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Unleashing the healing potential:Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery

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Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 100-112页

作者： Liangwei Si Xiong Guo Hriday Bera Yang Chen Fangfang Xiu Peixin Liu Chunwei Zhao Yasir Faraz Abbasi Xing Tang Vito Foderà Dongmei Cun Mingshi Yang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Dr.B.C.Roy College of Pharmacy and Allied Health Sciences Durgapur 713206India Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacy Faculty of Health and Medical SciencesUniversity of Copenhagenniversitetsparken 2DK-2100 Copenhagen ODenmark

Burn injury is a serious public health problem and scientists are continuously aiming to develop promising biomimetic dressings for effective burn wound *** this study,a greater efficacy in burn wound healing and the associated mechanisms ofα-lactalbumin(ALA)based electrospun nanofibrous scaffolds(ENs)as compared to other regenerative protein scaffolds were *** serum albumin(BSA),collagen type I(COL),lysozyme(LZM)and ALA were separately blended with poly(ε-caprolactone)(PCL)to fabricate four different composite ENs(LZM/PCL,BSA/PCL,COL/PCL and ALA/PCL ENs).The hydrophilic composite scaffolds exhibited an enhancedwettability and variablemechanical *** ALA/PCL ENs demonstrated higher levels of fibroblast proliferation and adhesion than the other composite *** compared to PCL ENs and other composite scaffolds,the ALA/PCL ENs also promoted a better maturity of the regenerative skin tissues and showed a comparable wound healing effect to Collagen sponge^(■)on third-degree burn *** enhanced wound healing activity of ALA/PCL ENs compared to other ENs could be attributed to their ability to promote serotonin production at wound ***,this investigation demonstrated that ALA is a unique protein with a greater potential for burn wound healing as compared to other regenerative proteins when loaded in the nanofibrous scaffolds.

关键词： Regenerative proteins α-lactalbumin Serotonin Electrospinning nanofibrous dressing Third-degree burn

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