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Mortality from chronic liver disease:Recent trends and impact of the COVID-19 pandemic

World Journal of Gastroenterology 2023年第26期29卷 4166-4173页

作者： Ugo Fedeli Claudio Barbiellini Amidei Veronica Casotto Enrico Grande Mario Saia Alberto Zanetto Francesco Paolo Russo Epidemiological Department Azienda ZeroVeneto RegionPadova 35132Italy Integrated System for Health Social Assistance and WelfareNational Institute of StatisticsRome 00184Italy Clinical Governance Azienda ZeroVeneto RegionPadova 35132Italy Department of Surgery Oncology and Gastroenterology University of PaduaPadova 35128Italy Gastroenterology and Multivisceral Transplant Unit Azienda Ospedale-Universitàdi PadovaPadova 25128Italy

Prepandemic time trends in mortality from chronic liver disease(CLD)differed according to specific cause of death(decreasing for liver cirrhosis,stable or increasing for liver cancer),etiology(increasing for nonalcoholic fatty liver disease,generally decreasing for other etiologies),and world region(decreasing in areas with the highest burden of hepatitis B virus,increasing in Eastern Europe and other countries).The coronavirus disease 2019(COVID-19)pandemic affected mortality of patients with CLD both directly,with a higher risk for severe illness and death depending on age,stage and etiology of the disease,and indirectly,through social isolation and loss of support,harmful drinking,and difficulties in access to ***,only sparse data are available on variations in CLD as a cause of death during the *** the USA,in 2020-2021 a growth in mortality was registered for all liver diseases,more marked for alcoholic liver disease,especially among young people aged 25-44 years and in selected ethnic ***-19 related deaths accounted only for a minor part of the *** data from mortality registers of other countries are warranted,preferably adopting the so-called multiple cause-of-death approach,and extended to deaths attributed to viral hepatitis and liver cancer.

关键词： Mortality multiple causes of death COVID-19 Chronic liver disease Liver cirrhosis Liver cancer

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