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NAT Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病

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现代生物医学进展 2017年第17期17卷 I0003-I0004页

作者： Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig Laboratory of Molecular Neurobiology Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden Department of Molecular Neurosciences Center for Brain Research Medical University of Vienna Vienna Austria Department of Neuroscience Karolinska Institutet Stockholm Sweden Department of Pharmacology Faculty of Medicine Biomedical Research Institute of Malaga (IBIMA) Malaga University Malaga Spain Institute for Stem Cell Biology and Regenerative Medicine Stanford University Stanford California USA.

帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元（dopaminergic neuron）渐进性丧失。尽管当前的疗法旨在补充多巴胺水平，但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中，... 详细信息

帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元（dopaminergic neuron）渐进性丧失。尽管当前的疗法旨在补充多巴胺水平，但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中，来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法：将神经胶质细胞（glialcell）转化为活性的多巴胺能神经元，并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。

关键词：多巴胺能神经元星形胶质细胞帕金森病治疗神经退行性疾病 NAT 重编程神经胶质细胞

Profile of Dr. Zi-Jiang Chen

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Science China(Life Sciences) 2020年第6期63卷 845-848页

作者： Chen, Zi-Jiang

Dr. Chen received her bachelor-equivelent medical education at School of Medicine Shandong University (previously the Shandong Medical College), and got her MD–Ph D in1989 majoring in Obstetrics and Gynecology. As the youngest professor in the school’s history, Dr. Chen joined the faculty of School of Medicine Shandong University.

关键词： NAT Profile of Dr Zi-Jiang Chen

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

NAT Immunol:科学家阐明如何有效抑制自身免疫疾病的发生

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现代生物医学进展 2017年第8期17卷 I0002-I0003页

作者： Thomas H auml ggl #x000F6 f, Saikiran K Sedimbi Mikael C I Karlsson Jennifer L Yates Elizabeth A Leadbetter Roham Parsa Robert A Harris Briana Hauff Salas Elizabeth A Leadbetter Department of Microbiology Tumor and Cell Biology Karolinska Institutet Solna Sweden. Trudeau Institute Saranac Lake New York USA. Department of Clinical Neuroscience Karolinska Institutet Centre for Molecular Medicine Karolinska University Hospital at Solna Solna Sweden. Department of Microbiology Immunology and Molecular Genetics University of Texas Health Science Center at San Antonio San Antonio Texas USA.

机体免疫系统中一种未知的安全机制能够保持机体免于自身免疫疾病，日前一项刊登于国际杂志NATure Immunology上的研究报告中，来自瑞典卡罗琳学院的研究人员通过研究发现。机体先天性免疫系统中的细胞能够阻止后天性的免疫系统对机体... 详细信息

机体免疫系统中一种未知的安全机制能够保持机体免于自身免疫疾病，日前一项刊登于国际杂志NATure Immunology上的研究报告中，来自瑞典卡罗琳学院的研究人员通过研究发现。机体先天性免疫系统中的细胞能够阻止后天性的免疫系统对机体固有的细胞产生反应，否则就会引发诸如系统性红斑狼疮等自身免疫疾病的发生。

关键词：自身免疫疾病机体免疫系统 NAT 科学家系统性红斑狼疮安全机制研究人员后天性

NAT Biotechnol:科学家成功绘制出单细胞中短链RNA分子的图谱

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现代生物医学进展 2017年第8期17卷 I0001-I0002页

作者： Omid R Faridani, Ilgar Abdullayev, Michael Hagemann-Jensen Rickard Sandberg Ilgar Abdullayev Rickard Sandberg Michael Hagemann-Jensen John P Schell Fredrik Lanner John P Schell Fredrik Lanner Ludwig Institute for Cancer Research Stockholm Sweden. Department of Cell and Molecular Biology Karolinska Institutet Stockholm Sweden. Respiratory Medicine Unit Department of Medicine Solna & Center for Molecular Medicine Stockholm Sweden. Department of Clinical Science Intervention and Technology Karolinska Institutet Stockholm Sweden. Division of Obstetrics and Gynecology Karolinska University Hospital Stockholm Sweden.

近日，刊登在国际杂志NATure Biotechnology上的一项研究报告中，来自瑞典卡罗琳学院的研究人员通过研究成功在单个胚胎干细胞中测定了短链非编码RNA序列的绝对数量。当基因中的信息被使用时，比如当其编码蛋白质时，首先DNA会转录成为... 详细信息

近日，刊登在国际杂志NATure Biotechnology上的一项研究报告中，来自瑞典卡罗琳学院的研究人员通过研究成功在单个胚胎干细胞中测定了短链非编码RNA序列的绝对数量。当基因中的信息被使用时，比如当其编码蛋白质时，首先DNA会转录成为信使RNA来作为蛋白质制造的范本，

关键词： RNA序列短链 NAT 单细胞科学家编码蛋白质图谱分子

Topological Shape Changes Weaken the InNATe Defensive Response to Visual Threat in Mice

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Neuroscience Bulletin 2020年第4期36卷 427-431页

作者： Yan Huang Lei Li Kun Dong Hongsi Tang Qingning Yang Xianglian Jia Yundan Liao Wenbo Wang Zhen Ren Lin Chen Liping Wang The Brain Cognition and Brain Disease Institute(BCBDI) Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsGuangdong Key Lab of Brain ConnectomicsShenzhen 518055China University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsCASUniversity of the CASBeijing 100101China

Understanding the primitives of visual perception is a fundamental question in the study of vision.T o address this question,a theory of topology-based functional hierarchy in visual perception has been proposed[1,2].This theory suggests that the extraction of topological properties(TPs)serves as the starting point of object perception.The T P of a figure is the holistic identity which remains constant across various smooth shape-changing transformations of an image[2].

关键词： Visual NAT starting

Evolutionary ecology of chemosensation and its role in sensory drive

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Current Zoology 2018年第4期64卷 525-533页

作者： Laurel R. YOHE Philipp BRAND Department of Ecology and Evolution Stony Brook University Stony Brook NY 11790 USA Department of Geology & Geophysics Yale University New Haven CT 06511 USA Department of Evolution and Ecology Center for Population Biology University of California Davis CA 95616 USA

All behaviors of an organism are rooted in sensory processing of signals from its environment, and NATural selection shapes sensory adaptations to ensure successful detection of cues that maximize fitness. Sensory drive, or divergent selection for efficient signal transmission among heterogeneous environments, has been a useful hypothesis for describing sensory adaptations, but its current scope has primarily focused on visual and acoustic sensory modalities. Chemosensation, the most widespread sensory modality in animals that includes the senses of smell and taste, is characterized by rapid evolution and has been linked to sensory adaptations to new environments in numerous lineages. Yet, olfaction and gustation have been largely underappreciated in light of the sensory drive hypothesis. Here, we examine why chemosensory systems have been overlooked and discuss the potential of chemosensation to shed new insight on the sensory drive hypothesis and vice versa. We provide suggestions for developing a framework to better incorporate studies of chemosensory adaptation that have the potential to shape a more complete, coherent, and holistic interpretation of the sensory drive.

关键词：进化生态学开车信号传播乌拉尔山脉改编有机体 NAT 最大化

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云环境中的终端接入技术研究与实现

云环境中的终端接入技术研究与实现

作者：罗丹梅电子科技大学

学位级别：硕士

随着云平台的发展,终端接入技术被广泛应用,本文对主流的终端接入技术进行了详细的学习和研究。在它们的多种实现中,Open VPN以其低部署成本、高兼容性成为了许多中小型机构和组织的选择。因此,本文选择Open VPN作为主要研究对象,对其... 详细信息

随着云平台的发展,终端接入技术被广泛应用,本文对主流的终端接入技术进行了详细的学习和研究。在它们的多种实现中,Open VPN以其低部署成本、高兼容性成为了许多中小型机构和组织的选择。因此,本文选择Open VPN作为主要研究对象,对其原理、应用场景、工作流程以及性能展开了研究与分析,提出了一种基于数据平面开发套件（Data Plane Development Kit,DPDK）的性能优化方案。本文详细研究了OpenVPN三个主要功能模块的工作流程,采用实验和文献学习的方式分析它们产生的开销对Open VPN性能的影响。得到分析结果后,本文针对Open VPN的数据接收模块和数据转发模块设计并实现了基于DPDK的优化方案。数据接收模块的优化方案基于DPDK收发包平台和F-Stack的用户态协议栈以及DPDK的内核-网卡接口（Kernel NIC Interface,KNI）组件,在实现Open VPN对数据包的高速、低开销读取的同时,结合Open VPN的隧道认证业务,实现了控制面与数据面的分离。数据转发模块的优化方案同样基于DPDK收发包平台,但为了兼容Open VPN特殊的数据结构和仍然使用TUN设备的客户端,不经过F-Stack用户态协议栈,因此在DPDK数据处理的基础上设计并实现了简单的ARP和NAT功能,在保障与内网通信的同时,减少了数据转发的开销。按照本文提出的方案对OpenVPN优化后,进行时延与网络吞吐率的测试,测试结果显示,在相同的测试环境下,相较于优化前的Open VPN,利用DPDK等技术进行优化的Open VPN服务端的时延整体更低,降低了6.3%,网络吞吐率更高,上升了16.2%,实现了OpenVPN网关性能的提升。

关键词：终端接入技术 OpenVPN 数据面开发套件 NAT

InNATe immune responses to DNA viruses

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Protein & Cell 2013年第1期4卷 1-7页

作者： Ying Nie Yan-Yi Wang Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China Graduate University of Chinese Academy of Sciences Beijing 100049China

The inNATe immune system acts as the first line of defense against pathogens,which is also essen-tial for initiation of adaptive immunity.InNATe immune responses are initiated by pattern-recognition receptors(PRRs),which recognize conserved molecular structures of pathogens called patho-gen-associated molecular patterns(PAMPs).The infection of virus triggers a series of signaling events leading to transcriptional induction of type I interferons(IFNs)and proinflammatory cyto-kines.In recent years,the mechanisms of viral RNA recognition and RNA virus-triggered signaling pathways have been well studied.However,it remains unclear on how DNA virus infection is sensed by host cells and triggers the host antiviral defense.Although ten potential viral DNA sen-sors have been reported,none of them is validated as a generally used sensor for distinct DNA viruses in divergent cell types and animals.Here,we provide a summary and perspective on recent advances in inNATe immune responses to DNA viruses.

关键词： initiated NAT pattern