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Bioactive Materials 2022年第8期7卷 182-205页

作者： Hwa Seung Han Song Yi Koo Ki Young Choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound nanoformulation Drug delivery Phototherapy

Applications of nanomaterials in mosquito vector control:A review

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Asian Pacific Journal of Tropical Medicine 2023年第11期16卷 479-489页

作者： Sahadiya Mandodan Aneha Kunnikuruvan Bhagyashree Bora Hemaladkshmi Padmanaban Abhisubesh Vijayakumar Kakhuangailiu Gangmei Manikandan Sivaprakasam Jibi Lukose Mathivanan Ashokkumar Vijayalakshmi Krishnamoorthy Subbiah Poopathi Unit of Microbiology and Immunology ICMR-Vector Control Research CentreDepartment of Health ResearchMinistry of Health and Family WelfarePuducherry 605006India

The periodic outbreak of mosquito-borne diseases like dengue fever,zika fever,and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological *** to the lack of therapeutic measures,preventive treatments or vaccines against pathogens,insecticide resistance eventually lead the research focus towards novel technological applications in mosquito *** with ovicidal,larvicidal,adulticidal,and repellent properties for controlling mosquito vectors are under research.A literature search was carried out for advancements in nanomaterials,insecticides,and mosquito control in PubMed/MEDLINE,Scopus,Google Scholar,ScienceDirect,and Web of *** paper aims to provide insights into various nanomaterials relevant to mosquito-borne diseases,in vivo and in vitro toxicity evaluation against mosquito species,mode of action,effect on non-target organisms,and ecological *** and inorganic materials that provide controlled release,target delivery,less dosage,prolonged efficacy,a reduction in the use of organic solvents and emulsifiers,and minimum pollution to the environment have already been ***,further research on the ecological risk and economic feasibility of nanomaterials in mosquitocidal applications should be done prior to commercialization.

关键词： Nanomaterials nanoformulation Nanopesticides Mosquito control

Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation

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Chinese Chemical Letters 2024年第10期35卷 39-52页

作者： Keyang Li Yanan Wang Yatao Xu Guohua Shi Sixian Wei Xue Zhang Baomei Zhang Qiang Jia Huanhua Xu Liangmin Yu Jun Wu Zhiyu He Frontiers Science Center for Deep Ocean Multispheres and Earth Systems Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of Education/Sanya Oceanographic InstitutionOcean University of ChinaQingdao/Sanya 266100/572024China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266003China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Guangzhou City Polytechnic Guangzhou 510520China National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine Jiangxi University of Chinese MedicineNanchang330004China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SAR 999077China

The application of nanotechnologies in formulation has significantly promoted the development of modern medical and pharmacological science, especially for nanoparticle-based drug delivery, bioimaging, and theranostics. The advancement of engineering particle design and fabrication is largely supported by a better understanding of how their apparent characteristics(e.g., size and size distribution, surface morphology, colloidal stability, chemical composition) influence their in vivo biological performance, which raises an urgent need for practical nanoformulation methods. Based on turbulent flow mixing and the self-assembly of molecules in fluids, flash technologies emerged as effective bottom-up fabrication strategies for effective nanoformulation. Among the flash technology family, flash nanocomplexation(FNC) is considered a novel and promising candidate that can promote and optimize formulation processes in a precise spatiotemporal manner, thus obtaining excellent fabrication efficiency, reproducibility and expandability. This review presents an overview of recent advances in fabricating drug-delivery nanoparticles using FNC platforms. Firstly, brief introductions to the basic principles of FNC technology were carried out, followed by descriptions of turbulent microvolume mixers that have significantly promoted the efficiency of FNC-based fabrications. Applications of real formulation cases were then categorized according to the self-assembly-driven interactions(including electrostatic interaction, coordination interaction,hydrogen bonding and hydrophobic interaction) and discussed to reveal the progressiveness of fabricating nanoparticles and discuss how its flexibility will provide advances and replenish the philosophy of nanomedicine formulation. In the end, the commercial potential, current limitations, and prospects of FNC technology for nanoformulation will be summarized and discussed.

关键词： nanoformulation Nanoparticles Self-assembly Flash nanocomplexation Kinetic control Drug delivery

Nanotechnological approaches in diabetes treatment: A new horizon

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World Journal of Translational Medicine 2014年第2期3卷 84-95页

作者： Asmita Samadder Anisur Rahman Khuda-Bukhsh Cytogenetics and Molecular Biology Laboratory Department of Zoology University of Kalyani

Diabetes is a chronic metabolic disorder that affects millions of people worldwide and takes a heavy toll on human life. Treatment of diabetics often poses a problem in selection of the proper drug, its dose and unwanted side effects. Therefore, newer drugs with the least side effects but with highest efficiency are being relentlessly searched for. In recent years, nanotechnology has given new hope for the formulation of various drugs against a myriad of diseases, including diabetes. This review tries to give an overview of the advantages of various new drugs being used, including a wide range of nanoformulations of orthodox as well complementary and alternative medicines. Several studies and research reports based on nanotechnological approaches in the formulation of anti-diabetic drugs have pointed out the fact that research in the formulation of nanodrugs improved strategies for combating diabetes based on the plausible molecular mechanism of action of the drugs. Furthermore, attempts have also been made to delineate the optimum drug concentration and time of exposure in order to recommend a scientifically validated drug dose response in developing different therapeutic strategies. Thus, to a considerable extent, recent studies have contributed towards improving thelife expectancy and quality of life of diabetics, through both targeted orthodox medicine and complementary medicine, particularly those obtained from natural resources.

关键词： Diabetes Complementary and orthodox medicine(s) Orthodox anti-diabetic medicines Nanotechnology and nanomedicine nanoformulation

The Interesting of Antifungal Effects of Novel In Vitro Fabrics of Stabilized ZnO Nanofluids

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Advances in Nanoparticles 2016年第4期5卷 206-223页

作者： Fatemeh Katouzian Zahra Fakhroueian Soheila Moradi Bidhendi Department of Microbiology Faculty of Advanced Sciences and Technology Pharmaceutical Sciences (IAUPS) Tehran Iran School of Chemical Engineering College of Engineering and IPE University of Tehran Tehran Iran Microbiology Department Razi Vaccine and Serum Research Institute Karaj Iran

According to the extent of fungal infections, to be chronic these such diseases and recently the emerging issue of increased antibiotic resistance in fungal infections, most of scientists are going to find a proper way to replace antibacterial agent by significant semiconductor ZnO nanoparticles (NPs). They are well known to be one of the most important and special metal oxide nanoparticles in pharmaceutical against the most common fungi. ZnO nanoparticles were synthesized using sol-gel, hydrothermal and functionalized surface methods and formulated in water solutions as nanofluids. XRD, FTIR and SEM techniques and UV-Vis absorbance spectroscopy characterized their ZnO modified nanostructures. Also antimycotic potential according to generally tests such as: (MIC) minimum inhibitory concentration, (MFC) minimum fungicidal concentration and normally well diffusion method with standard strains fungi were performed. Among five common fungi strains using in this research, new various ZnO nanofluids showed noticeable results for dermatophyte fungi like Trichophyton mentagrophytes, Microsporum gypseum, Microsporum canis, Candida albicans and Candid tropicalis which had un growth zones in order 70, 40, 35, 30 and 30 mm in comparing with Clotrimazole reference reagent: 30, 25, 25, 18 and 20 mm by well method. The performance of MIC for ZnO nanofluids on fungi was determined to be equal to 0.35, 3.12, 6.25, 6.25 and 6.25 μgr/ml and MFC of nanoproducts showed the 1.5, 12.5, 25, 25 and 25 μgr/ml. Therefore, the designed ZnO nanofluids could reveal the most effect on fungi which cause dermal (ringworm), mucosal (thrush) and vaginal infections, so we are able to apply these surface high energetic ZnO water-based nanofluid formulations as in vitro nanomedicine and nanohygiene for the first time.

关键词： ZnO Nanofluids Potential Medical Applications Antifungal Activity Traditional Re-sistant Antibiotic Surface Modification Nanomedicine Nanohygiene MFC nanoformulation Stabilized Water-Based Nanoparticle