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Synthesis and antibacterial evaluation of 2-substituted-4,5-diphenyl-n-alkyl imidazole derivatives

Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 471-474页

作者： Abhishek K Jain V Ravichandran Madhvi Sisodiya RK Agrawal Pharmaceutical Chemistry Research Laboratory Department of Pharmaceutical SciencesDr.Hari Singh Gour UniversitySagar(M.P)-470 003India Faculty of Pharmacy AIMST UniversitySemeling-08100KedahMalaysia Pharmaceutical Chemistry Research Laboratory Department of Pharmaceutical SciencesDr.Hari Singh Gour UniversitySagar(M.P)-470003India

Objective:To synthesis 2-substituted-4,5-diphenyl-n- alkyl imidazole derivatives,and evaluate their antibacterial ***:A mixture of benzil（10 mmol） and ammonium acetate（0.1 mol）（immediately fused） in glacial acetic acid（25 mL） was stirred at 80-100℃for 1 h under nitrogen atmosphere（to prevent incorporation of any atmospheric impurities and moisture）. Substituted aldehydes（10 mmol） in glacial acetic acid（5 mL） was added drop-wise over a period of 15-20 min at the same temperature and stirred for another 4 h,the progress of the reaction was monitored by TLC test using ethyl acetate as *** newly synthesized compounds were characterized by IR,1HnMR,13CnMR and by mass ***:All the synthesized compounds were confirmed by spectroscopical techniques and evaluated for antimicrobial activity against Staphylococcus aureus（***）,Bacilus subtilus（***）,and Escheria coli （***）.These compounds showed antibacterial activity（zone of inhibition） against *** ranged from 3 mm to 9 mmin diameter,***,4 -8 mm,and *** 5 -12 *** of 2a-2e, only 2a and 2b showed some sort of activity but none of them had considerable activity compared with that of the ***:All the synthesized compounds show moderate activity against the tested bacteria ***,***,and ***,further structural modification is necessary to improve the antibacterial action of 2-substituted-4,5-diphenyl-n-alkyl imidazole derivatives.

关键词： Antibacterial activity Imidazole derivatives n-alkyl imidazole

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STUDIES On BIPYRIDInIUM SALTS AnD THEIR POLYMERS Ⅰ. SYnTHESIS OF 4, 4’-(1, 4-PHEnYLEnE-)BIS-[n-alkyl (ARYL)-2, 6-DIPHEnYL-] PYRIDInIUM SALTS AnD THEIR POLYMERS FROM CORRESPOnDInG BIPYRYLIUM SALT

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高分子科学(英文版) 1985年第3期 185-193页

作者：杨玉崑 Insitute of Chemistry Academia Sinica Beijing

The reaction of pyrylium salt with primary amine has been utilized to synthesize 4,4’-bipyri-dinium salts and pyridinium polymers. Seven new 4,4’-(1,4-phenylene-) bis-[n-alkyl(aryl)-2,6-diphenyl-] pyridinium perchlorates 4 and five corresponding bipyridinium polymers 5 were preparedwith good yields from 4,4’-(1,4-phenylene-) bis-(2,6-diphenyl-) pyrylium perchlorate 3. Preliminarytests have been made for their redox behavior and catalytic activity.

关键词： phenylene alkyl ARYL BIS DIPHEnYL n-alkyl PHEnYLEnE SYnTHESIS OF 4 diphenyl synthesize

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Analogs of Antifungal Indoles Isolated from Aporpium Caryae with Activity Against Sudden-Death Syndrome of Soybean

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American Journal of Plant Sciences 2011年第2期2卷 245-254页

作者： Brenda Bertinetti Mercedes Scandiani Gabriela Cabrera 不详

Based on the precedent discovery of a weak antifungal indole isolated from Aporpium caryae, which increased its activity when changing the n-alkyl chain, nineteen n-alkyl indoles, with alkyl chains from one to ten carbons and one or two hydroxyls, one amine or bromine functional groups, were prepared and fully characterized by spectroscopic methods. The aim of this study is the search for new synthetic agrochemical leads derived from natural products. The antifungal activity of the synthesized compounds against three fungal strains was measured in vitro. Six compounds presented good activity against Fusarium virguliforme, the causal agent of sudden-death syndrome (SDS) in soybean, in a bioautography assay. Four of them were tested in a germination test and in a greenhouse experiment. All tested compounds, applied as seed treatment, showed antifungal properties being effective to control SDS when there was low level of fungal contamination. Results indicate that some of the tested compounds are acting as growth inhibitors and represent new leads for the treatment of SDS for which no specific treatment has been previously reported.

关键词： n-alkyl Indole Soybean Phytopathogen Fusarium Virguliforme Sudden-Death Syndrome

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