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Direct and Residual Microbicidal Efficacy of Various Antiseptics against multi-drug resistant bacteria

Advances in Infectious Diseases 2023年第4期13卷 596-608页

作者： Jose Ramon Martinez-Mendez Rafael Herruzo Angela Ojeda La Paz University Hospital Paseo de la Castellana Madrid Spain Autonomous University of Madrid Calle del Arzobispo Morcillo Madrid Spain

Background: Infections in ICU’s patients are known to often originate from the colonization of wounds by the patient’s endogenous microbiota, and to eventually lead to secondary sepsis. Aim: to compare in vitro the direct and residual effects after different exposure times of 4% chlorhexidine, and of 0.1% and 0.04% polyhexanide (in gel and solution forms), on ATCC-microorganisms, and too, on bacterial strains obtained from ICU patients. Methods: We used wild multi-drug resistant strains recently obtained from the wounds of patients hospitalized at ICU and reference strains from the American Type Culture Collection (ATCC). Chlorhexidine 4% was studied as a reference solution. The direct and residual effects of the 0.1% and 0.04% polyhexanide, in gel and solution forms, were analyzed using cotton germ carriers. To evaluate the direct effect, we exposed the strains to the antiseptic. To assess the residual effect, the germ-carriers were impregnated with antiseptic and were allowed to dry before we contaminated them. We inoculated the germ carriers in a culture medium with an inhibitor of antiseptic effect to count the number of surviving microorganisms. Findings: 0.1% Polyhexanide solution proved a direct and residual efficacy after 24 hours equivalent to 4% chlorhexidine. Is very important to highlight that this great efficacy did not change according to whether they were ATCC or multidrug-resistant strains. Conclusions: 0.1% polyhexanide demonstrated a great direct and residual efficacy (like 4% chlorhexidine), against multi-drug resistant strains isolated from ICU’s patients. Moreover, due to its few cytotoxicity against keratinocytes and fibroblasts can be an optimal antiseptic for burns, wounds or ulcers.

关键词： Antimicrobial Efficacy Antiseptic multi-drug resistant bacteria Tissue Toxicity Wounds

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Analysis of Clinical Symptoms Improvement in Treatment of Severe Pneumonia Caused by multi-drug resistant bacterial Infection by Bronchoscopy Alveolar Lavage

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Journal of Clinical and Nursing Research 2021年第4期5卷 180-184页

作者： Xiang Wang Zuozhou Xie Jinhong Zhao Yi Liu Kunming Second People's Hospital Kunming 650203Yunnan ProvinceChina

Objective:To explore the effects of bronchoscopy alveolar lavage in the treatment of severe pneumonia caused by multiple drug bacterial ***:A total of 84 patients with severe pneumonia infected by multi-drug resistant bacteria were randomly selected from Kunming Second People's Hospital,which is our hospital from January 2019 to December 2020 for this *** were divided into a reference group and a study group using a digital table method,with 42 cases in each *** reference group was given the routine treatment,the research group performed bronchoscopy alveolar lavage on this basis to observe the curative ***:Before treatment,there was no significant difference in serum factor indexes and blood gas analysis indexes between the two groups of patients,P>*** treatment,the time of fever,cough,moist rales disappearing and infection control time in the study group were shorter than those in the reference group,Pmulti-drug resistant bacterial infection,and the effects are significant.

关键词： Bronchoscopy alveolar lavage multi-drug resistant bacteria Severe pneumonia Clinical symptoms

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Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain

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Chinese Chemical Letters 2016年第2期27卷 235-240页

作者： Chen-Yu Ling Yun-Liang Tao Wen-Jing Chu Hui Wang Hai-Dong Wang Yu-She Yang State Key Laboratory of drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Petrochemical Engineering Changzhou University Department of Microbiology China Pharmaceutical University

A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of the derivatives exhibited potent antibacterial activity against drug resistant Gram-positive strains. Compounds 12 a, 12 d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781. As the metabolic stability of this series is not satisfactory, further modifications are going on to improve their pharmacokinetic profile.

关键词： multi-drug resistant bacteria Pleuromutilin 4H-Pyran-4-one Antibacterial activity

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Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection

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BMEMat(BioMedical Engineering Materials) 2024年第3期2卷 123-136页

作者： Lin Han Zhonghua Yuan Hui-Min Ren Weizhuo Song Ruonan Wu Jie Li Zhaoyan Guo Bingran Yu Shun Duan Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical TechnologyMinistry of Education)Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijingChina Beijing Research Institute of Chemical Industry SinopecBeijingChina

The escalating issue of lung infections induced by multi-drug resistant(MDR)bacteria is threatening human ***,the development of efficient drug delivery systems is essential to eliminate MDR bacterial lung infections ***,we designed inhalable drug-loaded nano-assemblies by the electrostatic interaction between negatively charged sodium alginate and a positively charged antibacterial polymer,quaternized polyethyleneimine(QPEI-C_(6)),as well as a kind of typical antibiotic for therapy of lung infection,azithromycin(AZT).By adjusting the feed ratios,we optimized the size of the nano-assembly to approximately 200 nm(STQ_(12)),which was beneficial for penetration through the mucus layer and *** the slightly acidic environment of the infected site,the nano-assembly could dissemble responsively and release AZT and QPEI-C_(6).Because of the combined bactericidal effect,STQ_(12)exhibited high bactericidal efficiency against MDR *** animal experiments,STQ_(12)showed notable efficacy against MDR bacterial lung *** transcriptomic results showed that the main effects of STQ_(12)against bacteria were through influencing the bacterial cell components and metabolic processes,and affecting their growth and *** work provides a promising strategy to treat MDR bacterium-induced lower respiratory tract infections.

关键词： antibacterial infection responsiveness multi-drug resistant bacteria nano-assembly polysaccharide

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Current concepts and future strategies in the antimicrobial therapy of emerging Gram-positive spontaneous bacterial peritonitis

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World Journal of Hepatology 2017年第30期9卷 1166-1175页

作者： Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace Department of Anesth-esiological Surgical and Emergency SciencesUniversity of Campania 'Luigi Vanvitelli' Department of Clinical Medicine and Surgery Section of Infectious DiseasesUniversity of Naples Federico Ⅱ Division of Infectious Diseases 'San Giuseppe Moscati' Hospital

Spontaneous bacterial peritonitis(SBP) is the most common infection in end-stage liver disease *** is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm^3 without an evident intra-abdominal surgically treatable *** mechanisms contribute to SBP occurrence,including translocation of gut bacteria and their products,reduced intestinal motility provoking bacterial overgrowth,alteration of the gut's barrier function and local immune ***,Gram-negative enteric bacteria have been the main causative agents of SBP,thereby guiding the empirical therapeutic ***,over the last decade,a worryingly increasing prevalence of Gram-positive and multi-drug resistant(MDR) SBP has been ***,the microbiological spectrum of SBP seems to have changed in Europe due to a high prevalence of Gram-positive bacteria(48%-62%).The overall proportion of MDR bacteria is up to 22%-73% of ***,empirical therapy based on thirdgeneration cephalosporins or amoxicillin/clavulanic acid,can no longer be considered the standard of care,as these drugs are associated with poor *** of this review is to describe,with an epidemiological focus,the evidence behind this rise in Gram-positive and MDR SBP from 2000 to present,and illustrate potential targeted therapeutic *** appropriate treatment protocol should include daptomycin plus ceftaroline and meropenem,with prompt stepdown to a narrower spectrum when cultures and sensitivity data are available in order to reduce both cost and potential antibiotic resistance development.

关键词： Spontaneous bacterial peritonitis multi-drug resistant bacteria End-stage liver disease Cirrhosis Critically ill patient

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Analysis of Influencing Factors and Predictive Models of multidrug-resistant bacterial Infection in Severe Patients

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Proceedings of Anticancer Research 2021年第1期5卷 1-5页

作者： Xianhui Wang Jilin Central Hospital Jilin City 132000Jilin ProvinceChina

Objective:To investigate the influencing factors of multi-drug resistant bacterial infections in patients with severe disease and establish a predictive ***:207 infected patients in our hospital from 2018 to May 2020 were selected for the study,of which 73 carried drug-resistant ***:The risk factor network of people infected with multidrug resistant bacteria is higher than that of people infected with non-multidrug resistant bacteria,and the interaction between risk factors of the former is ***:Antibiotics must be used appropriately after *** the elderly was abnormal in indicators such as fever and procalcitonin in the ward,they should be considered as high-risk groups of MDRO *** need special care and preventive measures.

关键词： Severe patients multi-drug resistant bacteria Infection Influencing factors

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