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Virologica Sinica 2023年第6期38卷 940-950页

作者： Wu He Ke Xu Li Ni Junfang Wu Yuxuan Zhang Kun Miao Luyun Wang Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

myocardial injury is one of the most common comorbidity in SARS-CoV-2 infected patients,and has poor ***,the incidence of myocardial injury in patients with SARS-CoV-2 infection has not been sufficiently investigated during the Omicron *** conducted a retrospective study of 2690 patients with confirmed SARS-CoV-2 Omicron infection from Tongji *** results indicated that the myocardial injury accounted for 30.8%of the total patients with SARS-CoV-2 infection and was associated with higher in-hospital mortality than those without injury before and after propensity score matching(PSM)[adjusted hazard ratio(HR),10.61;95%confidence interval(CI),7.76–14.51;Pmyocardial injury were higher than those without injury,and the higher levels of cytokines in the myocardial injury group were associated with increased *** of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers(ACEI/ARB)could significantly reduce the mortality in patients with myocardial injury(adjusted HR,0.52;95%CI,0.38–0.71;Pmyocardial injury group compared to those without ***,the study summarized the clinical characteristic and outcome of SARS-CoV-2 infected patients with myocardial injury during the Omicron wave in China,and validated the protective role of ACEI/ARB in improving the survival of those with myocardial injury.

关键词： COVID-19 Omicron myocardial injury In-hospital mortality Cytokine storm

myocardial injury:where inflammation and autophagy meet

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Burns & Trauma 2023年第1期11卷 188-202页

作者： Chunping Liu Yanjiao Liu Huiqi Chen Xiaofei Yang Chuanjian Lu Lei Wang Jiahong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou51080China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou510080China

Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular *** of autophagy can be observed during myocardial injury,during which inflammatory responses are strongly *** can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged *** addition,autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged *** this paper,we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions,including myocardial ischemia,ischemia/reperfusion injury and sepsis cardiomyopathy.

关键词： Autophagy Inflammation myocardial injury

Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury

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Journal of Pharmaceutical Analysis 2024年第11期14卷 1567-1587页

作者： Kai Yang Ping Zhang Jixin Li Genming Zhang Xing Chang Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China Shandong University of Traditional Chinese Medicine Jinan250355China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing100091China

myocardial injury(MI)is a common occurrence in clinical practice caused by various factors such as ischemia,hypoxia,infection,metabolic abnormalities,and *** damages are characterized by a reduction in myocardial function and cardiomyocyte death that can result in dangerous outcomes such as cardiac failure and *** endoplasmic reticulum stress(ERS)-induced unfolded protein response(UPR)is triggered by several stressors,and its intricate signaling networks are instrumental in both cell survival and *** damage frequently triggers ERS in response to different types of injuries and *** levels of ERS can exacerbate myocardial damage by inducing necrosis and *** target ERS in MI prevention and treatment,current medical research is focused on identifying effective therapy *** Chinese medicine(TCM)is frequently used because of its vast range of applications and low risk of adverse *** studies have demonstrated that active components of Chinese medicines,including polyphenols,saponins,and alkaloids,can reduce myocardial cell death,inflammation,and modify the ERS pathway,thus preventing and mitigating cardiac ***,this paper aims to provide a new direction and scientific basis for targeting ERS in MI prevention and *** specifically summarize recent research progress on the regulation mechanism of ERS in MI by active ingredients of TCM.

关键词： Natural products Endoplasmic reticulum stress myocardial injury Unfolded protein response Cardiovascular disease

Moxibustion enables protective effects on rheumatoid arthritis-induced myocardial injury via transforming growth factor beta1 signaling and metabolic reprogramming

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1190-1199页

作者： WANG Miao ZHU Yan ZHAO Hui ZHAO Hongfang the Geriatrics Anhui University of Traditional Chinese MedicineHefei 230031China the Geriatrics the Second Hospital Affiliated of Anhui University of Traditional Chinese MedicineHefei 230061China

OBJECTIVE:To examine the effects of moxibustion on myocardial injury and myocardial metabolomics in rats with rheumatoid arthritis(RA)based on the transforming growth factor beta1(TGF-β1)/Smads signaling ***:One hundred rats were treated with saline[normal control(NC)group]or complete Freund’s adjuvant(CFA)by right plantar injection for the RA model group,and the latter were randomly divided into 4 *** wilfordii polyglycoside tablets(雷公藤多苷片,TPT)have anti-inflammatory and are widely used in the clinical treatment of RA,therefore serving as a positive control *** days post injection rats were given TPT tablet(TPT group),acupuncture therapy(APT group),and moxibustion treatment(MOX group)for 15 consecutive days,while NC group and model group were equally grasped and fixed and received normal *** joint swelling scores and arthritis index(AI)were evaluated in each group before the CFA challenge,therapy and after receiving *** ultrastructure was observed by electron ***-linked immunosorbent assay was used to detect cardiac troponin I(cTnI)levels in rat myocardial *** reverse transcription polymerase chain reaction and Western blotting analysis were used to measure the mRNA and protein levels of TGF-βsignaling molecules including TGF-β1,Smad2,Smad3,Smad4,and *** metabolomics was analyzed using gas chromatography-mass ***:Compared with model group,RA model rats receiving TPT,acupuncture,or moxibustion therapy all showed reduced joint swelling scores and AI(all Pmyocardial damage,whereas rats treated with moxibustion were found to be more ***,the expressions of cTnI,TGF-β1,Smad2,Smad3,and Smad4 were found to be elevated in model rat group in contrast to NC rats and were significantly downregulated in TPT,APT and MOX group when compared with model group,while the levels of Smad7 showed the opposite result(all P<0.01).Moreover,

关键词： moxibustion arthritis rheumatoid transforming growth factor beta1 smad proteins signal transduction myocardial injury metabolomics

Influence of Microcirculatory Dysfunction on myocardial injury after Cardiopulmonary Resuscitation

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Biomedical and Environmental Sciences 2022年第4期35卷 334-344页

作者： YANG Jun DONG Gui Juan WANG Hong Wei ZHAO Xin WANG Fu Jun ZHANG Jian GUO Shu Bin Emergency Medicine Clinical Research Center of Beijing Chaoyang Hospital Capital Medical UniversityBeijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijing 100020China

Objective This study aimed to examine the effects of microcirculatory dysfunction and 654-1intervention after cardiopulmonary resuscitation on myocardial *** Landrace pigs were divided into a sham operation group(S group,n=6),ventricular fibrillation control group(VF-C group,n=8)and 654-1 intervention group(VF-I group,n=8).Hemodynamics was recorded at baseline,at recovery of spontaneous circulation(ROSC),and 1 h,2 h,4h and 6 h *** dark field(SDF)technology was used to evaluate and monitor the microcirculation flow index,total vessel density,perfusion vessel ratio,De-Backer score,and perfusion vessel density in animal viscera at various time *** After administration of 654-1 at 1.5 h post-ROSC,the hemodynamics in the VF-I group,as compared with the VF-C group,was significantly *** visceral microcirculation detected by SDF was also significantly improved in the VF-I *** observed through electron microscopy,significantly less myocardial tissue injury was present in the VF-I group than the VF-C *** Administration of 654-1 inhibited excessive inflammatory by improving the state of visceral microcirculation.

关键词： Cardiopulmonary resuscitation Post-cardiac arrest syndrome Microcirculation dysfunction myocardial injury Anisodamine hydrobromide(654-1)

Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation

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Bioactive Materials 2023年第6期24卷 313-321页

作者： Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen School of Medical Technology Tianjin Medical UniversityTianjin300203China Department of Molecular Pharmacology School of MedicineNankai UniversityTianjin300071China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou571199China Department of Radiology The Second Hospital of Tianjin Medical UniversityTianjin300211China Tianjin Key Laboratory of General Surgery in Construction Tianjin Union Medical CenterTianjin300000China Xinjiang Production and Construction Corps Hospital Xinjiang830092China

myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with *** studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart ***,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac ***,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling *** LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced *** vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial ***,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future.

关键词： Sepsis myocardial injury Melanin nanoparticles Ferroptosis Inflammation

Relationship Between myocardial injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease

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Current Medical Science 2022年第1期42卷 85-92页

作者： Shuai JIANG Qian-ru YE Rong-xia ZHEN Juan-niu ZHANG Yi-yi ZHANG Xu LIU Jie HOU Institute of Keshan Disease Chinese Center for Endemic Disease ControlHarbin Medical UniversityHarbin 150081China Affiliated Hospital of Jilin Medical College Jilin 132013China Hangzhou Center for Disease Control and Prevention Hangzhou 310021China Sanya Institute of Technology Sanya 572022 China Inner Mongolia Autonomous Region Mental Health Center Hohhot010010China

Objective:Keshan disease(KD)is a mitochondrial *** present study explored the roles of peroxisome proliferator-activated receptor(PPAR)-y coactivator-la(PGC-la),the key regulator of mitochondrial structure and function,and its coactivators in myocardial injury in chronic ***,the usefulness of these molecules in the diagnosis of chronic KD was assessed.

关键词： Keshan disease peroxisome proliferator-activated receptor-y coactivator-la myocardial injury lactate dehydrogenase

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 236-244页

作者： Hital Shah Tejal Gandhi Gujarat Technological University AhmedabadGujarat 382424India Department of Pharmacology Anand Pharmacy CollegeAnandGujarat 388001India

Objective:To investigate the cardioprotective potential of betulin in isoproterenol(ISO)-induced myocardial injury in ***:Wistar rats were divided into five groups(n=10):normal,ISO,nebivolol 5 mg/kg,and betulin(20&40 mg/kg).Nebivolol and betulin were administered orally for 29 ***(85 mg/kg)was administered subcutaneously on day 27 and day 28 to induce myocardial *** day 29,blood was collected for determination of cardiac markers,and hemodynamic parameters were *** levels of oxidative stress markers and the gene expressions of apoptotic markers and inflammatory mediators were ***,2,3,5-triphenyltetrazolium chloride staining and histopathological analysis were also ***:Betulin reduced the size of myocardial infarction,decreased elevated levels of cardiac enzymes,and maintained hemodynamic *** also inhibited ISO-induced upregulation of Bax,caspase-3,NF-κB,and IL-6,enhanced endogenous antioxidant enzymes,and reduced lipid ***,pretreatment with betulin alleviated myocardial ischemic damage,as reflected by reduced myonecrosis,edema,and inflammatory ***:Betulin exhibits strong cardioprotective activity against ISO-induced myocardial injury by anti-inflammatory,anti-apoptotic,and antioxidant activities.

关键词： NF-κB Isoproterenol Betulin myocardial injury Oxidative stress Inflammation Apoptosis

L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenol-induced cardiac hypertrophy

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Asian Pacific Journal of Tropical Biomedicine 2023年第1期13卷 17-25页

作者： Anitha Nagarajan Victor Arokia Doss Department of Biochemistry PSG College of Arts and ScienceCoimbatore-641014Tamil NaduIndia

Objective:To explore the therapeutic efficacy of L-carvone from Mentha spicata *** extracts against isoproterenol-induced cardiac hypertrophy in ***:Isoproterenol(5 mg/kg)was injected intraperitoneally into rats for one month to induce cardiac hypertrophy.L-carvone(25 and 100 mg/kg)was administered orally to treat cardiac *** cardioprotective activity of L-carvone was evaluated by electrocardiogram,histopathological analysis as well as determination of biochemical parameters and enzymatic ***:L-carvone from Mentha spicata *** 25 and 100 mg/kg ameliorated isoproterenol-induced cardiac hypertrophy,as evidenced by reduced QRS interval on electrocardiogram,and decreased heart weight and heart *** addition,both doses of L-carvone markedly lowered the levels of glucose,total protein,low-density lipoprotein cholesterol,aspartate transaminase,alanine transaminase,lactate dehydrogenase,creatine kinase MB,troponin-Ⅰ,N-terminal pro-B type natriuretic peptide and triglycerides while increasing high-density lipoprotein cholesterol and lipase level(P<0.05).Moreover,L-carvone alleviated contraction band necrosis,and reorganized the myofibrils with normal striations and myocytes as well as normal nuclei in cardiac histoarchitecture of rats with isoproterenol-induced cardiac ***:L-carvone from Mentha spicata *** extract can restore abnormal cardiac function and may be further explored as a therapeutic agent against the deleterious effects of cardiac hypertrophy after further evaluation.

关键词： Cardiac hypertrophy L-carvone Dyslipidemia myocardial injury Isoproterenol Mentha spicata

Acute myocardial injury in patients with COVID-19:Possible mechanisms and clinical implications

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World Journal of Clinical Cases 2022年第3期10卷 762-776页

作者： Iulia Rusu Malina Turlacu Miruna Mihaela Micheu Department of Cardiology Clinical Emergency Hospital of BucharestBucharest 014461Romania

Severe acute respiratory syndrome coronavirus 2 infection affects not only the lungs,but also the cardiovascular system,having a major impact on patients’*** injury(MI)occurs in the context of coronavirus infectious disease 2019(COVID-19)and is associated with a higher risk of severe clinical outcome and ***-19-related MI can have various clinical manifestations,of which the main ones are myocarditis,stress cardiomyopathy,acute coronary syndrome,and pulmonary *** exact mechanisms of how MI occurs in these patients are not yet fully *** injury,through direct viral myocardial invasion,and indirect injury,through interaction with angiotensin I converting enzyme 2,increased inflammation,and thrombocyte and endothelial dysfunction,could be involved in acute MI in patients with COVID-19.A better understanding of these multiple potential mechanisms may help to develop new targeted therapeutic *** purpose of this review is to provide the current understanding of the potential mechanisms involved in MI induced by COVID-19 and to discuss the current progress in the therapeutic strategies.

关键词： myocardial injury Myocarditis Stress cardiomyopathy Acute coronary syndrome Pulmonary embolism Coronavirus infectious disease SARS-CoV-2