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“细胞活动生命活力”——中国细胞生物学学会全体会员代...

作者： Juan Su~a,Pu You~a,Wen-Lin Li~a,Xin-Rong Tao~a,Hai-Ying Zhu~a,Yu-Cheng Yao~(a,b),Hong-Yu Yu~c,Qing-Wang Han~a,Bing Yu~a, Fang-Xia Liu~a,Jun Xu~d,Joseph T.Y.Lau~e,and Yi-Ping Hu~a a.Department of Cell Biology,Second Military Medical University,Xiangyin Rd.800,Shanghai 200433,P.R.China b.Division of Cardiology,University of California,Los Angeles,CA 90095,United States c.Department of Pathology,Changzheng hospital,Fcngyang Rd.415,Shanghai 200003,P.R.China d Department of Pathology,No.105 Hospital of PLA,Hefei 230031,P.R.China c.Department of Molecular and Cellular Biology,Roswell Park Cancer Institute,Buffalo,New York,NY 10021,United States

During early stage of embryonic development,the liver bud,arising from the foregut endoderm, is the beginning for the formation of future liver three-dimensional *** the gene expression profiles associated with this developmental stage have been well explored,the detailed cellular events are not as ***-mesenchymal transition(EMT) was thought to be essential for cell migration in the early vertebrate embryo but seldom demonstrated in human liver *** this study,we tried to identify the cell populations with both stem cell and EMT features in the human liver *** in situ studies show that the phenotype of EMT occurs at initiation of human liver development,accompanied by up-regulation of EMT associated genes.A human liver bud derived stem cell line(hLBSC) was established, which expressed not only genes specific to both mesenchymal cells and hepatic cells,but also Octamer-binding protein 4(OCT4) and *** in appropriate media,hLBSC differentiated into hepatocytes,adipocytes,osteoblast-like cells and neuron-like cells in *** transplanted into severe combined immunodeficiency mice pre-treated by carbon tetrachloride,hLBSC engrafted into the liver parenchyma and *** data suggest that mere are cell populations with stem cell and EMT-like properties in the human liver bud,which may play an important role in the beginning of the spatial structure construction of the liver.

关键词： epithelial-mesenchymal transition liver bud liver development multipotent stem cells fetal liver

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Applicability of tooth derived stem cells in neural regeneration

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Neural Regeneration Research 2016年第11期11卷 1704-1707页

作者： Ludovica Parisi Edoardo Manfredi Centro Universitario di Odontoiatria University of Parma Parma Italy Dip. Scienze Biomediche Biotecnologiche e Traslazionali University of Parma Parma Italy

Within the nervous system, regeneration is limited, and this is due to the small amount of neural stem cells, the inhibitory origin of the stem cell niche and often to the development of a scar which constitutes a mechanical barrier for the regeneration. Regarding these aspects, many efforts have been done in the re- search of a cell component that combined with scaffolds and growth factors could be suitable for nervous regeneration in regenerative medicine approaches. Autologous mesenchymal stem cells represent nowa- days the ideal candidate for this aim, thank to their multipotency and to their amount inside adult tissues. However, issues in their harvesting, through the use of invasive techniques, and problems involved in their ageing, require the research of new autologous sources. To this purpose, the recent discovery of a stem cells component in teeth, and which derive from neural crest cells, has came to the light the possibility of using dental stem cells in nervous system regeneration. In this work, in order to give guidelines on the use of dental stem cells for neural regeneration, we briefly introduce the concepts of regeneration and regenerative medicine, we then focus the attention on odontogenesis, which involves the formation and the presence of a stem component in different parts of teeth, and finally we describe some experimental approaches which are exploiting dental stem cells for neural studies.

关键词： multipotent stem cells odontogenesis regeneration brain spinal cord teeth

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Allogenic banking of dental pulp stem cells for innovative therapeutics

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World Journal of stem cells 2015年第7期7卷 1010-1021页

作者： Pierre-Yves Collart-Dutilleul Franck Chaubron John De Vos Frederic J Cuisinier Bio Nano Laboratory EA 4203 Montpellier 1 University Institut Clinident Bio Pharma Biopole Clermont-Limagne INSERM U1040 Genetic Instability of Human Pluripotent Stem Cells CHRU Montpellier Hospital Saint-EloiInstitut de Recherche en Biothérapie

Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat.

关键词： Adult stem cells multipotent stem cells Cell-based therapy Cell tissue bank

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