检索结果-南通市图书馆

Ultrasmall copper-based clusterzymes ameliorate Achilles tendinopathy by inhibiting acute oxidative stress

Nano Research 2024年第6期17卷 5374-5389页

作者： Xuzhuo Chen Yi Du Yazi Huang Xianhao Zhou Xinru Xie Chang Li Chen Zhao Fengrong Dai Xijiao Yu Shanyong Zhang Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China Department of Endodontics Central LaboratoryJinan Stomatological HospitalJinan Key Laboratory of Oral Tissue RegenerationShandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue RegenerationJinan 250001China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Department of Chemistry College of Chemistry and EnvironmentGuangdong Ocean UniversityZhanjiang 524088China Department of Orthopedics Shanghai Key Laboratory of Orthopedic ImplantShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Tendinopathy is a prevalent musculoskeletal disorder,accounting for over 30%of musculoskeletal lesions.However,current therapeutic strategies for tendinopathy are limited and often yield unsatisfactory clinical outcomes.Therefore,there is a critical need to explore novel therapeutic approaches with minimal side effects for tendinopathy and its early lesions.In this study,we successfully designed and synthesized a copper(I)-based nanocluster,named Cu_(11),which possesses remarkable enzyme-like and ROS-scavenging activities.This unique combination of properties qualifies Cu_(11)as an attractive anti-inflammatory and anti-ROS agent.The Cu_(11)clusterzymes specifically target mitochondria,effectively scavenging excessive reactive oxygen species(ROS)and reducing oxidative stress.Furthermore,Cu_(11)clusterzymes inhibit the activation of key signaling pathways involved in inflammation,namely tumor necrosis factor(TNF),mitogen-activated protein kinase(MAPK),and nuclear factor(NF)-κB,leading to a decrease in the release of proinflammatory cytokines.Excitingly,our in vivo experiments using a collagenase-induced acute Achilles tendinopathy model demonstrated that Cu_(11)clusterzymes effectively alleviate inflammation and oxidative stress,without causing systemic toxicity.This study highlights the potential of copper-based clusterzymes as therapeutic agents for the treatment of Achilles tendinopathy and other inflammatory diseases.The unique enzyme-like and ROS-scavenging activities of Cu_(11)make it a promising candidate for further development and clinical translation.

关键词： nanoclusters clusterzymes oxidative stress tendinopathy reactive oxygen species(ROS)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrasmall AuPd nanoclusters on amine-functionalized carbon blacks as high-performance bi-functional catalysts for ethanol electrooxidation and formic acid dehydrogenation

引用

Journal of Energy Chemistry 2022年第5期31卷 556-563页

作者： Yuhuan Cui Ming Zhao Yining Zou Junyu Zhang Jiuhui Han Zhili Wang Qing Jiang Key Laboratory of Automobile Materials Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022JilinChina Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversitySendai 980-8578Japan

The synthesis of ultrasmall metal nanoclusters(NCs) with high catalytic activities is of great importance for the development of clean and renewable energy technologies but remains a challenge. Here we report a facile wet-chemical method to prepare ~1.0 nm Au Pd NCs supported on amine-functionalized carbon blacks. The Au Pd NCs exhibit a specific activity of 5.98 mA cm_(AuPd)^(-2)and mass activity of 5.25 A mg_(auPd)^(-1) for ethanol electrooxidation, which are far better than those of commercial Pd/C catalysts(1.74 mAcm_(AuPd)^(-2) and 0.54 A mg_(Pd)^(-1) ). For formic acid dehydrogenation, the Au Pd NCs have an initial turn over frequency of 49339 h^(-1) at 298 K without any additive, which is much higher than those obtained for most of reported Au Pd catalysts. The reported synthesis may represent a facile and low-cost approach to prepare other ultrasmall metal NCs with high catalytic activities for various applications.

关键词： Ethanol electrooxidation Formic acid dehydrogenation AuPd nanoclusters Bi-functional catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tailoring optical and photocatalytic properties by single-Ag-atom exchange in Au_(13)Ag_(12)(PPh_(3))_(10)C_(l8) nanoclusters

引用

Nano Research 2022年第4期15卷 2971-2976页

作者： Zhaoxian Qin Song Hu Wenhua Han Zhiwen Li Wen Wu Xu Jingjing Zhang Gao Li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Physics School of Physical Science and TechnologyNingbo UniversityNingbo 315211China CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Precise mono-doping of metal atom into metal particles at a specific particle position(e.g.,the central site)in a highly controllable manner is still a challenge.In this work,we develop a highly controllable strategy for exchanging a single Ag atom into the central gold site of Au_(13)Ag_(12)(PPh_(3))_(10)C_(l8)(Ph=phenyl)nanoclusters.Interestingly,a“pigeon-pair”cluster of{[Au_(13)Ag_(12)(PPh_(3))_(10)C_(l8)]·[Au_(12)Ag_(13)(PPh_(3))_(10)C_(l8)]}^(2+)is obtained and confirmed by electrospray ionization mass spectrometry(ESI-MS),thermogravimetric analysis(TGA)and single crystal X-ray diffraction(SCXRD)analysis.The experimental results and density functional theory(DFT)calculations suggest that the single-metal-atom exchanging from[Au_(13)Ag_(12)(PPh_(3))_(10)C_(l8)]^(+)to[Au_(12)Ag_(13)(PPh_(3))_(10)C_(l8)]^(+)occurs at the central position through the side entry of theμ_(3)-bridging Cl atoms.Finally,the effects on the electronic structure and properties caused by the single-atom exchange at the central site are shown by the enhancement of fluorescence and catalytic activity in the photocatalytic oxidation of ethanol.

关键词： single atom exchange nanoclusters photoluminescence enhancement photocatalyst of ethanol alloy clusters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light-guided tumor diagnosis and therapeutics:From nanoclusters to polyoxometalates

引用

Chinese Chemical Letters 2022年第6期33卷 2783-2798页

作者： Xiaofeng Fan Wei Pang Hao Feng Ruiyi Zhang Wentao Zhu Qiushi Wang Jun Miao Yiwen Li Yanjun Liu Xiaoqian Xu Key Laboratory of Cell Biology Ministry of Public Health and Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyang 110122China Guangdong Provincial Key Laboratory of Catalysis Shenzhen Grubbs Institute and Department of ChemistrySouthern University of Science and Technology.Shenzhen 518000China School of Materials Science and Engineering Hubei UniversityWuhan 430062China Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518000China Department of Ophthalmology The First Affiliated Hospital of China Medical UniversityShenyang 110001China

Malignant tumors,with the characteristics of easy metastasis and recurrence,are a serious threat to health of mankind.It is urgent to develop promising clinical cancer targeted agents with combination of rapid diagnosis and efficient therapies.Compared with the conventional photosensitizing agents,the recent advances of nanoagents based on transition metal-oxide clusters possess unique structural and electronic properties,greatly improving cancer survival rate,meanwhile,keeping high contrast imaging.This review provides a brief introduction of metal-oxide clusters,including both nanoclusters to molecular clusters,specifically polyoxometalates(POMs).Subsequently,biocompatibility of metal-oxide clusters is emphasized from aspects of endocytosis,macropinocytosis,and phagocytosis.Through the classification of late and early transition metals oxide clusters,recent outcomes of light-guided nanoagents are represented with their intriguing chemical and optical properties in their diagnosing and photochemotherapy performance.It shed light on the summary of next generation multifunctional cancer targeting agents'developments as well as outlook of materials selection trends and research direction in the future.

关键词： Polyoxometalates Light-guided nanoagents nanoclusters Metal oxides clusters Photothermal therapy Photodynamic therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Size Effects of Atomically Precise Gold nanoclusters in Catalysis

Precision Chemistry

引用

Precision Chemistry 2023年第1期1卷 14-28页

作者： Site Li Xiangsha Du Zhongyu Liu Yingwei Li Yucai Shao Rongchao Jin Department of Chemistry Carnegie Mellon UniversityPittsburghPennsylvania 15213United States

The emergence of ligand-protected,atomically precise gold nanoclusters(NCs)in recent years has attracted broad interest in catalysis due to their well-defined atomic structures and intriguing properties.Especially,the precise formulas of NCs provide an opportunity to study the size effects at the atomic level without complications by the polydispersity in conventional nanoparticles that obscures the relationship between the size/structure and properties.Herein,we summarize the catalytic size effects of atomically precise,thioate-protected gold NCs in the range of tens to hundreds of metal atoms.The catalytic reactions include electrochemical catalysis,photocatalysis,and thermocatalysis.With the precise sizes and structures,the fundamentals underlying the size effects are analyzed,such as the surface area,electronic properties,and active sites.In the catalytic reactions,one or more factors may exert catalytic effects simultaneously,hence leading to different catalytic-activity trends with the size change of NCs.The summary of literature work disentangles the underlying fundamental mechanisms and provides insights into the size effects.Future studies will lead to further understanding of the size effects and shed light on the catalytic active sites and ultimately promote catalyst design at the atomic level.

关键词： atomic precision nanoclusters catalysis size effects electronic structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solvent-induced reversible transformation between monomer-Ag_(32) and dimer-(Ag_(32))_(2) nanoclusters

引用

Chinese Journal of Structural Chemistry 2023年第7期42卷 28-33页

作者： Ying Xu Hao Li Jiaojiao Han Xuejuan Zou Xi Kang Manzhou Zhu Department of Chemistry and Centre for Atomic Engineering of Advanced Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized MaterialsAnhui UniversityHefei230601China

The controllable transformation of metal nanoclusters remains highly desirable for the preparation of new clusters with novel structures and the elucidation of cluster conversion mechanisms.Here,we present the reversible transformation between two high-nuclearity silver cluster homologs,Ag_(32)S_(3)(S^(t)Bu)_(16)(CF_(3)COO)_(9)(CH_(3)CN)_(4)(NO_(3))(abbreviated as monomer-Ag_(32))and[Ag_(32)S_(3)(S^(t)Bu)_(16)(CF_(3)COO)_(9)(CH_(3)CN)(NO_(3))]_(2)(abbreviated as dimer-(Ag_(32))_(2)).Triggered by the solvent effect,the reversible conversion between monomer-Ag_(32) and dimer-(Ag_(32))_(2) nanoclusters has been accomplished.For dimer-(Ag_(32))_(2),two CF_(3)COO-linkers were bound onto the symmetrical edges of adjacent Ag_(32) subunits,giving rise to the dimeric existence form of the final cluster.The optical properties,including optical absorptions and emissions,of the cluster monomer and dimer were then compared.This work offered an interesting case for constructing self-assembled cluster structures with the assistance of certain solvents and multidentate ligands.

关键词： nanoclusters Structure determination Reversible transformation Self-assembly Structure-property correlations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atomically precise metal-chalcogenide semiconductor molecular nanoclusters with high dispersibility:Designed synthesis and intracluster photocarrier dynamics

引用

Nano Research 2020年第10期13卷 2828-2836页

作者： Jiaxu Zhang Chaochao Qin Yeshuang Zhong Xiang Wang Wei Wang Dandan Hu Xiaoshuang Liu Chaozhuang Xue Rui Zhou Lei Shen Yinglin Song Dingguo Xu Zhien Lin Jun Guo Haifeng Su Dong-Sheng Li Tao Wu College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Henan Key Laboratory of Infrared Materials&Spectrum Measures and Applications School of PhysicsHenan Normal UniversitXinxiang 453007China College of Chemistry Sichuan UnivrsityChengdu 610064China School of Physical Science and Technology Soochow UniversitySuzhou 215123China Testing&Analysis Centre Soochow UniversitySuzhou 215123China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China College of Materials and Chemical Engineering Hubei Provincial Collaborative Innovation Centre for New Energy Microgrid Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China

A comprehensive understanding of excited-state dynamics of semiconductor quantum dots or nanomaterials at the atomic or molecular level is of scientific importance.Pure inorganic(or non-covalently protected)seimiconductor molecular nanoclusters with atomically precise structure are contributive to establish accurate correlation of excited-state dynamics with their composition/structure,however,the related studies are almost blank because of unresolved solvent dispersion issue.Herein,we designedly created the largest discrete chalcogenide seimiconductor molecular nanoclusters(denoted P2-CuMSnS,M=In or/and Ga)with great dispersibility,and revealed an interesting intracluster“core–shell”charge transfer relaxation dynamics.A systematic red shift in absorption spectra with the gradual substitution of In by Ga was experimentally and computationally investigated,and femtosecond transient absorption measurements further manifested there were three ultrafast processes in excited-state dynamics of P2 nanoclusters with the corresponding amplitudes directed by composition variation.Current results hold the great promise of the solution-processible applications of semiconductor-NC-based quantum dots and facilitate the development of atomically precise nano-chemistry.

关键词： semiconductor nanoclusters photocarrier dynamics charge transfer atomically precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Luminescent metal nanoclusters for biomedical applications

引用

Nano Research 2019年第6期12卷 1251-1265页

作者： Yu Su Tiantian Xue Yuxin Liu Jinxia Qi Rongchao Jin Zhenkun Lin Center of Scientific Research The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325035China Department of Chemistry Carnegie Mellon UniversityPittsburghPA 15213USA

Luminescent metal nanoclusters (NCs) have recently emerged as a novel class of luminescent nanomaterials and hold significant potential in biomedicine owing to their ultrasmall (<2nm) size,excellent photostability,and good biocompatibility.The recent rapid advances in the synthesis and functionalization of luminescent metal NCs have enabled scientists to develop colorful nanomaterials and nanodevices for a wide range of biomedical applications.In this review,we summarize the characteristics and advantages of luminescence from metal NCs,and highlight their applications in biomedicine.We focus on the research in biomedical detection,bio-imaging,drug delivery,and therapy,especially for the advances in the last five years.Luminescent metal NCs display a series of unique superiorities in biomedical applications,and the recent achievements have brought a lot of benefits to the diagnosis and treatment of clinical diseases,especially for tumors and cancers.Finally,we put forward the main challenges that currently still hinder the basic science studies and the practical development of luminescent metal NCs in biomedical applications.Overall,we expect that luminescent metal NCs will play a much more important role in future biomedicine and clinical applications.

关键词： metal nanoclusters luminescence biomedicine biomedical detection bio-imaging drug delivery therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ag7(MBISA)6 nanoclusters Conjugated with Quinacrine for FRET-Enhanced Photodynamic Activity under Visible Light Irradiation

引用

物理化学学报 2018年第7期34卷 805-811页

作者： TOMINAGA Chiaki HIKOSOU Dailo OSAKA Issey KAWASAK Hideya Department of Chemistry and Materials Engineering Faculty of Chemistry Materials and Bioengineering Kansai University Suita-shi Osaka 564-8680 Japan Center for Nano Materials and Technology Advanced Institute of Science and Technology 1-1 A

Singlet oxygen(1 O2) plays an important role in various applications, such as in the photodynamic therapy(PDT) of cancers,photodynamic inactivation of microorganisms, photo-degradation of toxic compounds, and photo-oxidation in synthetic chemistry. Recently,water-soluble metal nanoclusters(NCs) have been utilized as photosensitizers for the generation of highly reactive 1 O2 because of their high water solubility, low toxicity, and surface functionalizability for targeted substances. In the case of metal NC-based photosensitizers, the photo-physical properties depend on the core size of the NCs and the core/ligand interfacial structures. A wide range of atomically precise gold NCs have been reported; however, reports on the synthesis of atomically precise silver NCs are limited due to the high reactivity and low photostability(i.e., easy oxidation) of Ag NCs. In addition, there have been few reports on what kinds of metal NCs can generate large amounts of 1 O2. In this study, we developed a new one-pot synthesis method of water-soluble Ag7(MBISA)6(MBISA= 2-mercapto-5-benzimidazolesulfonic acid sodium salt) NCs with highly efficient 1 O2 generation ability under the irradiation of white light emitting diodes(LEDs). The molecular formula and purity were determined by electrospray ionization mass spectrometry and gel electrophoresis. To the best of our knowledge, this is the first report on atomically precise thiolate silver clusters(Agn(SR)m) for efficient 1 O2 generation under visible light irradiation. The 1 O2 generation efficiency of Ag7(MBISA)6 NCs was higher than those of the following known water-soluble metal NCs: bovine serum albumin(BSA)-Au25 NCs,BSA-Ag8 NCs, BSA-Ag14 NCs,Ag25(dihydrolipoic acid)14 NCs,Ag35(glutathione)18 NCs,and Ag75(glutathione)40 NCs. The metal NCs examined in this study showed the following order of 1 O2 generation efficiency under white light irradiation: Ag7(MBISA)6 > BSA-Ag14 > Ag75(SG)40 > Ag35(SG)18 >BSA-Au25 >>BSA-Ags(not detected) and Ag2 s(DHLA)14(not detected). For further im

关键词： Silver nanoclusters Singlet oxygen Photodynamic therapy Organic dyes FRET Hybrid photosensitizers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrocatalytic and photocatalytic applications of atomically precise gold-based nanoclusters

引用

Science China Chemistry 2021年第7期64卷 1065-1075页

作者： Yongnan Sun Xiao Cai Weigang Hu Xu Liu Yan Zhu School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China

With advances in cluster chemistry,atomically precise gold nanoclusters(NCs)with well-defined composition and tunable structure provide an exciting opportunity to uncover the specific roles of the geometrical and electronic structures as well as the capped ligands in overall catalytic performances.The Au NCs possess quantum energy levels and unique optical properties,which have exhibited unexpected photocatalytic and electrocatalytic activities.In this review,we first highlight the electrocatalytic applications of Au NCs,including hydrogen evolution reaction,oxygen reduction reaction,CO_2 reduction and catalytic oxidation reactions,and then present Au NCs-driven photocatalytic applications such as selective organic reactions,decomposition of pollutants and energy conversion reactions.Finally,we conclude this review with a brief perspective on the catalytic field of Au NCs.

关键词： nanoclusters atomic-level structure electronic structure electrocatalysis photocatalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：