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Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

Nano-Micro Letters 2020年第8期12卷 116-129页

作者： Xuanfang Zhou Zhouqi Meng Jialin She Yaojia Zhang Xuan Yi Hailin Zhou Jing Zhong Ziliang Dong Xiao Han Muchao Chen Qin Fan Kai Yang Chao Wang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123JiangsuPeople’s Republic of China State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123JiangsuPeople’s Republic of China

Radiotherapy(RT)is a widely used way for cancer ***,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so *** oxide(NO)is known a very effective radiosensitizer of hypoxic ***,NO cannot circulate in body with high ***,an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during ***-Butyl nitrite,which is an efficient NO source,is coupled to Ag2S quantum dots(QDs).NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal *** addition,Ag is also a type of heavy metal that can benefit the RT *** demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor ***,immunosuppressive tumor microenvironment is improved by our NO delivery system,significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery *** results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.

关键词： NO delivery Radio sensitivity multifunctional agent Radioimmunotherapy Drug delivery

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