检索结果-南通市图书馆

中国化学快报:英文版 2023年第9期34卷 193-198页

作者： Yingying Chen Qiang Zeng Bingyang Chu Zhigang Liu Xue Wei Mengran Chen Peipei Yang Minghai Tang Ting Niu Yongqian Jia Ying Qu Zhiyong Qian Department of Hematology and Institute of Hematology State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

multiple myeloma(MM)is the second most common hematological tumor characterized by the proliferation of monoclonal plasma ***(MEL)is commonly used in the treatment of MM and is especially essential for patients undergoing autologous stem cell transplantation(ASCT).Although many drugs for MM have been developed in recent years,chemotherapy followed by ASCT remains the optimal ***,the backbone of the conditioning regimen,brings severe toxicities at a high *** delivery systems enable drugs to be highly effective and have low *** this study,methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(MPEG-PDLLA)was chosen to encapsulate melphalan,and the characteristics,effectiveness,and safety of MEL/MPEG-PDLLA in vitro and in vivo were ***/MPEG-PDLLA showed slow release and was easily engulfed by MM cells despite a result of the antitumor assay comparable to that of free melphalan in *** in vivo results showed that MEL/MPEG-PDLLA could significantly alleviate tumor burden and prolong survival time without increasing the toxicity to vital *** addition,MEL/MPEG-PDLLA could significantly reduce the damage to the intestinal mucosa caused by *** conclusion,MEL/MPEG-PDLLA shows improved antitumor activity and has the potential to alleviate pains of MM patients undergoing ASCT.

关键词： Melphalan multiple myeloma MPEG-PDLLA Nanomicelle

Prognostic power of abnormal cytogenetics for multiple myeloma： a multicenter study in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第15期125卷 2663-2670页

作者： LAI Yue-yun HUANG Xiao-jun CAI Zhen CAO Xiang-shan CHEN Fang-ping CHEN Xie-qun CHEN Bao-an Peking University People's Hospital Peking University Institute of Hematology Beijing 100044 China Department of Hematology First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Hematology Third Affiliated Hospital of Soochow University Suzhou Jiangsu 213003 China Department of Hematology Xiangya Hospital of Central-South University Changsha Hunan 410008 China Department of Hematology Xijing Hospital Affiliated to the Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Hematology Zhongda Hospital Affiliated to Southeast University Nanjing Jiangsu 210009 China

Background Chromosomal abnormalities have been shown to play an important prognostic role in multiple myeloma （MM）. Interphase fluorescence in situ hybridization （i-FISH） has been much more effective to identify cytogenetic aberrations in MM than conventional cytogenetic technique （CC）. To clearly determine the cytogenetic features of Chinese MM patients and identify their prognostic implications, we designed a multicenter study based on i-FISH including 672 patients from 52 hospitals in China. Methods All 672 patients were systematically screened for the following genomic aberrations： del（13q）, IgH rearrangement, del（p53） and lq21 amplifications. Results The analysis showed that the chromosomal changes were detected in 22.1% patients by CC and in 82.3% patients by i-FISH. The most common abnormalities by CC were chromosome 1 aberrations （48.4%）, -13/13q- （37.6%）, hyperdiploidy （36.6%）, hypodiploidy （30.1%） and IgH rearrangements （23.7%）. The most frequent abnormalities by FISH was del（13q）, which was found in 60.4% patients, whereas IgH rearrangement, lq21 amplification and p53 deletions were detected in 57.6%, 49.0% and 34.7% cases, respectively. By statistical analysis, -13/13q- by CC was associated with low level of platelet （P=0.015）, hyperdiploidy was associated with low level of serum albumin （P=0.028）, and IgH rearrangement by FISH was associated with high level of 132 microglobulin （P=0.019）. Moreover, lq21 amplification and del（p53） by FISH conferred a high incidence of progressive disease （PD） after initial therapy. Metaphase detection of IgH rearrangements and chromosome 1 aberrations concurrently was associated with a short progression free survival （PFS）（P=-0.036）. No significant prognostic implications of other cytogenetic abnormalities were found associated with overall survival and PFS. Conclusions Chinese MM patients had similar cytogenetic abnormalities compared with the previous reported studies. However, the prognostic significance of FISH aber

关键词： cytogenetics multiple myeloma in situ hybridization, fluorescence

The role of circulating miRNAs in multiple myeloma

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2015年第12期58卷 1262-1269页

作者： ZHANG Ji XIAO XiaoJuan LIU Jing Department of Hematology The First Affiliated Hospital University of South China State Key Laboratory of Medical Genetics & School of Life Sciences Central South University

multiple myeloma(MM) is a common malignant hematological disease. Dysregulation of micro RNAs(mi RNAs) in MM cells and bone marrow microenviroment has important impacts on the initiation and progression of MM and drug resistance in MM cells. Recently, it was reported that MM patient serum and plasma contained sufficiently stable mi RNA signatures, and circulating mi RNAs could be identified and measured accurately from body fluid. Compared to conventional diagnostic parameters, the circulating mi RNA profile is appropriate for the diagnosis of MM and estimates patient progression and therapeutic outcome with higher specificity and sensitivity. In this review, we mainly focus on the potential of circulating mi RNAs as diagnostic, prognostic, and predictive biomarkers for MM and summarize the general strategies and methodologies for identification and measurement of circulating mi RNAs in various cancers. Furthermore, we discuss the correlation between circulating mi RNAs and the cytogenetic abnormalities and biochemical parameters assessed in multiple myeloma.

关键词： mi RNA multiple myeloma biomarker diagnosis

Prognostic factors and staging systems of multiple myeloma:a single centre study in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第19期120卷 1655-1658页

作者： TAO Zhong-fei FU Wei-jun YUAN Zhen-gang WANG Dong-xing CHEN Yu-bao HOU Jian Department of Haematology Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China

Background Previous studies found a range of prognostic factors but no consensus about the proper staging system for multiple myeloma has been achieved. This study explored the prognostic factors to find a staging system for multiple myeloma most suitable for Chinese patients. Methods Between February 1990 to August 2004, 206 patients （138 men and 68 women, mean aged （59±11） years） who were initially diagnosed as multiple myeloma in Changzheng Hospital （Shanghai, China） and had followup records were enrolled in this study. Potential prognostic factors were evaluated by univariate and multivariate analyses. Four staging systems were applied to compare their suitability for the patients. Results The median survival time of the patients was 33 months. The 1-, 3- and 5-year survival rates were 80.18%, 48.08% and 33.7% respectively. Factors identified as adversely affecting survival were older age, severe bone lesions, low haemoglobin, low platelet, low serum calcium, low serum albumin, high proportion of plasma cells in marrow, high serum creatinine, high serum β2 microglobulin and high C-reactive protein. Among these, only C-reactive protein, β2 microglobulin, albumin and age were the independent prognostic factors. There were statistically significant survival differences among the three groups in Durie Salmon staging system and Bataille staging system, but not in British Medical Research Council staging system or International Staging System. Conclusions High β2 microglobulin, high C-reactive protein, low albumin and old age are independent prognostic factors of multiple myeloma. Bataille staging system appears to be optimal for Chinese multiple myeloma patients.

关键词： multiple myeloma prognosis survival analysis clinical staging system

Development of multiple myeloma in a patient with chronic hepatitis C: A case report and review of the literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第14期12卷 2297-2300页

作者： Peter Laszlo Lakatos Sandor Fekete Margit Horanyi Simon Fischer Margit E Abonyi 1st Department of Medicine Semmelweis University Budapest Hungary Department of Hematology Szent Laszlo Hospital BudapestHungary Virus Laboratory OGYK BudapestHungary

An association between chronic hepatitis C virus （HCV） infection and essential mixed cryoglobulinaemia and non-Hodgkin lymphoma （NHL） has been suggested. However, a causative role of HCV in these conditions has not been established. The authors report a case of a 50 year-old woman with chronic hepatitis C （CHC） who has been fol- lowed up since 1998 due to a high viral load, genotype lb and moderately elevated liver function tests （LFTs）. Laboratory data and liver biopsy revealed moderate activity （grade： 5/18, stage： 1/6）. In April 1999, one-year interferon therapy was started. HCV-RNA became negative with normalization of LFTs. However, the patient relapsed during treatment. In September 2002, the patient was admitted for chronic back pain. ACT examination demonstrated degenerative changes. In March 2003, multiple myeloma was diagnosed （IgG-kappa, bone marrow biopsy： 50% plasma cell infiltration）. MRI revealed a compression fracture of the 5^th lumbar vertebral body and an abdominal mass in the right lower quadrant, infiltrating the canalis spinalis. Treatment with vincristine, adriamycin and dexamethasone （VAD） was started and bisphosphonate was administered regularly. In January 2004, after six cycles of VAD therapy, the multiple myeloma regressed. Thalidomide, as a second line treatment of refractory multiple myeloma （MM） was initiated, and followed by peginterferon-α2b and ribavirin against the HCV infection in June. In June 2005, LFTs returned to normal, while HCV-RNA was negative, demonstrating an end of treatment response. Although a pathogenic role of HCV infection in malignant lymphoproliferative disorders has not been established, NHL and possibly MM may develop in CHC patients, supporting a role of a complex follow-up in these patients.

关键词： HCV multiple myeloma Non-Hodgkin Lymphoma Extrahepatic manifestation

Clinical features of multiple myeloma invasion of the central nervous system in Chinese patients

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第11期123卷 1402-1406页

作者： QU Xiao-yan FU Wei-jun XI Hao ZHOU Fan WEI Wei HOU Jian Department of Hematology Changzheng Hospital Second Hospital Affiliated to the Second Military Medical University Shanghai 200003 China

Background Although neurologic manifestations often complicate the course of patients with multiple myeloma, direct central nervous system invasion is rare. This study explored the neurologic symptoms, signs, clinical features, therapy and prognosis of Chinese patients with central nervous system myeloma invasion. Methods The diagnosis, therapy and prognosis were analyzed retrospectively in 11 Chinese multiple myeloma patients with central nervous system infiltration from a total of 625 patients who have been treated at Changzheng Hospital （Shanghai, China） between January 1993 and May 2009. Survival curve was constructed with the use of Kaplan-Meier estimates. Results There were 11 patients with central nervous system involvement from 625 multiple myeloma patients. The occurrence rate was 1.8%. Ten of the 11 patients had other extramedullary diseases. Symptoms included cerebral symptoms, cranial nerve palsies, and spinal cord or spinal nerve roots symptoms. Cerebrospinal fluid was abnormal in 7 patients, usually exhibiting pleocytosis and elevated protein content, plus positive cytologic findings. Specific magnetic resonance imaging findings suggestive of central nervous system invasion were found in 9 patients. After a median follow-up of 19 months, 3 patients were alive. The median overall survival for all patients was 23 months, while the median overall survival for patients after central nervous system invasion was merely 6 months. Conclusions It is exceedingly rare for there to be central nervous system infiltration in multiple myeloma patients. When it occurs, the prognosis is extremely poor despite the use of aggressive local and systemic treatment including stem cell transplantation.

关键词： multiple myeloma central nervous system, clinical features therapy, prognosis

Coincidence of three solid tumors in a patient with multiple myeloma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第6期126卷 1186-1187页

作者： Muzaffer Keklik Serdar Sivgin Kemal Deniz Halit Karaca Olgun Kontas Suleyman Balkanli Celalettin Eroglu Ummuhan Abdulrezzak Gulfugan Kuzu Leylagul Kaynar Mustafa Cetin Ali Unal Bulent Eser Department of Hematology Faculty of Medicine Erciyes University Kavseri Turkey Department of Pathology Faculty of Medicine Erciyes University Kavseri Turkey Department of Medical Oncology Faculty of Medicine Erciyes University Kavseri Turkey Department of Radiation Oncology Faculty of Medicine Erciyes University Kavseri Turkey Department of Nuclear Medicine Faculty of Medicine Erciyes University Kavseri Turkey Department of Internal Medicine Faculty of Medicine Erciyes University Kavseri Turkey

multiple primary cancers （MPC） are specific .malignant tumors type, manifesting as more than one primary tumor diagnosed in the same patient, either simultaneously or sequentially. The diagnostic criteria include： the cancer must be clearly malignant as determined by histological evaluation; each cancer must be geographically separate and distinct;

关键词： colon cancer lung cancer multiple myeloma multiple primary cancer

Matrine and CYC116 Synergistically Inhibit Growth and Induce Apoptosis in multiple myeloma Cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2015年第8期21卷 635-639页

作者：周郁鸿冯尽意尤良顺孟海涛钱文斌 The First Affiliated Hospital of Zhejiang Chinese Medical University Institute of Hematology the First Affiliated HospitalCollege of MedicineZhejiang University

Objective： To investigate whether CYC116 can potentiate matdne-dependent growth inhibition and apoptosis in multiple myeloma （MM） cells. Methods： The dose response relationship of matrine to dexamethasone-resistant and dexamethasone-sensitive MM cells was first established. myeloma RPMI8226 cells were treated with matrine alone or combined with CYC116 for 24 h. Cell proliferation was measured using an M＇I-F assay and apoptosis induction was evaluated by flow cytometry. Activation ot the caspase pathway and expression of apoptosis regulator proteins were detected by Western blotting. Results： Matrine significantly induced growth arrest and apoptosis in both drug-resistant and drug-sensitive MM cells. Treatment with the combination of matrine and CYC116 had a stronger cytotoxic effect on MM cells than did single drug treatments. Enhanced apoptosis observed following the combined treatment of matrine and CYC116 was associated with higher levels of activation of caspase-9, caspase-3, and poly adenosine diphosphate ribose polymerase （PARP） and down-regulation of the anti-apoptotic proteins Bcl-2 and Mcl-1 and the signaling proteins p-Akt and nuclear factor K B （NF-κB）. Conclusions： CYC116 enhances the growth inhibitory and apoptotic effects of matrine on MM cells.

关键词： apoptosis aurora kinase CYC116 inhibitor matrine multiple myeloma

Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed multiple myeloma Patients： A Multicenter Study in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第2期130卷 130-134页

作者： Yu-Ping Zhong Yi-Zhuo Zhang Ai-Jun Liao Su-Xia Li Chen Tian Jin Lu Department of Hematology Beijing Chaoyang Hospital (West) Capital Medical University Beijing University Clinical Research Institute Beijing 100043 China Department of Hematology Tianjin Medical University Cancer Institute and Hospital Tianjin Cancer Hospital Tianjin 300000 China Department of Hematology Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Hematology The People's Liberation Army 301 Hospital Beijing 100853 China Department of Hematology The People's Liberation Army 304 Hospital Beijing 100048 China Department of Hematology Peking University People's Hospital and Peking University Institute of Hematology Beijing 100044 China

Background： Elderly multiple myeloma （MM） patients often tend to suffer a variety of diseases, so the treatment of choice is very difficult for the elderly myeloma patients. The overall survival （OS） time and side effects with elderly patients are unclear in China. The study tried to find out the role of geriatric assessment in the Chinese elderly MM. Methods： We retrospectively analyzed the data of 628 newly diagnosed patients from six hospitals from June 2011 to June 2013. A geriatric assessment had been performed to assess comorbidities, cognitive, and physical status for these patients. The primary endpoint was to evaluate different physical states of elderly patients with OS time and treatment-related side effects. Results： An additive scoring system （range： 0-5）, based on age, Katz＇s Activity of Daily Living （ADL） and Lawton＇s Instrumental Activity of Daily Living （IADL）〈5 and Charlson Comorbidity Index （CC1） was developed to identify three groups： fit （score = 0）; intermediate-fitness （score = 1 ）; and fi＇ail （score ≥2）. The 3-year OS was 63% in fit patients, 63% in intermediate-fimess patients, and 49% in frail patients ≥3 hematologic adverse events （AEs） were documented in 45 （35.4%） fit, 34 （34%） intermediate-fitness, and 121 （30.2%） frail patients. The risk of a grade ≥3 hematologic AEs was not significantly increase in intermediate-fitness （hazard ratios [HR]： 0.99, 95% confidence interval [CI]： 0.54 1.47, P = 1.000） and in frail patients （tfR： 1.16, 95% CI： 0.70-1.93, P- 0.558） compared with fit ones. Conclusions： MM occurs earlier in life and being advanced when the diagnosis is made in the mainland of China. The overall survival in fi＇ailty with International Staging System （ISS） ll/lll was the worst in all patients.

关键词： Geriatric Assessment Multicenter Study multiple myeloma

An interesting cause of esophageal ulcer etiology: multiple myeloma of IgG kappa subtype

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第14期12卷 2305-2307页

作者： Yavuz Pehlivan Alper Sevinc Ibrahim Sari Murat T Gulsen Mehmet Buyukberber Mehmet E Kalender Celalettin Camci Gaziantep University School of Medicine Departments of Internal MedicineMedical OncologyPathologyand GastroenterologySahinbey Medical CenterGaziantepTR-27310Turkey

multiple myeloma is a neoplasm of mature and immature plasma cells. A 50-year-old woman with lumbago, dysphagia, and left arm pain was presented. Upper endoscopical examination was performed. There was an exudate-covered ulcer in the distal esophagus, located at 30-32 cm from the incisors, covering the whole mucosa. Histopathological examination of the specimens obtained from the lesion showed the involvement of plasma cells consistent with multiple myeloma of IgG kappa subtype. Esophageal involvement of multiple myeloma should be kept in mind in patients presenting with dysphagia.

关键词： multiple myeloma Esophageal ulcer Dysphagia Endoscopy