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myxoid and Lipomatous Solitary Fibrous Tumor of Soft Tissue: A Case Description

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Open Journal of Pathology 2017年第1期7卷 20-24页

作者： Javier Ortiz Rodríguez-Parets Cristina González Velasco Elisa Muñ oz Torres María Dolores Ludeñ a de la Cruz Departamento de Anatomía Patológica Hospital Universitario de Salamanca Salamanca Spain

We present a case of a myxoid and lipomatous solitary fibrous tumor that was observed in a 67-year-old man. The tumor, which had a maximum diameter of 10 cm, was located in the soft tissues of the dorsal region and appeared macroscopically well delimited and encapsulated. Upon cutting, a markedly gelatinous internal surface was observed. A microscopic study revealed an intense and diffusely myxoid neoplasia, with small areas of adipose aspect, in which histological (staghorn vessels, perivascular hyalinization, fusiform cells of benign aspect) and immunohistochemical (intensive positivity for CD34, Bcl-2 and Cd99 and negativity for muscle markers) data were consistent with a solitary fibrous tumor were observed. To conclude, the main characteristics of this lesion are discussed, and a differential diagnosis is established with other entities.

关键词： Solitary Fibrous Tumor myxoid and Lipomatous Differentiation Histopathology Immunohistochemistry

myxoid Degeneration of Ovarian Tumor in Young Patient,Laparoscopic Approach

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Journal of Pharmacy and Pharmacology 2019年第12期7卷 623-626页

作者： Sofoudis Chrisostomos Dedoulis Evaggelos Zioris Konstantinos Department of Obstetrics and Gynecology Konstandopoulio General HospitalAthensGreece Mitera Maternal HospitalAthensGreece

myxoid degeneration of ovarian tumors represents a rare distinctive benign ovarian stromal neoplasm that occurs predominantly in young women and is hormonally inactive.According to recent bibliography,pathogenesis remains controversial.Many conducted studies express the strong belief adjusting myxoid ovarian tumors with genetic abnormalities.Therapeutic mapping is associated with histologic confirmation of the lesion.In cases of premenopausal patients,fertility preservation consists of ultimate scope.Abdominal MRI(magnetic resonance imaging)along with transvaginal ultrasound can differentiate and depict all preoperative imaging findings.myxoid degenerated ovarian tumors can be malignant transformed into myxoid leiomyosarcomas with extremely metastatic possibilities.Meticulous atomic history,proper laboratory and imaging findings reflect successful key concerning ultimate diagnosis and treatment.

关键词： Ovarian tumor myxoid degeneration laparoscopy

Gastrointestinal Stromal Tumor (GIST) with Chondroid-myxoid-Chordoid Features Mimicking Extraskeletal myxoid Chondrosarcoma

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Open Journal of Pathology 2012年第3期2卷 85-89页

作者： Sonia Brar Christian Tvetenstrand Jagmohan Sidhu Department of Medicine UHS Hospitals Johnson City USA Department of Pathology and Laboratory Medicine UHS Hospitals Johnson City USA Department of Surgery UHS Hospitals Johnson City USA

Epithelioid gastrointesinal tumors (GISTs) are less likely to have c-kit gene mutations (and express CD117) than spindle cell GISTs. CD117 negative/c-kit negative GISTs can have platelet-derived growth factor alpha (PDGFRα) gene mutations, overexpress PDGFRα protein and respond to imatinib mesylate. Many cases of CD117-negative/CD117-weakly positive, c-kit mutation negative and PDGFRα mutation positive myxoid epithelioid GISTs and one case of CD117-positive GIST with chondro-myxoid features mimicking chondrosarcoma have been reported. We report a case of myxoid epithelioid GIST with predominance of chondroid and chordoid areas resembling an extraskeletal myxoid chondrosarcoma that was strongly positive for CD117, PDGFRα and DOG1 (Discovered on GIST 1) by immunohistochemistry, but lacked c-kit and PDGFRα gene mutations. It is possible that CD117 is strongly positive if a myxoid epithelioid GIST has chondroid/chordoid appearance, but a larger study is needed to confirm this association. CD117 expression in GISTs is important, because GISTs showing CD117 positivity respond to imatinib. No comment can be made about the prognostic significance of chondroid/chordoid appearance in the GISTs.

关键词： Gastrointestinal Stromal Tumor GIST PDGFRα CD117 c-kit Extraskeletal myxoid Chondrosarcoma

Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion:a case report and review of literature

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Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion:a c...