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Evaluation of berries of Phytolacca dodecandra for growth inhibition of Histoplasma capsulatum *** and treatment of cases of epizootic lymphangitis in Ethiopia

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Asian Pacific Journal of Tropical Biomedicine 2012年第7期2卷 505-510页

作者： Negesse Mekonnen Eyasu Makonnen Nigatu Aklilu Gobena Ameni Department of Pharmacology School of MedicineAddis Ababa University Aklilu Lemma Institute of Pathobiology Addis Ababa University Society for the Protection of Animals Abroad(SPANA) School of Veterinary MedicineAddis Ababa University

Objective:To evaluate the berries of Phytolacca dodecundra(***) for its effect on Histoplasma cupsulatum ***(HCF) and for the treatment of cases of epizootic lymphangitis(***:Samples were collected from un-ruptured nodules of cases of EL at Debre Zeit and Akaki(central Ethiopia).Mycologieal culture and isolation of HCF were performed at the Akliln Lemma Institute of *** screening was done for n-butanol extract of *** to delect alkaloids,saponins,phenolic compounds and *** minimum inhibitory concentrations(MICs) and minimum fungicidal concentrations(MFCs) ol aqueous and n-butanol extracts of *** against FICF were determined by agar dilution *** the in vivo trial.5%simple ointment was prepared from n-butanol extract and applied topically to 24(twelve early and twelve moderate) cases of ***:Phytochemical screening showed that n-butanol extract ol *** was positive lor *** and phenolic compounds but negative for *** MFCs of n-butanol and aqueous extracts of *** were(0.039%-0.078%) and(0.625%-1.250%),*** MFCs of n-butanol and aqueous extracts of *** were(0.078%t-0.156%)and(1.250%-2.500%),*** MIC and MFC of ketoconazole(positive control) was(1.200×10^(-5)%-2.500×10^(-5)%) and(5.000× 10^(-5)%-1.000×10^(-4)%),respectively while growth was observed on free medium(negative control).From the total of 24 treated cases of EL,14(58.3%) responded lo treatment;however,10(41.7%) did not respond to *** was no significant difference in the degree of response to treatment between early and moderate cases(χ~2=0.086:P=***:It can be concluded that n-butanol extract of *** demonstrates antifungal effects while the aqueous extract shows no antifungal activity.

关键词： Epizootic lymphangitis Phytolacca dodecandra Histoplasma capsulatum var.farciminosum Minimum inhibitory concentration Minimum fungicidal concentration Phytochemical screening Antifungal activity Agar dilution assay mycological culture In vivo trial Contagious disease Chronic disease Lymphangitis

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