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Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Frontiers of Environmental Science & Engineering 2022年第7期16卷 125-137页

作者： Shengqi Zhang Chengsong Ye Wenjun Zhao Lili An Xin Yu Lei Zhang Hongjie Sun Mingbao Feng College of the Environment&Ecology Xiamen UniversityXiamen361102China College of Geography and Environmental Science Zhejiang Normal UniversityJinhua321004China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361102China Core Facility of Biomedical Xiamen UniversityXiamen361102China

Accompanying an annual increase in cancer incidence,the global use of anticancer drugs has remarkably increased with their worldwide environmental prevalence and ecological *** this study,the oxidation of methotrexate(MTX),a typical anticancer drug with ubiquitous occurrence and multi-endpoint toxicity,by ferrate(VI)(Fe(VI))and permanganate(Mn(VII)))was investigated in ***(VI)exhibited a higher reactivity with MTX(93.34 M^(−1) s^(−1))than Mn(VII)(3.01 M^(−1) s^(−1)) at pH *** introduction of Cu(II)and Fe(III)at 1.0 mM improved the removal efficiency of 5.0μM MTX by 100.0μM Fe(VI)from 80%to 95%and 100%after 4 min,*** oxidized products(OPs)were identified during oxidative treatments,while OP-191 and OP-205 were characterized as specific products for Fe(VI)*** ketonization of the L-glutamic acid moiety and cleavage of the peptide bond of MTX were ***,a multi-endpoint toxicity evaluation indicated no genotoxicity,neurotoxicity,or endocrine-disrupting effects of MTX and its ***,serious developmental toxicity in zebrafish larvae was observed in the treated MTX *** on the acute and chronic aquatic toxicity prediction,OP-190,OP-192,OP-206,and OP-208 were deemed toxic or very toxic compared to harmful ***,the reduced biodegradability index from 0.15(MTX)to−0.5 to−0.2(OP-192,OP-206,and OP-468)indicated the formation of lower biodegradable ***,this study suggests that Fe(VI)and Mn(VII)oxidation are promising treatments for remediating anticancer drug-contaminated ***,the environmental risks associated with these treatments should be considered in the evaluation of water safety.

关键词： Anticancer drugs High-valent metal-oxo species Oxidation kinetics Reaction mechanisms multi-endpoint toxicity

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