Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(nmda)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of nmda IgA/IgM antibodies in patients with Parkinson disease...
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Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(nmda)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of nmda IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured nmda antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:nmda antibodies were analysed in the serum of patients and controls using well established validated *** used anti-nmda antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of nmda IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive nmda antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that nmda antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while nmda IgG antibodies define a separate disease of its own.
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