检索结果-南通市图书馆

LINc01268 promotes epithelial-mesenchymal transition,invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARcKS

引用

World Journal of Gastrointestinal Oncology 2023年第8期15卷 1366-1383页

作者： Ling-Han Tang Peng-cheng Ye Lin Yao Ya-Jun Luo Wang Tan Wan-Ping Xiang Zi-Lin Liu Ling Tan Jiang-Wei Xiao Department of Gastrointestinal Surgery Clinical Medical College and the First Affiliated Hospital of Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery Yaan People’s HospitalYaan 625000Sichuan ProvinceChina Department of Thoracic Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Surgery People’s Hospital Affiliated to Chongqing Three Gorges Medical CollegeChongqing 404041China

BAcKGROUND Long non-coding RNAs(lncRNAs)with differential expression characteristics have been found to be closely related to the tumorigenesis and development of gastric cancer(Gc),but their specific mechanisms and roles still need to be further *** To investigate the expression of LINc01268 in Gc and its mechanism of affecting Gc *** Real-time quantitative polymerase chain reaction was used to detect the expression of LINc01268 in Gc tissues,cell lines and *** Kaplan-Meier method was used to evaluate the value of LINc01268 in the prognostication of Gc *** receiver operating characteristic curve was constructed to evaluate the value of LINc01268 in the diagnosis of *** migration and invasion assays and wound healing assays were used to confirm the effect of LINc01268 on the invasion and migration of Gc *** regulatory relationship between LINc01268 and myristoylated alanine rich protein kinase c substrate(MARcKS),the PI3K/Akt signaling pathway,and the epithelial-mesenchymal transition(EMT)process in Gc was demonstrated by western blot *** The expression of LINc01268 was increased in Gc tissues and cell *** expression level of LINc01268 was significantly correlated with lymph node metastasis,TNM stage,and tumor differentiation in patients with ***-expression of LINc01268 indicated a poor prognosis for patients with Gc,and it had a certain auxiliary diagnostic value for *** vitro functional experiments proved that the abnormal expression of LINc01268 further activated the PI3K/Akt signaling pathway and promoted EMT by targeting and regulating MARcKS and ultimately promoted the invasion and metastasis of *** This study elucidates that LINc01268 in Gc may be an oncogene that further activates the PI3K/Akt signaling pathway and EMT by targeting and regulating MARcKS,and ultimately promotes the invasion and metastasis of ***01268 may be a potential effective target for the trea

关键词： Gastric cancer Long non-coding RNA LINc01268 myristoylated alanine rich protein kinase c substrate Invasion Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：