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Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome

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World Journal of Stem Cells 2021年第8期13卷 1134-1150页

作者： María B Monzón-Nomdedeu Karl J Morten Elisa Oltra School of Biotechnology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Nuffield Department of Women's and Reproductive Health The Women CentreUniversity of OxfordOxford OX39DUUnited Kingdom Department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

BACKGROUND Fibromyalgia(FM)and myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific *** patient heterogeneity linked to patient subgroups and variation in disease severity,anomalies are found in the blood and plasma of these patients when compared with healthy control *** seeming specificity of these“plasma factors”,as recently reported by Ron Davis and his group at Stanford University,CA,United States,and observations by our group,have led to the proposal that induced pluripotent stem cells(iPSCs)may be used as metabolic sensors for FM and ME/CFS,a hypothesis that is the basis for this indepth *** To identify metabolic signatures in FM and/or ME/CFS supporting the existence of disease-associated plasma factors to be sensed by *** A PRISMA(Preferred Reported Items for Systematic Reviews and Meta-analysis)-based systematic review of the literature was used to select original studies evaluating the metabolite profiles of FM and ME/CFS body *** MeSH terms“metabolomic”or“metabolites”in combination with FM and ME/CFS disease terms were screened against the PubMed *** original studies applying omics technologies,published in English,were *** data obtained were tabulated according to the disease and type of body fluid *** across studies were searched and P-values reported by the original studies were gathered to document significant differences found in the disease *** Eighteen previous studies show that some metabolites are commonly altered in ME/CFS and FM body *** vitro cell-based assays have the potential to be developed as screening platforms,providing evidence for the existence of factors in patient body fluids capable of altering morphology,differentiation state and/or growth ***,they can be further develo

关键词： myalgic encephalomyelitis/chronic fatigue syndrome Fibromyalgia Induced pluripotent stem cells Plasma factor Conditioned medium Sensor system

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Alcohol intolerance and myalgic encephalomyelitis/chronic fatigue

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World Journal of Neurology 2023年第3期9卷 17-27页

作者： Jessica Maciuch Leonard A Jason Center for Community Research DePaul UniversityChicagoIL 60614United States

BACKGROUND The literature is mixed about the occurrence of alcohol intolerance among patients with myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS).Surveys that asked respondents with ME/CFS whether they experienced alcohol intolerance within a recent time frame might produce inaccurate results because respondents may indicate that the symptom was not present if they avoid alcohol due to alcohol *** To overcome this methodologic problem,participants in the current study were asked whether they have avoided alcohol in the past 6 mo,and if they had,how severe their alcohol intolerance would be if they were to drink *** The instrument used was a validated scale called the DePaul symptom *** t-tests were performed among the alcohol intolerant or not alcohol intolerant *** alcohol intolerant group had 208 participants,and the not alcohol intolerant group had 96 *** Using specially designed questions to properly identify those with alcohol intolerance,those who experienced alcohol intolerance vs those who did not experience alcohol intolerance experienced more frequent/severe symptoms and *** addition,using a multiple regression analysis,the orthostatic intolerance symptom domain was related to alcohol *** The findings from the current study indicated that those with ME/CFS are more likely to experience alcohol *** addition,those with this symptom have more overall symptoms than those without alcohol intolerance.

关键词： myalgic encephalomyelitis/chronic fatigue syndrome Alcohol intolerance Orthostatic intolerance DePaul symptom questionnaire Symptom burden Methodology

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