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Novel phenanthrene/bibenzyl trimers from the tubers of Bletilla striata attenuate neuroinﬂammation via inhibition of NF-κB signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 441-454页

作者： SHAO Siyuan SUN Mohan MA Xianjie JIANG Jianwei TIAN Jinying ZHANG Jianjun YE Fei LI Shuai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla striata.Their structures were elucidated through comprehensive analyses of NMR and HRESIMS spectroscopic data.The absolute configurations of these compounds were determined by calculating rotational energy barriers and comparison of experimental and calculated ECD curves.Compounds 5b and 6 exhibited inhibitory effects on LPS-induced NO production in BV-2 cells,with IC_(50) values of 12.59±0.40 and 15.59±0.83μmol·L^(-1),respectively.A mechanistic study suggested that these compounds may attenuate neuroinflammation by reducing the activation of the AKT/IκB/NF-κB signaling pathway.Additionally,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) values of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol·L^(-1),respectively.Further investigation revealed that compound 3a might inhibit LPS-induced PTP1B overexpression and NF-κB activation,thereby mitigating the neuroinflammatory response in BV-2 cells.

关键词： Bletilla striata Phenanthrene/bibenzyl trimer no inhibition AKT/IκB/NF-κB signaling pathway PTP1B inhibitory effect

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New tirucallane-type triterpenoids from the resin of Boswellia carterii and their NO inhibitory activities

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Chinese Journal of Natural Medicines 2021年第9期19卷 686-692页

作者： LIU Fang-Shen ZHANG Ting-Ting XU Jun JING Qin-Xue GONG Chi DONG Bang-Jian LI Da-Hong LIU Xiao-Qiu LI Zhan-Lin YUAN Zhong HUA Hui-Ming Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Medicinal Chemical Biology College of Pharmacyand Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300071China

Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chloride extract of the resin of Boswellia carterii Birdw.By the application of the comprehensive spectroscopic data,the structures of the compounds were clarified.The experimental electronic circular dichroism spectra were compared with those calculated,which allowed to assign the absolute configurations.Compounds 5 and 6 possesed a 2,3-seco tirucallane-type triterpenoid skeleton,which were first reported.Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated.Compound 9 showed appreciable inhibitory effect,with an IC_(50)value of 7.58±0.87μmol·L^(-1).

关键词： Boswellia carterii Birdw seco-Tirucallane triterpenoids no inhibition

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Lignans with NO inhibitory activity from Tinospora sinensis

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Chinese Journal of Natural Medicines 2021年第7期19卷 500-504页

作者： ZHANG Jun-Sheng XU De-Feng CAO Xin-Xin WANG Yin-Yin ZHANG Hua School of Biological Science and Technology University of JinanJinan 250022China

Two new lignan glucosides,tinsinlignans A and B(1 and 2),two new oxyneolignans,tinsinlignans C and D(3 and 4),along with one known analogue(5),were isolated from the stems of Tinospora sinensis.The structures of the new compounds were elucidated based on analysis of spectroscopic data,and the absolute configuration of 1 was determined through electronic circular dichroism(ECD)calculation based on the time-dependent density functional theory(TD-DFT).Compounds 1−4 were evaluated for their inhibitory effects on nitric oxide(NO)production induced by lipopolysaccharide(LPS)in murine RAW264.7 macrophage cells and compounds 1 and 2 exhibited moderate inhibitory activities with IC50 values of 18.5±2.0 and 28.8±1.2μmol·L^(−1),respectively.

关键词： Tinospora sinensis Lignan glucoside Oxyneolignan ECD calculation no inhibition

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Harvesting Age and Time Effect of Andrographis paniculata Leaf on Its Anti-Inflammatory Activity

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Journal of Biosciences and Medicines 2016年第12期4卷 175-188页

作者： Azizul Isha Nur A’thifah Yusof Intan Safinar Ismail Laboratory of Natural Products Institute of Bioscience Universiti Putra Malaysia Serdang Malaysia Department of Chemistry Faculty of Science Universiti Putra Malaysia Serdang Selangor Darul Ehsan Malaysia

In this study, Fourier Transform Infrared (FTIR)-, 1H Nuclear Magnetic Resonance (NMR)-spectroscopy and multivariate statistical analysis were used for the screening of in vitro anti-inflammatory activity on three different germplasm accessions namely 11,341 (P), 11,248 (T) and 11,265 (H) of Malaysian Andrographis paniculata (A. paniculata) leaf. The anti-inflammatory activity by nitric oxide (NO) inhibition assay in relation to the different harvesting ages and times of A. paniculata leaf was determined through comparison by partial least-squares analysis (PLS) using SIMCA-P. The PLS allowed the separation and correlation between the NO assay with the phytochemical present due to the effects of different harvesting ages and times. From the PLS plots, conclusions were drawn with respect to the correlation between A. paniculata leaf metabolites with the anti-inflammatory results which showed that 180 days after transplanting (DAT) of morning session for accessions T and H, and evening for P gave the highest anti-inflammatory activity.

关键词： Andrographis paniculata Anti-Inflammatory no inhibition Partial Least-Squares Analysis FTIR 1H NMR

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