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Erectile dysfunction: on the efficacy of a phosphodiesterase inhibitor in patients with multiple risk factors

Asian Journal of Andrology 1999年第4期1卷 211-214页

作者： Harvey A.Rosenstock Samuel D.Axelrad University of Texas Medical School Houston Texas USABaylor College of Medicine Houston Texas USA

1 Introduction With the 1998 introduction of sildenafil (Viagra), the first available oral phosphodiesterase inhibitor, there

关键词： sildenafil impotence phosphodiesterase inhibitors multiple risk factors

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multiple risk Factor Clustering and risk of Hypertension in the Mongolian Ethnic Population of China

引用

Biomedical and Environmental Sciences 2007年第5期20卷 381-385页

作者： CHANG-QING YING SONG-BIN FU QUN XU WEI-JUN TONG MING-WU FANG ZHENG-LAI WU CHANG-CHUN OIU YONG-HONG ZHANG Department of Epidemiology School of Public Health Harbin Medical University Harbin 150081 Heilongjiang China Laboratory of Medical Genetics Harbin Medical University Harbin 150081 Heilongjiang China National Laboratory of Medical Molecular Biology School of Basic Medicine Peking Union Medical College Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 China Department of Epidemiology School of Radiology Medicine and Public Health Suzhou University Suzhou 215123 Jiangsu China Department of Epidemiology School of Basic Medicine Peking Union Medical College Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 China

Objective To evaluate whether the clustering of risk factors, both environmental and genetic, increases the risk of essential hypertension （EH） and the accumulation of risk factors influences the blood pressure level in normotensives. Methods On the basis of a prevalence survey, 501 subjects of Mongolian ethnicity （243 hypertensives and 258 normotensives） who were not related to each other were selected to conduct a case-control study. All subjects were interviewed with questionnaires and their blood specimens were collected. Renin gene insertion/deletion （I/D） polymorphism, a new genetic marker, was genotyped with PCR and polyacrylamide gel electrophoresis. Results Overweight, alcohol consumption, and renin gene I/D polymorphism were significant risk factors of EH （P〈0.05）. The odds ratios （OR） for the number of risk factors were 2.39 （95%CI： 0.98-6.74） for one risk factor, 5.03 （95%CI： 2.06-14.18） for two, and 6.09 （95%CI： 1.85-22.38） for three respectively after adjusting for age and sex. In normotensives, age- and sex-adjusted mean blood pressures increased with more accumulation of risk factors. However, there were no significant differences among the different blood pressure levels according to the number of risk factors （P〉0.05）. Conclusion Overweight, alcohol consumption, and renin gene I/D polymorphism are risk factors of EH in the Mongolian ethnic population of China. The accumulation of the risk factors causes a sharp increase of the risk of EH.

关键词： Essential hypertension multiple risk factors Overweight Alcohol consumption Renin gene polymorphism

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