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Molecular study of HCV detection,genotypes and their routes of transmission in North West Frontier Province,Pakistan

引用

Asian Pacific Journal of Tropical Biomedicine 2012年第7期2卷 532-536页

作者： Asher Zaman Safi Yasir Waheed Joharia Sadat Solat-Ul-Islam Sadia Salahuddin Umar Saeed Muhammad Ashraf Atta-ur-Rahman School of Applied Biosciences(ASAR) National University of Science and Technology(NUST) Lady Reading Hospital(L.R.H)Peshawar

Objective:To determine hepatitis C virus(HCV) genotypes and explore the associated risk factors in chronic HCY ***:A total of 116 patients with chronic hepatitis C were subjected to polymerase chain reaction(PCR) based detection out of which 112 chronic HCV patients[53 male(47.32%),59 female(52.68%);mean age(43.76±16.40) years;mean BMI(23.8± 3.9)kg]were enrolled in this *** frequency of 6 HCV genotypes and associated risk factors were evaluated from five districts of North West Frontier Province(nwfp).Results:Genotype 3was the most prevalent in 73 samples(65.17%) followed by genotype 1 in 24(21.42%) and genotype2 in 13(11.60%) ***3 had significantly high prevalence(P=0.0002).The results showed that 48(42.85%) samples were infected with HCV 3a:25(22.32%) with 3b;14(12.50%) with 1a;10(8.92%)with 1b;11(9.82%) with 2a;2(1.78%) with 2b;and 2 were *** distribution of HCV genotypes in ***,*** and Nowshehra districts was *** of unsterile equipment lor medication,barbers and previous history of hospitalization were the main risk factors for HCV ***:Cenotype 3a and 3b.1a.1b and 2a are the common genotypes in *** *** 6 can not be found in a single *** level of awareness about various modes ot transmission of HCV among the population is found to be verv low.

关键词： HCV Genotypes Subtype 3a Risk factors nwfp Transmission Molecular study PCR

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