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Effect of ageing on colonic mucosal regeneration

World Journal of Gastroenterology 2011年第25期17卷 2981-2986页

作者： Ferenc Sipos Katalin Leiszter Zsolt Tulassay 2nd Department of Internal Medicine Semmelweis University Molecular Medicine Research Unit Hungarian Academy of Sciences

The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the *** the one hand,age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation,which results in epithelial *** the other hand,the altered migration and function of regenerative stem cells,the age-related methylation of mucosal healing-associated genes,together with the alterations of growth factor signaling with age,may be involved in delayed mucosal *** connections of these alterations to the process of ageing are not fully *** understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic ***,we aim to summarize the age-related microscopic and molecular changes of the human colon,as well as their role in altered mucosal healing.

关键词： Colon mucosal repair Ageing Colorectalcancer Telomere shortening DNA methylation

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Isolated lymphoid follicles in colon: Switch points between inflammation and colorectal cancer?

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World Journal of Gastroenterology 2011年第13期17卷 1666-1673页

作者： Ferenc Sipos Gyrgyi Müzes 2nd Department of Internal Medicine Semmelweis University

Gut-associated lymphoid tissue is supposed to play a central role in both the organization of colonic repair mechanisms and colorectal carcinogenesis. In inflammatory conditions, the number, diameter and density of isolated lymphoid follicles (ILFs) increases. They are not only involved in immune surveillance, but their presence is also indispensable in normal mucosal regeneration of the colon. In carcinogenesis, ILFs may play a dual role. On the one hand they may support tumor growth and the metastatic process by vascular endothelial growth factor receptor signaling and producing a specific cytokine and cellular milieu, but on the other hand their presence is sometimes associated with a better prognosis. The relation of ILFs to bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts or crypt formation, which are all involved in mucosal repair and carcinogenesis, has not been directly studied. Data about the putative organizer role of ILFs is scattered in scientific literature.

关键词： Isolated lymphoid follicle Colon mucosal repair Colorectal cancer Epithelial stem cell Myofibroblast Follicular dendritic cell Mesenchymal-epithelial transition Epithelial-mesenchymal transition

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