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Diagnosing CAD: additional markers from myocardial perfusion spect

The Journal of Biomedical Research 2013年第6期27卷 467-477页

作者： Guang-Uei Hung Chang Bing Show Chwan Memorial Hospital

Over the past decades, stress/rest myocardial perfusion spect （MPS） has been utilized as a standard modality for the diagnosis, risk stratification and prognostic assessment of coronary artery disease （CAD）. In addition to the perfusion information, MPS can also provide functional information of the left ventricle, including volume, ejec- tion fraction, wall motion and dyssynchrony. This article introduces the incremental value of these non-perfusion parameters as markers and prognosticators of CAD.

关键词： coronary artery disease additional markers myocardial perfusion spect

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Comparison of ^(99m)Tc-methoxyisobutylisonitrile myocardial single-photon emission computed tomography and electron beam computed tomography for detecting coronary artery disease in patients with no myocardial infarction

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Chinese Medical Journal 2004年第5期117卷 700-705页

作者：姚稚明李伟屈婉莹周诚何青季福绥 Department of Nuclear Medicine Department of Radiology Department of Cardiology

Background Previous studies have compared single-photon emission computed tomography (spect) and electron beam computed tomography (EBCT) in detection of coronary artery disease (CAD) in patients with myocardial infarction (MI) The purpose of this study was to compare spect with EBCT in detection of CAD in patients with no MI Methods One hundred and forty-seven patients with suspected CAD underwent stress-rest 99m Tc-methoxyisobutylisonitrile ( 99m Tc-MIBI) myocardial spect, cardiac EBCT and coronary angiography (CAG) within one month Of them, 73 patients (aged 52 6±10 6 years old) with no history of MI were included in this study Coronary artery calcium (CAC) was defined as a CT value ≥130 HU within the boundary of coronary artery on EBCT Results There were 35 and 38 patients with or without CAD according to CAG Ninety-six percent of the patients with abnormal spect and CAC had a coronary arteries stenosis ≥50%, and 90 9% patients with normal spect and EBCT showed no CAD The sensitivity of spect and EBCT in detection of CAD was comparable, and the specificity of spect (92 1%) was significantly higher than that of EBCT (55 3%) ( P spect (75 0% and 93 7%) were significantly higher than those of EBCT (53 3% and 76 7%) ( P spectively) In patients without chest pain, the sensitivity and specificity of spect (76 9% and 91 4%) were significantly higher than those of EBCT (23 1% and 69 0%) in detection of a coronary artery stenosis of ≥50% ( P spectively) However, in patients with chest pain, both sensitivity and specificity of spect were comparable to those of EBCT In patients ≤45 years old, the sensitivity of spect (77 8%) was significantly higher than that of EBCT (27 8%) in assessing a coronary artery stenosis of ≥50% ( P <0 005), and the specificity of SPEC

关键词： coronary artery disease myocardial perfusion spect coronary calcium electron beam CT

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A New Approach to the Presentation of myocardial spect Images——Radial Slices——Data Reduction without Loss of Information

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Engineering（科研） 2013年第10期5卷 113-117页

作者： Niloufar Darvish Fatma Nadide Ocba Hamed Hamid Muhammed Dianna Bone School of Technology and Health STH Royal Institute of Technology KTHAlfred Nobels Alle10SE-14152 HuddingeSweden Department of Clinical Physiology Thoracic ClinicsKarolinska HospitalSE-17671 StockholmSweden

Objective: spect data from myocardial perfusion imaging (MPI) are normally displayed as a set of three slices orthogonal to the left ventricular (LV) long axis. For data presentation, the images are orientated about the LV long axis. Therefore, radial slices provide a suitable alternative to standard orthogonal slices, with the advantage of requiring fewer slices to adequately represent the data. In this study, a semi-automatic method is developed for displaying MPI spect data as a set of radial slices orientated about the LV axis. The aim is to reduce the number of slices viewed without loss of information and independently from the heart size. Method: Standard short axis slices, orientated perpendicular to the LV axis, are *** skeleton of the segmented myocardium is found and the true LV axis is determined in each central long slice. The LV axis of the whole volume is determined by aligning the axes of all slices. Result: Radial slices centered about this axis were generated by integration over a sector equal to the resolution of the imaging system which was of the order of 1.2 cm. Therefore, assuming a mean LV diameter of 8 cm, 20 slices were sufficient to represent a non-gated study. Gated information could be adequately displayed with 4 slices integrated over an angle of 45. Conclusion: A semi-automatic method for generating radial slices from spect MPI short axis slices has been developed.

关键词： myocardial perfusion spect Cardiac Left Ventricle Radial Slices Left Ventricular Long Axis

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