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A Biobank for Long-term and Sustainable research in the Field of Congenital Heart Disease in Germany

Genomics, Proteomics & Bioinformatics 2016年第4期14卷 181-190页

作者： Thomas Pickardt Eva Niggemeyer Ulrike M.M.Bauer Hashim Abdul-Khaliq Competence Network for Congenital Heart Defects Investigators National Register for Congenital Heart Defects 13353 BerlinGermany Saarland University Medical center Department of Paediatrie Cardiology66421 HomburgGermany Competence Network for Congenital Heart Defects 13353 BerlinGermany

Congenital heart disease （CHD） is the most fi＇equent birth defect （0.8% 1% of all live births）. Due to the advance in prenatal and postnatal early diagnosis and treatment, more than 90% of these patients survive into adulthood today. However, several mid- and long-term morbidi- ties are dominating the follow-up of these patients. Due to the rarity and heterogeneity of the phenotypes of CHD, multicenter registry-based studies are required. The CHD-Biobank was established in 2009 with the aim to collect DNA from patients and their parents （trios） or fi＇om affected families, as well as cardiovascular tissues from patients undergoing corrective heart surgery for cardiovascular malformations. Clinical/phenotype data are matched to the International Paediatric and Congenital Cardiac Code （IPCCC） and the International Statistical Classification of Diseases and Related Health Problems 10th Revision （ICD-10）. The DNA collection currently comprises samples from approximately 4200 participants with a wide range of CHD phenotypes. The collection covers about 430 trios and 120 families with more than one affected member. The cardiac tissue collection comprises 1143 tissue samples [Yore 556 patients alter open heart surgery. The CHD-Biobank provides a comprehensive basis for research in the field of CHD with high standards of data privacy, IT management, and sample logistics.

关键词： Congenital heart defects multi-center research Biorepository Genetic research DNA

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A multi-center investigation of breast-conserving surgery based on data from the Chinese Society of Breast Surgery(CSBrS-005)

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Chinese Medical Journal 2020年第22期133卷 2660-2664页

作者： Li-Xiang Yu Peng Shi Xing-Song Tian Zhi-Gang Yu 无 Department of Breast Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Department of Thyroid and Breast Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250033China Chinese Society of Breast Surgery

Background:Although breast-conserving surgery is one of the standard treatments for breast cancer,few studies have assessed its recent implementation in *** aimed to clarify the current real-world status of breast-conserving surgery in ***:This cross-sectional survey relied on data collected by the Chinese Society of Breast Surgery(CSBrS)to examine patients who underwent this surgery between January 2018 and December *** survey was conducted using a uniform electronic questionnaire to collect information,including clinical and pathological data on these ***:Overall,4459 breast-conserving surgeries were performed in 34 member units of CSBrS,accounting for 14.6%of all breast cancer surgeries performed in these units during the study *** patients who underwent breast-conserving surgery with information on tumor size available,more than half(61.2%)of the tumors were smaller than 2 cm in diameter,and only 87(3.2%)tumors were larger than 4 cm in *** patients who underwent breast-conserving surgeries,457(10.2%)patients received neoadjuvant therapy before the *** patients with a reported margin width,34(2.0%)patients had a margin of≤2 mm,and 1530(88.2%)of them had a margin of>5 ***:This study demonstrated the rates of breast-conserving surgery in member units of the CSBrS,and introduced the characteristics and surgical margins of patients who underwent this *** information helps describe the real-world status of breast-conserving surgery in China.

关键词： Breast cancer Breast-conserving surgery multi-center research Real-world study

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