.China

nanogenerators,as the typical conversion of mechanical energy to electrical energy devices,have great potential in the application of providing sustainable energy sources for powering miniature devices.In this work,cellulose acetate/cellulose nanocrystal(CA/CNC)composite nanofiber membranes were prepared by electrospinning method and then utilized to manufacture a flexible pressure-driven nanogenerator.The addition of CNC not only increased the content of piezoelectric cellulose I crystallization but also strengthened the mechanical deformation of the nanofiber membranes,which could greatly enhance the piezoelectric performance of CA/CNC composite membranes.The CA/CNC composite nanofiber membrane with 20%(mass fraction)of CNC(CA/CNC-20%)showed optimal piezoelectric conversion performance with the output voltage of 1.2 V under the force of 5 N(frequency of 2 Hz).Furthermore,the output voltage of the CA/CNC-20%nanogenerator device exhibited a linear relationship with applied impact force,indicating the great potential in pressure sensors.

关键词： Piezoelectric nanogenerator Electrospinning Cellulose acetate Nanocellulose crystal

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nanogenerator-Based Self-Charging Energy Storage Devices

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Nano-Micro Letters 2019年第2期11卷 5-23页

作者： Kun Zhao Yuanhao Wang Lu Han Yongfei Wang Xudong Luo Zhiqiang Zhang Ya Yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou 730050People’s Republic of China Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciencesürümqi 830011XinjiangPeople’s Republic of China School of High Temperature Materials and Magnesite Resources Engineering University of Science and Technology Liaoning185 Qianshan Zhong RoadAnshan 114044People’s Republic of China School of Chemical Engineering University of Science and Technology Liaoning185 Qianshan Zhong RoadAnshan 114044People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

One significant challenge for electronic devices is that the energy storage devices are unable to provide su cient energy for continuous and long-time operation,leading to frequent recharging or inconvenient battery replacement.To satisfy the needs of next-generation electronic devices for sustainable working,conspicuous progress has been achieved regarding the development for nanogenerator-based self-charging energy storage devices.Herein,the development of the self-charging energy storage devices is summarized.Focus will be on preparation of nanomaterials for Li-ion batteries and supercapacitors,structural design of the nanogenerator-based self-charging energy storage devices,performance testing,and potential applications.Moreover,the challenges and perspectives regarding self-charging energy storage devices are also discussed.

关键词： Nanomaterial nanogenerator Energy storage device Self-charging

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Spiral Steel Wire Based Fiber-Shaped Stretchable and Tailorable Triboelectric nanogenerator for Wearable Power Source and Active Gesture Sensor

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Nano-Micro Letters 2019年第3期11卷 36-45页

作者： Lingjie Xie Xiaoping Chen Zhen Wen Yanqin Yang Jihong Shi Chen Chen Mingfa Peng Yina Liu Xuhui Sun Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon.Based Functional Materials and DevicesSoochow UniversitySuzhou215123People’s Republic of China Nantong Textile and Silk Industrial Technology Research Institute Jiangsu Industrial Technology ResearchInstitute of Textile and SilkNantong 226314People’s Republic of China Department of Mathematical Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215123People’s Republic of China

Continuous deforming always leads to the performance degradation of a flexible triboelectric nanogenerator due to the Young’s modulus mismatch of different functional layers.In this work,we fabricated a fiber-shaped stretchable and tailorable triboelectric nanogenerator(FST-TENG)based on the geometric construction of a steel wire as electrode and ingenious selection of silicone rubber as triboelectric layer.Owing to the great robustness and continuous conductivity,the FST-TENGs demonstrate high stability,stretchability,and even tailorability.For a single device with ~6 cm in length and ~3 mm in diameter,the open-circuit voltage of ~59.7 V,transferred charge of ~23.7 nC,short-circuit current of ~2.67 μA and average power of ~2.13 μW can be obtained at 2.5 Hz.By knitting several FST-TENGs to be a fabric or a bracelet,it enables to harvest human motion energy and then to drive a wearable electronic device.Finally,it can also be woven on dorsum of glove to monitor the movements of gesture,which can recognize every single finger,different bending angle,and numbers of bent finger by analyzing voltage signals.

关键词： Triboelectric nanogenerator Stretchable Human motion energy Wearable power source Active gesture sensor

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Flexible and transparent triboelectric nanogenerator based on high performance well-ordered porous PDMS dielectric film

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Nano Research 2016年第12期9卷 3714-3724页

作者： Xianming He Xiaojing Mu Quan Wen Zhiyu Wen Jun Yang Chenguo Hu Haofei Shi Department of Applied Physics Chongqing University Chongqing 400044 China Key Laboratory of Fundamental Science of Micro/Nano-Device and System Technology Chongqing University Chongqing 400044 China Microsystem Research Center Chongqing University Chongqing 400044 China Key Laboratory of Multi-Scale Manufacturing Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China

A flexible and transparent triboelectric nanogenerator （FT-TENG） has great potential for application in self-powered biosensor systems, electronic skin and wearable electronic devices. However, improving the output performance with little damage to its optical properties is challenging. Herein, we have developed an FT-TENG that has a well-ordered nest-like porous polydimethylsiloxane （NP-PDMS） film and graphene transparent electrodes. The NP-PDMS film with ordered pores is fabricated by hydrochloric acid etching of 500 nm sized ZnO spheres made of aggregated nanoparticles, having a light transmittance of 81.8% and a water contact angle of 118.62°. The FT-TENG based on the NP-PDMS film with a porosity of 12%, gives a maximum output of 271 V and 7.8 μA, which are respectively, 3.7 and 2.1-fold of those of a TENG with a flat PDMS film. The peak output power reaches 0.39 mW with a load resistance of 9.01 MΩ. The dielectric constant and effective thickness of the NP-PDMS film and the capacitance and charge transfer of the FT-TENG are systematically investigated. This work provides a novel and effective method to enhance the performance of FT-TENGs with little damage to their optical properties.

关键词： porouspolydimethylsiloxane（PDMS） surface charge density nanogenerator flexibility transparent electrode

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A flutter-effect-based triboelectric nanogenerator for breeze energy collection from arbitrary directions and self-powered wind speed sensor

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Nano Research 2019年第12期12卷 3018-3023页

作者： Jie Hu Xianjie Pu Hongmei Yang Qixuan Zeng Qian Tang Dazhi Zhang Chenguo Hu Yi Xi Department of Applied Physics State Key Laboratory of Power Transmission Equipment&System Security and New TechnologyChongqing UniversityChongqing 400044China

Triboelectric nanogenerators(TENGs)have been developed rapidly into an efficient wind energy collection equipment.Reducing the frictionwear and energy loss in breeze energy collection is a research direction worthy of attention.Herein,a flutter-effect-based triboelectricnanogen erator(FE-TENG)is designed to collect the breeze energy at low wind speed from arbitrary directions.Distinguishing from previouswind-driven TENGs,the wind-driven part of this device is separated from the TENG units,which not only avoids the wear of friction layerscaused by direct wind contact but also reduces the energy loss,therefore,relatively stable electric outputs are obtained with Voc-281 V,Isc-13.4μA,Qsc-143 nC,and output power-4 mW at the wind speed of 4.5 m/s,respectively.In addition,a real-time wind speed monitoringsystem based on LabVIEW software with high sen sitivity and fast response to wind is achieved relying on the excellent linear relation shipbetween wind speed and electrical output signal.Furthermore,it has been successfully applied as power sources for portable electronics,about 170 commercial light-emitting devices(LEDs)are lighted and a digital watch is successfully driven at the wind speed of 2.9 m/s.This worknot only provides a new structure and idea for the future collection of clean and sustainable breeze energy from arbitrary directions but also hasgreat potential in the field of self-powered systems.

关键词： flutter effect triboelectric nanogenerator arbitrary directions wind speed sensor

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All-in-one cellulose based hybrid tribo/piezoelectric nanogenerator

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Nano Research 2019年第8期12卷 1831-1835页

作者： Ming Li Yang Jie Li-Hua Shao Yilin Guo Xia Cao Ning Wang Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesNational Center for Nanoscience and Technology (NCNST)Beijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Institute of Solid Mechanics Beihang UniversityBeijing 100083China Research Center for Bioengineering and Sensing Technology Beijing Key Laboratory for Bioengineering and Sensing TechnologySchool of Chemistry and Biological Engineering Beijing Municipal Key Laboratory of New Energy Materials and Technologiesand Center for Green InnovationSchool of Mathematics and PhysicsUniversity of Science and Technology Beijing Beijing 100083China School of Materials Science and Engineering Georgia Institute of Technology AtlantaGeorgia 30332USA

Aybrid tribo/piezoelectric nanogenerators (HTPENG) have been proven to be highly efficient and versatile as far as the collection and conversion of ambient energy are concerned, and the introduction of flexible and green materials is a key step for their potential applications. Here, we developed a HTPENG by using nitrocellulose nanofibril paper as the triboelectric layer and BaTiCVMWCNT@ bacterial cellulose paper as the piezoelectric layer. The output of the triboelelctric paper has considerable performance as fluorinated ethylene propylene, and the output of piezoelectric paper is more than ten times higher than the BTO/polydimethylsiloxane structure. The integrated outputs of the sandwich structured HTPENG are 18 V and 1.6 pA·cm^-2, which are capable of lighting up three LED bulbs and charging a 1 pF capacitor to 2.5 V in 80 s. In addition, the voltage signal generated by the HTPENG in contact-separation mode can be used for dynamic pressure detection. The linear range of dynamic pressure is from 0.5 to 3 N·cm^-2 with a high sensitivity of 8.276 V·cm^-2·N^-1 and a detection limit of 0.2 N·cm^-2. This work provides new insights into the design and application of cellulose-based hybrid nanogenerators with high flexibility and simple structure.

关键词： cellulose hybrid nanogenerator energy harvesting pressure sensor

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Polymer-based nanogenerator for Biomedical Applications

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Chemical Research in Chinese Universities 2020年第1期36卷 41-54页

作者： LI Jun LONG Yin WANG Xudong Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWisconsin 53706USA

Polymeric devices are the workhorses of modern technologies.As one of the cutting-edge technology leveraging polymeric materials,nanogenerator that could convert micro-/nano-scale mechanical energy into electri-city based on the mechanism of piezoelectricity and triboelectricity exhibited great promise for biomedical applications,owning to the simple configuration,high efficiency,decent electrical output,biomimetic property as well as excellent biocompatibility.In this manuscript,the recent representative developments of NGs in biomedical applications are reviewed.Fundamentals,such as working mechanisms underneath different NG prototypes are discussed,which is followed by innovative strategies endowing NG with biomimetic mechanical properties.Intriguing attempts to implement NG in specific biomedical fields(e.g.,power source for implantable medical devices,therapeutic electric stimulator,etc.)are introduced and analyzed.This manuscript ends up with subsection summarizing existed challenges while providing potential solutions for future NG developments in biomedical engineering.

关键词： nanogenerator Polymeric material Biomedical application

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Output of an Ultrasonic Wave-Driven nanogenerator in a Confi ned Tube

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Nano Research 2009年第3期2卷 177-182页

作者： Xudong Wang Yifan Gao Yaguang Wei Zhong Lin Wang School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332-0245USA Department of Materials Science and Engineering University of Wisconsin at MadisonMadisonWisconsin 53706USA

The output of an ultrasonic wave-driven nanogenerator(NG)has been found to depend on the excitation conditions and geometry.Incidence angle tests indicate that the effective area of an NG determines the amount of power that can be generated.The output power of an NG is also directly related to its distance from the ultrasonic source.A sinusoidal profile of the electrical output was observed when an NG was moved inside a long tube filled with water with the ultrasonic source located at one end.This is due to the oscillation of the wave intensity inside the tube as a function of the distance from the excitation source.

关键词： nanogenerator ultrasonic wave ZnO nanowire

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Efficient bio-assembled nanogenerator fabricated from chicken bone epidermis

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Research and Application of Materials Science 2022年第1期4卷 24-30页

作者： Yanran MA Yongfa WANG Li LI Chunchang WANG Laboratory of Dielectric Functional Materials School of Materials Science&EngineeringAnhui UniversityHefei 230601China

Using biological self-powered materials as a new energy source to replace traditional batteries to power micro-electronic devices is a current research hotspot.We herein fabricate a piezoelectric bio-nanogenerator from chicken bones.The nanogenerator can output a voltage of 1.25 V and a current of 9 nA after being subjected to a pressure of 30 N.This research facilitates an in-depth understanding of bio-nanogenerators and provides a new strategy for reusing bio-waste.

关键词： nanogenerator collagen piezoelectric chicken bone epidermis

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