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multi-resistant bacteria in spontaneous bacterial peritonitis: A new step in management?

World Journal of Gastroenterology 2014年第39期20卷 14079-14086页

作者： Angelo Alves de Mattos Ane Micheli Costabeber Livia Caprara Lion?o Cristiane Valle Tovo Department of Gastroenterology Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre 90430-080 Brasil

Spontaneous bacterial peritonitis(SBP) is the most typical infection observed in cirrhosis patients. SBP is responsible for an in-hospital mortality rate of approximately 32%. Recently, pattern changes in the bacterial flora of cirrhosis patients have been observed, and an increase in the prevalence of infections caused by multi-resistant bacteria has been noted. The wide-scale use of quinolones in the prophylaxis of SBP has promoted flora modifications and resulted in the development of bacterial resistance. The efficacy of traditionally recommended therapy has been low in nosocomial infections(up to 40%), and multi-resistance has been observed in up to 22% of isolated germs in nosocomial SBP. For this reason, the use of a broad empirical spectrum antibiotic has been suggested in these situations. The distinction between community-acquired infectious episodes, healthcare-associated infections, or nosocomial infections, and the identification of risk factors for multi-resistant germs can aid in the decision-making process regarding the empirical choice of antibiotic therapy. Broad-spectrum antimicrobial agents, such as carbapenems with or without glycopeptides or piperacillin-tazobactam, should be considered for the initial treatment not only of nosocomial infections but also of healthcare-associated infections when the risk factors or severity signs for multi-resistant bacteria are apparent. The use of cephalosporins should be restricted to community-acquired infections.

关键词： Spontaneous peritonitis multi-resistant bacteria Cirrhosis Infection Ascites

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Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction

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Journal of Materials Science & Technology 2021年第9期68卷 160-171页

作者： Mingjun Li Christoph Schlaich Jianguang Zhang Ievgen S.Donskyi Karin Schwibbert Frank Schreiber Yi Xi Jorg Radnik Tanja Schwerdtle Rainer Haag Center for Health Science and Engineering Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologySchool of Materials Science and EngineeringHebei University of TechnologyTianjin 300130China Institut fur Chemie und Biochemie Freie Universitat BerlinBerlin 14195Germany Division Biodeterioration and Reference Organisms Federal Institute for Materials Research and Testing(BAM)Berlin 12205Germany Division of Surface Analysis and Interfacial Chemistry Federal Institute for Materials Research and Testing(BAM)Berlin 12205Germany Institute of Nutritional Science Department of Food ChemistryUniversity of PotsdamNuthetal D-14558Germany

bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles(Cu NPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol(MI-h PG) coating via a simple dip-coating *** hyperbranched polyglycerol with 10 % catechol groups’ modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone(PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated Cu NPs-incorporated PCL membrane [PCL-(MI-h PG)-Cu NPs]was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus(S. aureus), Escherichia coli(E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-h PG)-Cu NPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing Cu NPs.

关键词： Mussel-inspired coating CuNPs multi-resistant bacteria Antibacterial Antifouling Osteogenesis

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