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nod-like receptors in the development of intestinal inflammation and cancer

赣南医学院学报 2015年第4期35卷 497-502页

作者： CHEN Ya-yun CHEN Mei-hua HE Liang-mei ZHENG Rong LIU Yang-bin LIU Zhi-ping School of Basic Medicine Gannan Medical University School of Clinical Medicine Gannan Medical University

Introduction Inflammatory bowel diseases(IBD),such as Crohn’s disease(CD)and ulcerative colitis(UC),are a group of chronic inflammatory disorders of the gastrointestinal tract[1-2].The symptoms of IBD include abdominal pain,diarrhea,and bloody stool.IBD affects a patient’s quality of life severely,due in part to its frequent recurrence.Colorectal cancer(CRC)is a malignancy in the colon or rectum with symptoms including bloody stool,changes in

关键词： nod-like receptors Inflammasome Colitis Colorectal cancer

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Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

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Cellular & Molecular Immunology 2017年第1期14卷 80-89页

作者： Yajuan Li Yuelong Li Xiaocong Cao Xiangyu Jin Tengchuan Jin Laboratory of Structural Immunology CAS Key Laboratory of Innate Immunity and Chronic Disease CAS Center for Excellence in Molecular Cell Science School of Life Sciences and Medical Center University of Science and Technology of China Hefei Anhui 230027 China

Pattern recognition receptors （PRRs） and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.

关键词： caspases innate immune system nod-like receptors pattern recognition receptor RIG-I-like receptors Toll-like receptors zebrafish

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Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation

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Protein & Cell 2012年第2期3卷 98-105页

作者： Yi-Nan Gong Feng Shao National Institute of Biological Sciences Beijing 102206China Howard Hughes Medical Institute National Institute of Biological SciencesBeijing 102206China

The inflammasome is an emerging new pathway in innate immune defense against microbial infection or endogenous danger signals.The inflammasome stimulates activation of inflammatory caspases,mainly caspase-1.Caspase-1 activation is responsible for processing and secretion of IL-1βand IL-18 as well as for inducing macrophage pyroptotic death.Assembly of the large cytoplasmic inflammasome complex is thought to be mediated by members of nod-like receptor(NLR)family.While functions of most of the NLR proteins remain to be defined,several NLR proteins including NLRC4 have been shown to assemble distinct inflammasome complexes.These inflammasome pathways,particularly the NLRC4 inflammasome,play a critical role in sensing and restricting diverse types of bacterial infections.Here we review recent advances in defining the exact bacterial ligands and the ligand-binding receptors involved in NLRC4 inflammasome activation.Implications of the discovery of the NAIP family of inflammasome receptors for bacterial flagellin and type III secretion apparatus on future inflammasome and bacterial infection studies are also discussed.

关键词： inflammasome nod-like receptors NLRC4 caspase-1 NAIP type III secretion system flagellin Salmonella Legionella enteropathogenic E.coli Burkholderia

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