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Diffusion of lanthanum in nanocrystallized surface layer during plasma rare earth nitriding of 3J33B steel

中国有色金属学会会刊：英文版 2005年第S2期15卷 293-296页

作者：闫牧夫 School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

Plasma rare earth nitriding of nanocrystallized surface layer of 3J33B steel at 350 and 410℃ for different time was studied. The microstructure observation and X-ray diffraction（XRD） analysis show that the nitriding layer consists of compound layer （γ′-Fe4N） and diffusion layer （α-Fe）. Lanthanum content profiles in nanocrystallized surface layer were measured using glow discharge spectometry（GDS）. The results show that lanthanum can diffuse into the surface layer of the steel to a large depth. Based on the experimental results mentioned above, the diffusion coefficients and activation energy of lanthanum in γ′ phase are calculated to be 1.03×10 -15 cm2/s （350℃）, 1.75×10 -15 cm2/s （410℃） and 31.313kJ/mol, respectively.

关键词： 3J33 steel nanocrystallized surface layer plasma nitriding lanthanum diffusion

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The Research of nanocrystallized Realgar for the Treatment of Skin Cancer

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Journal of Cancer Therapy 2013年第6期4卷 43-47页

作者： Yuanfu Qi Xiurong Li Huijie Li Yi Zheng The Department of Oncology of the Affiliated Hospital of Shandong University of TCM Jinan City China

Objective: To observe the effects and mechanisms of nanocrystallized realgar for the treatment of skin cancer. Methods: The clinical part was observing the therapeutic effect for the skin ulceration by externally using the nanocrystallized realgar. The experimental part was culturing the human squamous cell carcinoma A431 cells (A431) in vitro environment, estimating the effects of proliferation and apoptosis of A431 by MTT method and flow cytometry, and observing the effects on the expression of Survivin, Caspase-3 by RT-PCR method. Results: External treatment with nanocrystallized realgar had a therapeutic effect for the skin ulceration;it can promote the ulcers of skin cancer and skin metastasis healing. The experiments confirmed that nanocrystallized realgar can inhibit the A431 proliferation, induce the cells apoptosis, promote the expression of Caspase-3 and reduce the expression of Survivin. And the experiments also found that the effects were in a concentration-dependent manner, and they have a synergistic effect with cis-Dichlorodiamineplatinum (DDP). Conclusions: External treatment with nanocrystallized realgar for the patients of skin cancer or skin metastasis achieved satisfactory therapeutic effects by inhibiting A431 proliferation and inducing these cells apoptosis. The mechanism might be associated with promoting the expression of Caspase-3 and reducing the expression of Survivin.

关键词： Skin Cancer nanocrystallized Realgar Ulceration Inhibition of Proliferation Induction of Apoptosis

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