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Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model

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World Journal of Gastroenterology 2022年第18期28卷 1981-1995页

作者： Na Wu Yu-Qing Feng Na Lyu Di Wang Wei-Dong Yu Yong-Fei Hu Department of Central Laboratory&Institute of Clinical Molecular Biology Peking University People’s HospitalBeijing 100044China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

BACKGROUND Fusobacterium nucleatum(***)has long been known to cause opportunistic infections and has recently been implicated in colorectal cancer(CRC),which has attracted broad ***,the mechanism by which it is involved in CRC development is not fully *** To explore its potential causative role in CRC development,we evaluated the colon pathology,mucosa barrier,colon microbiota and host transcriptome profile after *** infection in an azoxymethane/dextran sulfate sodium salt(AOM/DSS)mouse *** Three groups of mice were compared to reveal the differences,i.e.,the control,AOM/DSS-induced CRC and AOM/DSS-FUSO infection *** Both the AOM/DSS and AOM/DSS-FUSO groups exhibited a significantly reduced body weight and increased tumor numbers than the control group,and AOM/DSS mice with *** infection showed the highest tumor formation ratio among the three ***,the colon pathology was the most serious in the AOM/DSS-FUSO *** found that the structure of the colon microbiota changed considerably after *** infection;striking differences in mucosal microbial population patterns were observed between the AOM/DSS-FUSO and AOM/DSS groups,and inflammation-inducing bacteria were enriched in the mucosal microbiota in the AOM/DSS-FUSO *** comparing intestinal transcriptomics data from AOM vs AOM/DSSFUSO mice,we showed that transcriptional activity was strongly affected by dysbiosis of the gut *** most microbiota-sensitive genes were oncogenes in the intestine,and the cyclic adenosine monophosphate signaling pathway,neuroactive ligand–receptor interaction,PPAR signaling pathway,retinol metabolism,mineral absorption and drug metabolism were highly enriched in the AOM/DSS-FUSO ***,we showed that microbial dysbiosis driven by *** infection enriched eight taxa belonging to Proteobacteria,which correlates with increased expression of oncogenic *** Our

关键词： Fusobacterium nucleatum mucosal microbiota Transcriptome Colorectal cancer Inflammation-inducing bacteria

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Alteration of ascending colon mucosal microbiota in patients after cholecystectomy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2436-2450页

作者： Miao-Yan Fan Qiao-Li Jiang Meng-Yan Cui Meng-Qi Zhao Jing-Jing Wang Ying-Ying Lu Department of Gastroenterology Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201803China Shanghai Key Laboratory of Pancreatic Diseases Institute of Translational MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

BACKGROUND Cholecystectomy is a successful treatment option for gallstones,although the inci-dence of colorectal cancer(CRC)has notably increased in post-cholecystectomy(PC)***,it remains uncertain whether the altered mucosal micro-biota in the ascending colon is *** total,30 PC patients and 28 healthy controls underwent colonoscopies to collect mucosal biopsy *** patients were divided based on their clinical ***,16S-rRNA gene sequencing was used to analyze the amplicon,alpha diversity,beta diversity,and composition of the bacterial ***-tionally,the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)database,sourced from the Kyoto Encyclopedia of Genes and Genomes,was used to predict the functional capabilities of the *** PC patients were comparable with healthy ***,PC patients older than 60 years had a distinct composition compared to those under 60 years *** richness was considerably higher at the phylum level in PC ***,Parabacteroides,and Bilophila were more abundant in the PC group than in the control ***,PC patients exhibited greater enrichment in metabolic pathways,specifically those related to lipopolysaccharide biosynthesis and vancomycin group antibiotic production,than *** This study indicated that the mucosal microbiota in PC patients was altered,perhaps offering new perspectives on the treatment possibilities for CRC and diarrhea following cholecystectomy.

关键词： Post-cholecystectomy Ascending colon mucosal microbiota Colorectal cancer Diarrhea

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Diet-induced reconstruction of mucosal microbiota associated with alteration of epithelium lectin expression and regulation in maintenance of rumen homeostasis

Diet-induced reconstruction of mucosal microbiota associated...

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中国生理学会内分泌代谢、比较生理与应激生理学术会议

作者： Hong Shen Zhihui Xu Zanming Shen Zhongyan Lu College of Life Science Nanjing Agricultural University Bioinformatics Center Nanjing Agricultural University Key Lab of Animal Physiology and Biochemistry College of Veterinary MedicineNanjing Agricultural University

Objective The mucosal microbiota in the gastrointestinal（GI） tract plays a pivotal role in local and systemic host *** are evolutionally conserved pattern-recognition receptors（PRPs） mediating the agglutination and immobilization of recognized *** lectins of epithelial cells（ECs） contribute to the recognition of mucosal microbes and the activation of tolerogenic cytokines in the gastrointestinal（GI） tract of animals is *** We applied an integrated method of RNA-seq and 16 S rRNA gene sequencing to investigate the alteration of epithelial lectin expression and regulation with a diet-induced reconstruction of mucosal microbiota in goat *** Our results showed that the diversity and richness of rumen mucosal microbiota were promoted by the low energy ***,in rumen epithelium,five lectin genes,namely sialic acid-binding Ig-like lectin 14（LOC102180073）,C-type lectin domain family 4,member E（CLEC4 E）,C-type lectin domain family 7,member A（CLEC7 A）,C-type lectin domain family 16,member A（CLEC16 A）,and lectin,mannose-binding 2（LMAN2） were indicated to promote the expressions of 8 cytokine genes,transforming growth factor beta 1（TGFB1）,and 4 enzyme genes involved in retinoic acid biosynthesis via 6 signaling *** analysis of combined data showed 8 microbial genera（ClostridiumV,Desulfobulbus,Eubacterium,Ochrobactrum,Propionibacterium,Pseudomonas,Slackia,Staphylococcus and Subdivision5eneraS） were highly related to the expression of functioned *** findings provide new insights into the interaction between the epithelium and mucosal microbiota in the maintenance of GI homeostasis.

关键词： mucosal microbiota epithelium lectin rumen homeostasis diet

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Mucosa-associated microbiota alterations in primary sclerosing cholangitis(PSC)before and after liver transplantation-who is calling the shots?

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 795-797页

作者： Münevver Demir Michael Sigal Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharitéUniversitätsmedizin BerlinBerlinGermany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular MedicineBerlinGermany

Primary sclerosing cholangitis(PSC)is an immune-related chronic cholangiopathy associated with high rates of progression to liver cirrhosis and the need for liver *** PSC is frequently associated with inflammatory bowel disease(IBD),several studies have investigated the role of the gut-liver axis in PSC and emerging evidence indicates that gut and bile microbiota are associated with the onset and progression of PSC[reviewed in(1)].

关键词： Primary sclerosing cholangitis(PSC) liver transplantation Klebsiella microbiota mucosal microbiota

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