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XPD Lys751Gln polymorphism and esophageal cancer risk: A meta-analysis involving 2288 cases and 4096 controls

World Journal of Gastroenterology 2011年第18期17卷 2343-2348页

作者： Ling Yuan Dan Cui Er-Jiang Zhao Chen-Zhi Jia Li-Dong Wang Wei-Quan Lu Department of Gastroenterology The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 HenanProvince China Department of Radiotherapy Henan Tumor Hospital and Institute Zhengzhou 450003 Henan Province China Department of Epidemiology HenanTumor Institute Zhengzhou 450003 Henan Province China Department of Epidemiology andBiostatistics College of Public Health Zhengzhou UniversityZhengzhou 450001 Henan Province China Department of Occupational and EnvironmentalHealth Sciences College of Public Health Zhengzhou Univer-sity Zhengzhou 450001 Henan Province China Henan Key Laboratory for Esophageal CancerResearch The First Affiliated Hospital College of Basic Medi-cine Zhengzhou University Zhengzhou 450052 Henan ProvinceChina

AIM: To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk. METHODS: We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 casecontrol studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the ***: The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity). CONCLUSION: Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.

关键词： Xeroderma pigmentosum group D Polymorphism Esophageal cancer mwta-analysis

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