检索结果-南通市图书馆

Detection of bursts in neuronal spike trains by the mean inter-spike interval method

Progress in Natural Science:Materials International 2009年第2期19卷 229-235页

作者： Lin Chena,b,Yong Deng c,Weihua Luo a,Zhen Wang a,Shaoqun Zenga,a Hubei Bioinformatics and Molecular Imaging Key Laboratory,Huazhong University of Science and Technology,Wuhan 430074,China b College of Mechanical Engineering,Guangxi University,Nanning,530004,China c College of Optoelectronic Science of Engineering,Huazhong University of Science and Technology,Wuhan 430074,China Hubei Bioinformatics and Molecular Imaging Key Laboratory Huazhong University of Science and Technology Wuhan 430074 China College of Mechanical Engineering Guangxi University Nanning 530004 China College of Optoelectronic Science of Engineering Huazhong University of Science and Technology Wuhan 430074 China

Bursts are electrical spikes firing with a high frequency,which are the most important property in synaptic plasticity and information processing in the central nervous system. However,bursts are difficult to identify because bursting activities or patterns vary with phys-iological conditions or external stimuli. In this paper,a simple method automatically to detect bursts in spike trains is described. This method auto-adaptively sets a parameter (mean inter-spike interval) according to intrinsic properties of the detected burst spike trains,without any arbitrary choices or any operator judgment. When the mean value of several successive inter-spike intervals is not larger than the parameter,a burst is identified. By this method,bursts can be automatically extracted from different bursting patterns of cultured neurons on multi-electrode arrays,as accurately as by visual inspection. Furthermore,significant changes of burst variables caused by electrical stimulus have been found in spontaneous activity of neuronal network. These suggest that the mean inter-spike interval method is robust for detecting changes in burst patterns and characteristics induced by environmental alterations.

关键词： Inter-spike interval Bursts Spike trains multi-electrode arrays

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

引用

Neuroscience Bulletin 2012年第4期28卷 409-422页

作者： Ming-Gang Liu Xue-Feng Chen Ting He Zhen Li Jun Chen Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders Tangdu HospitalThe FourthMilitary Medical UniversityXi'an 710038China Key Laboratory of Brain Stress and Behavior PLAXi'an 710038China Department of Brain and Cognitive Sciences College of Natural SciencesSeoul National UniversitySeoul 151-746South Korea

Simultaneous multisite recording using multi-electrode arrays（MEAs） in cultured and acutely-dissociated brain slices and other tissues is an emerging technique in the field of network *** the past 40 years,great efforts have been made by both scientists and commercial concerns,to advance this *** MEA technique has been widely applied to many regions of the brain,retina,heart and smooth muscle in various studies at the network *** present review starts from the development of MEA techniques and their uses in brain preparations,and then specifically concentrates on the use of MEA recordings in studies of synaptic plasticity at the network level in both the temporal and spatial *** the MEA technique helps bridge the gap between single-cell recordings and behavioral assays,its wide application will undoubtedly shed light on the mechanisms underlying brain functions and dysfunctions at the network level that remained largely unknown due to the technical difficulties before it matured.

关键词： multi-electrode arrays acute hippocampal slices spatial neural plasticity temporal neural plasticity network electrophysiology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lycium barbarum polysaccharides protect retinal visual pathway during photoreceptors degeneration

Lycium barbarum polysaccharides protect retinal visual pathw...

引用

中国神经科学学会第十二届全国学术会议

作者： Feng LIU Ying XU Jia ZHANG Zongqin XIANG Di XU Kwok-Fai SO Guangdong-Hongkong-Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Co-Innovation Center of Neuroregeneration Nantong University

Objective Retinitis pigmentosa（RP） is a hereditary retinal disease with progressive loss of rods followed by cones that lead to blindness. Lycium barbarum polysaccharides（LBPs） are the active components of wolfberry that protect retinal neurons in diseased animal models. Here we investigate whether LBP rescue the morphology and function of retina in rd1 mouse, a fast photoreceptor degenerated animal model, and how LBP affect the function of retinal ganglion cells（RGCs） during photoreceptors degeneration. Methods LBP or equal volume of vehicle was i.p. injected in rd1 mouse daily from postnatal day 4（P4） to P14, P20, P24 or P28 when photoreceptors totally degenerate. Immunostaining, electroretinogram（ERG）, visual behavior test and multi-electrode-array（MEA） recording were applied to check the structure and function of retina after the treatment. Results（1） Compare to the non-treated group, LBP treatment greatly promoted photoreceptor survival, enhanced ERG responses and improved the visual behavior in rd1 mice.（2） For the function of RGCs, LBP treatment significantly enhanced the percentage of light-responsive RGCs and increased the response, the responding speed and the signal-to-noise ratio of RGCs during photoreceptors degeneration till P24.（3） The spontaneous spiking, which usually increases during retinal degeneration, was overall inhibited by LBP;while the changes of the light-evoked responses and spontaneous spiking of various types RGCs in treated rd1 mice varied at different stages.（4） Intensity profile tested with a series of increasing flash intensities also showed improved light sensitivity in most RGCs after LBP treatment.（5） Furthermore, LBP treatment had better improvement on the OFF response than ON response. Conclusion LBP rescue the retinal morphology and function in rd1 mice, and delay the functional decay of retinal ganglion cells during photoreceptor degeneration, maybe with type dependent. Therefore, LBP treatment may help to elongate the effect

关键词： Retinal degenerative diseases Retinal Ganglion Cells multi-electrode arrays Lycium barbarum polysaccharides

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：