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Synergistic effect of oxymatrine and angiogenesis inhibitor nm-3 on modulating apoptosis in human gastric cancer cells

引用

World Journal of Gastroenterology 2007年第12期13卷 1788-1793页

作者： Ming-Quan Song Jin-Shui Zhu Jin-Lian Chen Long Wang Wei Da Li Zhu Wei-Ping Zhang Department of Gastroenterology The Sixth Affiliated Hospital of Shanghai Jiaotong University Shanghai 200233 China

AIM: To investigate the synergistic effect of oxymatrine(OM) and angiogenesis inhibitor nm-3 on modulatingapoptosis in human gastric cancer cell lines SGC-7901,MKN-45, MKN-74. METHODS: Human gastric cancer lines SGC-7901,MKN-45, MKN-74 were treated with OM in the absenceand presence of nm-3. The inhibitory rates weredetected by MTT assay. Synergistic effect of OM andnm-3 on the growth of survivin, bcl-2, bax and p53 inSGC-7901 cells were examined by semiquantitative RT-PCR and Western blotting, and their growth inhibitoryeffects were also observed on SGC-7901 tumor xenograftin nude ***: OM combined with nm-3 exhibited asynergistic inhibitory effect on the growth of SGC-7901,MKN-45 and MKN-74 cells in a time-dependent ***-four hours after treatment with OM, nm-3 aloneand their combination, mRNA expression of survivin andbcl-2 in SGC-7901 cells decreased, p53 mRNA expressionincreased. OM (4 g/L) combined with nm-3 significantlyincreased the expression of p53 mRNA and decreasedthe expression of survivin and bcl-2 compared witheither agent alone (193% ± 34% vs 129% ± 12%;44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%,P nm-3 on protein translation of survivin,bcl-2 and p 53 was in accordance with their ***, OM/nm-3 combination obviously exhibitedantitumor growth effect in xenografted human gastriccancer cells SGC-7901 compared with either agent ***: OM combined with nm-3 has synergisticinhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo.

关键词： nm-3 compound Oxymatrine Gastric cancer Apoptosis

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