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NON-INVASIVE MEASUREMENT OF DEEP TISSUE TEMPERATURE CHANGES CAUSED BY APOPTOSIS DURING BREAST CANCER NEOADJUVANT CHEMOTHERAPY:A CASE STUDY

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 361-372页

作者： SO HYUN CHUNG RITA MEHTA BRUCE J.TROMBERG A.G.YODH Department of Physics and Astronomy University of Pennsylvania 209 S.33rd StPhiladelphiaPA 19104USA Department of Medicine UC Irvine Healthcare 101 The City Drive SouthOrangeCA 92868USA Beckman Laser Institute Department of Biomedical Engineering University of CaliforniaIrvine1002 Health Sciences Rd IrvineCA 92612USA

Treatment-induced apoptosis of cancer cells is one goal of cancer ***,more heat is generated by mitochondria during apoptosis,especially the uncoupled apoptotic state,^(1,2) compared to the resting *** this case study,we explore these thermal effects by longitudinally measuring temperature variations in a breast lesion of a pathological complete responder during neoadjuvant chemotherapy(NAC).Diffuse Optical Spectroscopic Imaging(DOSI)was employed to derive absolute deep tissue temperature using subtle spectral features of the water peak at 975 nm.^(3)A significant temperature increase was observed in time windows during the anthracycline and cyclophosphamide(AC)regimen but not in the paclitaxel and bevacizumab *** concentration changes generally did not follow temperature,suggesting the measured temperature increases were likely due to mitochondrial uncoupling rather than a direct vascular effect.A simultaneous increase of tissue oxygen saturation with temperature was observed,suggesting that oxidative stress also contributes to *** preliminary,this study indicates longitudinal DOSI tissue temperature monitoring provides information that can improve our understanding of the mechanisms of tissue response during NAC.

关键词： Deep tissue temperature Diffuse Optical Spectroscopic Imaging apoptosis neoadjuvant chemotherapy breast cancer Bound water Index nir water absorption spectrum

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