检索结果-南通市图书馆

The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer(nk)cells do not predict the repeated implantation failure(RIF)for the in vitro fertilization patients

引用

Genes & Diseases 2020年第2期7卷 283-289页

作者： Hongzhan Zhang Chunyu Huang Xian Chen Longfei Li Su Liu Yuye Li Yongnu Zhang Yong Zeng Lina HuDepartment of Obstetrics and Gynecology The Second Affiliated Hospital of Chongqing Medical University Chongqing400010PR China Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation Shenzhen ZhongshanInstitute for Reproduction and GeneticsFertility CenterShenzhen Zhongshan Urology HospitalShenzhenGuangdong518045PR China

Natural killer(nk)cells are thought to play a key role in the successful establishment of a pregnancy by facilitating immunological adaptation of the semi-allogeneic developing *** aim of this study was to explore the cell number,immunophenotypic characteristics,and activities of peripheral blood nk cells in women with repeated implantation failure(RIF).Peripheral blood was obtained from 27 women with RIF and 11 healthy,fertile controls during the middle luteal phase of the menstrual ***3^-CD56^+nk cells were quantified and analyzed by flow cytometry for the expression of cytolytic molecules(granzyme B,granulysin,and perforin)as well as cell surface receptors responsible for nk cell activation or inhibition(nkG2D,nkp30,nkp46,CD158a,CD158b).nk cytotoxicity was measured at three effector-to-target cell *** with RIF and fertile controls did not differ significantly in the percentage of circulating CD3CD56t nk cells,or in the proportions of these cells that expressed granzyme B,granulysin,or *** two groups also did not differ significantly in the proportions of nk cells expressing the receptors nkG2D,nkp30,nkp46,CD158a or *** linear model analysis showed that nk cytotoxicity increased with effector-to-target cell ***,nk cytotoxicity did not differ significantly between patients with RIF and fertile *** results suggest that RIF is not associated with significant alterations in the number or function of peripheral blood nk cells.

关键词： Activating receptor Inhibitory receptor nk cytotoxicity Peripheral blood nk cells Repeated implantation failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Dual Effects of Interleukin-18 in Tumor Progression

引用

Cellular & Molecular Immunology 2007年第5期4卷 329-335页

作者： Sunyoung Park Soyoung Cheon Daeho Cho Department of Life Science Sookmyung Women's UniversityChungpa-Dong 2-KaYongsan-KuSeoul 140-742Korea

Interleukin-18 （IL-18） was discovered as an interferon-y-inducing factor and had a critical role in inflammatory and immune respouse. It stimulates natural killer （nk） and T cells and enhances Thl immune response. These activated immune cells eliminate cancer cells and virus-infected cells effectively. However, IL-18 has also been found to promote tumor progression. Higher expression or secretion level of IL-18 is detected in various cancer cells in comparison with normal control, and IL-18 is able to induce angiogenesis, migration/metastasis, proliferation and immune escape. These dual effects and the mechanism of IL-18 need to be investigated further as it relates to cancer.

关键词： IL-18 Th1 immune response nk cytotoxicity tumor progression immune escape

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：