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multidimensionally Nano‑topologized Polycaprolactone Fibrous Membrane Anchored with Bimetallic Peroxide Nanodots for Microenvironment‑Switched Treatment on Infected Diabetic Wounds

引用

Advanced Fiber Materials 2024年第6期6卷 1777-1797页

作者： Lin Qi Yong Huang Zheng Liu Jiangshan Liu Jing Wang Huilun Xu Hao Yang Limin Liu Ganjun Feng Shuyu Zhang Yubao Li Li Zhang Analytical and Testing Center Sichuan UniversityChengdu 610065China Department of Orthopedic Surgery and Orthopedic Research Institute&West China Hospital Sichuan UniversityChengdu 610065China West China School of Basic Medical Science and Forensic Medicine Sichuan UniversityChengdu 610065China

Delayed healing of diabetic wounds poses a major challenge to human health due to severe vascular dysfunction,sustained inflammation,and vulnerability to microbial ***,we constructed multidimensionally nano-topologized elec-trospun polycaprolactone(PCL)fibrous membranes with shish-kebab nanoarrays on each fiber through self-induced crys-tallization,on which the CuO2-MgO2 bimetallic peroxide nanodots(BPNs)were anchored by polydopamine(PDA)as the bridging *** activated by the acidic microenvironment(typically infected diabetic wound),BPNs on fibers reacted immediately to release Cu2+and Mg2+ions together with hydrogen peroxide(H2O2)molecules,which were then transferred into·OH radicals through Fenton-type reactions catalyzed by Cu2+for instant bacteria *** the same time,the released Cu2+and Mg2+ions were retained to improve the angiogenesis and suppress the inflammation infiltration,thus remodeling the wound ***,the one-dimensional(1D)-constructed nano shish-kebabs and PDA coating on fibers provided additional topological activation for cell adhesion and directed migration along the aligned fiber *** the meticulous design,the resultant membranes markedly accelerated the infected wound healing in the diabetic rat *** study pioneers a unique design to develop a nanocomposite fibrous membrane that combines multidimensional topologies with chemodynamic therapy(CDT),for efficiently combating infected diabetic wounds.

关键词： Electrospinning Polycaprolactone multidimensional topology Metal peroxides Diabetic wound

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