检索结果-南通市图书馆

Advanced Sensor and Energy Materials 2024年第3期3卷 2-10页

作者： Ping Li Chun-Feng Feng Peng-Fei Lyu Fei Liu Hui-Sheng Li Li-Qun Zhang Department of Maxillofacial and Ear Nose and Throat OncologyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Basic and Translational Medicine on Head&Neck CancerTianjinChina Department of Clinical Laboratory The Second Affiliated HospitalArmy Medical UniversityChongqingChina Department of Breast Oncology Department Tianjin Medical University Cancer Institute and HospitalTianjinChina

Herein,we proposed novel three-in-one DNA nanowheels with simultaneous chemo and gene therapy to treat tumor,especially to prevent simultaneous drug resistance,which could be disassembled via a cascaded hybridization reactions triggered by the highly expressed microRNA in cancer cells for smart and efficient cancer ***,with breast cancer as a model,microRNA 21 could trigger the self-disassembly of DNA nanowheel 1 via hybridization with a specially designed oligonucleotide(anti-microRNA 21)in DNA nanowheel 1,releasing another special oligonucleotide(Contact sequence)to trigger the self-disassembly of DNA nanowheel 2 with releasing of a special oligonucleotide(anti-Contact sequence)to trigger the self-disassembly of DNA nanowheel 1 cyclically,and thus the cascaded hybridization reactions with three-in-one anti-cancer functions could be generated based on three main therapeutic effects via releasing doxorubicin to inhibit macromolecular biosynthesis,antisense oligonucleotide of microRNA 21 to activate the apoptotic cell pathway and antisense oligonucleotide of MDR1 to prevent the drug resistance *** expected,the proposed method showed improved therapeutic efficacy on the cancer cells with about 80%apoptosis ratio,especially on the drug resistant cancer cells with about 75%apoptosis ratio,compared with that in the conventional anti-cancer systems of about 70%on cancer cells and below 40%on drug resistant cancer cells,*** importantly,this strategy opened the door for generation of complex functional DNA-based structures for target triggering drugs releasing system combining with chemo-and genetherapy to generate tumor regression and prevent drug resistance with an optimized therapeutic efficacy,providing a new avenue for efficient cancer treatment,especially drug resistant cancers.

关键词： DNA machine Drug resistance multi-combination strategy Self-disassembly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：