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Efficacy of Frankincense and myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome

Chinese Journal of Integrative Medicine 2020年第7期26卷 519-526页

作者： Yung-Hsiang Chen Wen-Chi Chen Kao-Sung Tsai Po-Len Liu Ming-Yen Tsai Tzu-Chun Lin Shih-Chieh Yu Huey-Yi Chen Graduate Institute of Integrated Medicine College of MedicineResearch Center for Chinese Medicine and AcupunctureChinese Medicine Research CenterChina Medical UniversityTaichungTaiwanChina Departments of Medical Research Urologyand Obstetrics and GynecologyChina Medical University HospitalTaichungTaiwanChina Department of Psychology College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Department of Applied Cosmetology Master Program of Cosmetic ScienceHungkuang UniversityTaiwanChina Department of Respiratory Therapy College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Chinese Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwanChina Department of Dermatology Chung Shan University HospitalInstitute of MedicineSchool of MedicineChung Shan Medical UniversityTaichungTaiwanChina Department of Neurology Kuang Tien General HospitalTaichungTaiwanChina

Objective:To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome(IC/PBS).Methods:The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial cells(HUCs)were assessed in *** the animal study,48 virgin female rats were randomized into 4 groups(12 in each group):(1)control group(saline-injected control);(2)cyclophosphamide(CYP)group(intraperitoneal injected 150 mg/kg CYP);(3)CYP+pentosan polysulfate sodium group(orally received 50 mg/kg pentosan polysulfate sodium);and(4)CYP+frankincense and myrrha group[orally received frankincense(200 mg/kg)and myrrha(200 mg/kg)].Rats orally received pentosan polysulfate sodium or frankincense and myrrha on day 1,2,and *** experiments were performed on day *** and cystometry assessment behavior test were *** interval values were assessed in rats under ***,immunohistochemistry and Western blot were used to confirm the location and level,respectively,of cell junction-associated protein zonula occludens-2(ZO-2)***:Low dose frankincense and myrrha increased cell proliferation and migration in HUCs compared with control(Pmyrrha group than CYP group(Pmyrrha groups compared with the CYP-induced acute IC/PBS group(Pmyrrha modulate urothelial wound healing,which ameliorates typical features of acute IC/PBS in rats.

关键词： frankincense myrrha acute interstitialcystitis painful bladder syndrome cell junction-associated protein

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A thermosensitive gel formulation of an empirical traditional Chinese prescription for treating cervical erosion

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Acta Pharmaceutica Sinica B 2012年第5期2卷 495-501页

作者： Shuqing Zhou Xiaoling Zheng Caihong Zheng Fan Qu Xuefen Cai Juanhua Xu Women’s Reproductive Health Laboratory of Zhejiang Province and Department of Pharmacy Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective *** this study,extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri,Rhizoma Coptidis,Olibanum,myrrha,borneol and catechu were formulated to facilitate intravaginal administration and improve *** extract of the first four components was formulated with borneol as a thermosensitive gel(TG)while an extract of catechu used to prepare a regular gel(CG)because of a chemical *** optimized TG was prepared using poloxamer 407 and poloxamer *** CG was prepared using glycerin,carbopol and *** gels were characterized in vitro in terms of release of berberine(TG)and total catechins(CG)and in vivo in a rat model of cervical *** tment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal *** formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.

关键词： Thermosensitive gel Traditional Chinese prescription Cervical erosion Berberine Poloxamer Rat Cortex Phellodendri Rhizoma Coptidis Olibanum myrrha Borneol catechu

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