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PHOSPHORYLATED NEUROFILAMENT EPITOPES IN THE ACHROMASIC NEURONS OF CORTICONIGRAL DEGENERATION

中华医学杂志(英文版) 1991年第12期104卷 1011-1017页

作者：王鲁宁 NeilW.Kowall EdwardP.Richardson Jr. 100853 Beijing Neuropathology Laboratory Chinese PLA General Hospital C. S. Kubik Laboratory for Neuropathology Massachusetts General Hospital Boston MA 02114 U. S. A.

By employing monoclonal phosphorylated neurofilaments antibody, we studied the abnormally pale-staining neurons in 3 cases of corticonigral de generation by the avidin-biotin immunoperoxidase method. For comparison, the central chromatolysis in anterior horn cells secondary to cervical spine fracture and "ballooned" neurons in a case of Pick's disease and a case of Alzheimer's disease were studied with similar procedure. Achromasic neurons in the case of corticonigral degeneration and ballooned neurons in Pick's disease and Alzheimer's disease showed positive immunostaining, while neurons with central chromatolysis secondary to axonal injury did not. Our observations show that the achromasic neurons in corticonigral degeneration contain phosphorylated neurofilaments which share common antigenic characteristics with ballooned neurons in Pick's disease and Alzheimer's disease. The absence of positive immunostaining in reactive central chromatolysis suggests that despite the similarities in appearance with the usual histopathologic stains this cytoplasmic change is pathogenetically different from that in the other neuronal disorders mentioned above.

关键词： MONOCLONAL-ANTIBODIES nervous-system PICKS DISEASE EXPRESSION PROTEINS

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Over-expression of c-fos mRNA in the hippocampal neurons in Alzheimer's disease

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Chinese Medical Journal 1998年第1期111卷 35-37页

作者：卢文甫米瑞发汤洪川刘淑红范明王鲁宁 Department of Neurology General Hospital of PLA Beijing 100853 China Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing 100850 China

Abstract Objective To analyze the relationship between the proto oncogene c fos change and neuronal degeneration in the hippocampus of the patients with Alzheimer's disease. Methods The post mortem human hippocampal tissues were divided into three groups, namely, the aged, the young and Alzheimer's disease (AD) groups. Each group consisted of 10 patients. The diagnosis of AD was made by clinical manifestation and argentatine (Bodian) staining. Patients of both the young and the aged groups had no neurological disorders. The proto oncogene c fos mRNA was investigated in the hippocampal neurons using the method of in situ hybridization. Results The optical density of stained area and the integral within proto oncogene c fos mRNA revealed a significant increase in the hippocampal neurons in cases of Alzheimer's disease as compared with the controls. Conclusions The over expression of the proto oncogene c fos might play a role in the pathological process of Alzheimer's disease. These changes might result from a suffering stage of the hippocampal neurons or from a compensatory mechanism in the surviving neurons which are not yet affected by the pathological process.

关键词： nervous-system PROTEIN BRAIN

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