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Diverse coagulopathies in a rabbit model with different abdominal injuries

World Journal of Emergency Medicine 2017年第2期8卷 141-147页

作者： Ruo Wu Luo-gen Peng Hui-min Zhao Department of Emergency Medicine Haikou People's Hospital Affi liated to Central South University Department of Emergency Medicine the First Affi liated Hospital of Guangxi Medical University

BACKGROUND: Although coagulopathy can be very common in severe traumatic shock patients, the exact incidence and mechanism remain unclear. In this study, a traumatic shock rabbit model with special abdomen injuries was developed and evaluated by examining indicators of clotting and fi ***: Forty New Zealand white rabbits were randomly divided into four groups: group 1(sham), group 2(hemorrhage), group 3(hemorrhage-liver injury), and group 4(hemorrhage-liver injury/intestinal injury-peritonitis). Coagulation was detected by thromboelastography before trauma(T0), at 1 hour(T1) and 4 hours(T2) after ***: Rabbits that suffered from hemorrhage alone did not differ in coagulation capacity compared with the sham group. The clot initiations(R times) of group 3 at T1 and T2 were both shorter than those of groups 1, 2, and 4(Ptraumatic shock show diverse coagulopathy in the early phase. Isolated hemorrhagic shock shows no obvious effect on coagulation. In contrast, blunt hepatic injury with hemorrhage shows hypercoagulability, whereas blunt hepatic injury with hemorrhage coupled with peritonitis caused by a ruptured intestine shows a tendency toward hypocoagulability.

关键词： Hemorrhagic shock multiple trauma model Inflammation Coagulopathy Thromboelastography

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